哺乳动物早期胚胎滋养外胚层发育的研究进展

doi:10.11843/j.issn.0366-6964.2018.10.003

摘要/Abstract

摘要：

囊胚形成过程中，胚胎卵裂球分化为滋养外胚层和内细胞团细胞。囊胚孵出后，滋养外胚层又分化为极滋养层和壁滋养层。滋养外胚层的分化对哺乳动物早期胚胎发育至关重要。研究表明，影响滋养外胚层发育的关键基因主要为Tead 4、Cdx 2和Eomes，敲除或突变这些基因将导致滋养外胚层细胞分化错误，而滋养外胚层的完整性、渗透性和液体转运功能受损也将导致囊胚形成失败。本文主要综述了哺乳动物滋养外胚层的发育、滋养外胚层发育需要的关键基因、调控滋养外胚层完整性和功能相关的蛋白，以及这些蛋白与滋养外胚层发育关键基因之间可能存在的关系，为进一步研究哺乳动物早期胚胎滋养外胚层的调控机制提供参考。

Abstract:

During the blastocyst development, embryonic blastomeres were differentiated into trophectoderm and inner cell mass. After the blastocyst hatching, trophectoderm was differentiated into polar trophoblast and mural trophoblast.The differentiation of trophectoderm was very important for early embryonic development in mammals. Tead 4, Cdx 2 and Eomes are primary genes affecting trophectoderm development and knockout or mutation of these genes result in incorrect differentiation of trophectoderm. While the integrality, permeability and fluid transport function of trophectoderm were disfigured, which further led to the failure of blastocyst formation. We comprehensively discussed the development process of trophectoderm, pivotal genes for its formation, key proteins related to its integrality and function as well as underlying potential relationship between these key proteins and pivotal genes, which may provide information for further understanding the molecular mechanisms regulating embryonic trophectoderm development in mammals.

中图分类号:

S814

张艳艳, 彭辉, 肖天放. 哺乳动物早期胚胎滋养外胚层发育的研究进展[J]. 畜牧兽医学报, 2018, 49(10): 2080-2085.

ZHANG Yan-yan, PENG Hui, XIAO Tian-fang. Research Progress of Trophectoderm Development of Early Embryo in Mammals[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(10): 2080-2085.

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