干扰素-ε研究进展

doi:10.11843/j.issn.0366-6964.2021.011.004

Abstract

Abstract: Interferon-epsilon (IFN-ε) is a novel type I interferons (IFNs), which is also a type of cytokines secreted by varieties of cells. It is a glycoprotein, which can exert antiviral, immunoregulatory and anti-tumor biological activities. However, unlike other type I IFNs, IFN-ε is constitutively expressed by mucous epithelial cell and regulated by hormones without virus induction. IFN-ε plays an important role in mucosal immunity. At present, there are few reports on related studies. In this paper, we reviewed the research progress of IFN-ε origin of human and different animals, distribution in vivo, protection of reproductive system, regulation of nervous system and antiviral effect, to further understand and develop new IFNs reagent.

Key words: interferon-ε, cytokines, constitutive expression, antiviral activity

CLC Number:

S852.4

ZHANG Hailing, LIAN Shizhen, ZHANG Dongliang, BAI Xue, ZHANG Shasha, ZHANG Lei, LI Wei, LIU Fangyuan, WANG Han, HU Bo, LU Shiying. Research Progress of Interferon-ε[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(11): 3023-3029.

References 67

[1]	PARK A, IWASAKI A.Type I and type Ⅲ interferons-induction, signaling, evasion, and application to combat COVID-19[J].Cell Host Microbe, 2020, 27(6):870-878.
[2]	MOORE G E.Interferon[J].Surg Gynecol Obstet, 1981, 153(1):97-102.
[3]	CHELBI-ALIX M K, WIETZERBIN J.Interferon, a growing cytokine family:50 years of interferon research[J].Biochimie, 2007, 89(6-7):713-718.
[4]	MA X X, MA L N, CHANG Q Y, et al. Type I interferon induced and antagonized by foot-and-mouth disease virus[J].Front Microbiol, 2018, 9:1862.
[5]	DELHAYE S, PAUL S, BLAKQORI G, et al. Neurons produce type I interferon during viral encephalitis[J].Proc Natl Acad Sci U S A, 2006, 103(20):7835-7840.
[6]	SCHOGGINS J W, RICE C M.Interferon-stimulated genes and their antiviral effector functions[J].Curr Opin Virol, 2011, 1(6):519-525.
[7]	WANG B X, FISH E N.Global virus outbreaks:Interferons as 1st responders[J].Semin Immunol, 2019, 43:101300.
[8]	BORDEN E C.Interferons α and β in cancer:Therapeutic opportunities from new insights[J].Nat Rev Drug Discov, 2019, 18(3):219-234.
[9]	IVASHKIV L B, DONLIN L T.Regulation of type I interferon responses[J].Nat Rev Immunol, 2014, 14(1):36-49.
[10]	SCHNEIDER W M, CHEVILLOTTE M D, RICE C M.Interferon-stimulated genes:a complex web of host defenses[J].Annu Rev Immunol, 2014, 32:513-545.
[11]	GALABOV A S.Induction and characterization of tortoise interferon[J].Methods Enzymol, 1981, 78:196-208.
[12]	ZHANG H L, ZHAO J J, BAI X, et al. Cloning and expression of mink (Neovison vison) interferon-γ gene and development of an antiviral assay[J].Res Vet Sci, 2015, 101:93-98.
[13]	STOSIK M, TOKARZ-DEPTULA B, DEPTULA W.Type I interferons in ray-finned fish (Actinopterygii)[J].Fish Shellfish Immunol, 2021, 110:35-43.
[14]	SPROOTEN J, AGOSTINIS P, GARG A D.Type I interferons and dendritic cells in cancer immunotherapy[J].Int Rev Cell Mol Biol, 2019, 348:217-262.
[15]	ZHENG X D, XIE T L, LIN Y, et al. Immune response and mechanisms of IFN-γ in administration for keratomycosis[J].Ocul Immunol Inflamm, 2019, 27(6):958-967.
[16]	BURKE J D, YOUNG H A.IFN-γ:a cytokine at the right time, is in the right place[J].Semin Immunol, 2019, 43:101280.
[17]	KRISNAWATI D I, LIU Y C, LEE Y J, et al. Blockade effects of anti-interferon-(IFN-) γ autoantibodies on IFN-γ-regulated antimicrobial immunity[J].J Immunol Res, 2019, 2019:1629258.
[18]	CHINNASWAMY S, KOWALSKI M L.The genetic association of IFN-λs with human inflammatory disorders remains a conundrum[J].J Interferon Cytokine Res, 2019, 39(10):594-598.
[19]	LI L, XUE M, FU F, et al. IFN-lambda 3 mediates antiviral protection against porcine epidemic diarrhea virus by inducing a distinct antiviral transcript profile in porcine intestinal epithelia[J].Front Immunol, 2019, 10:2394.
[20]	YE L, SCHNEPF D, STAEHELI P.Interferon-λ orchestrates innate and adaptive mucosal immune responses[J].Nat Rev Immunol, 2019, 19(10):614-625.
[21]	AHN D, PRINCE A.Participation of the IL-10RB related cytokines, IL-22 and IFN-λ in defense of the airway mucosal barrier[J].Front Cell Infect Microbiol, 2020, 10:300.
[22]	MAHLAKÖIV T, HERNANDEZ P, GRONKE K, et al. Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infections[J].PLoS Pathog, 2015, 11(4):1004782.
[23]	PESTKA S, KRAUSE C D, WALTER M R.Interferons, interferon-like cytokines, and their receptors[J].Immunol Rev, 2004, 202:8-32.
[24]	MARKS Z R C, CAMPBELL N, DEWEERD N A, et al. Properties and functions of the novel type I interferon epsilon[J].Semin Immunol, 2019, 43:101328.
[25]	MATSUMIYA T, XING F, EBINA M, et al. Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-ε expression[J].J Immunol, 2013, 191(4):1907-1915.
[26]	PENG F W, DUAN Z J, ZHENG L S, et al. Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes[J].Protein Expr Purif, 2007, 53(2):356-362.
[27]	XI Y, DAY S L, JACKSON R J, et al. Role of novel type I interferon epsilon in viral infection and mucosal immunity[J].Mucosal Immunol, 2012, 5(6):610-622.
[28]	FUNG K Y, MANGAN N E, CUMMING H, et al. Interferon-ε protects the female reproductive tract from viral and bacterial infection[J].Science, 2013, 339(6123):1088-1092.
[29]	STIFTER S A, MATTHEWS A Y, MANGAN N E, et al. Defining the distinct, intrinsic properties of the novel type I interferon, IFNε[J].J Biol Chem, 2018, 293(9):3168-3179.
[30]	HARDY M P, OWCZAREK C M, JERMⅡN L S, et al. Characterization of the type I interferon locus and identification of novel genes[J].Genomics, 2004, 84(2):331-345.
[31]	谢秋波.小鼠IFN-ε的可溶性表达及其对绝经后泌尿系感染的作用[D].重庆:第三军医大学, 2017.XIE Q B.Soluble expression of murine IFN-ε and its effects on postmenopausal urinary tract infection in mice[D].Chongqing:Third Military Medical University, 2017.(in Chinese)
[32]	SARODE B S.人lambda1和epsilon干扰素基因的克隆和在WI-38细胞中的表达及其活性比较[D].苏州:苏州大学, 2007.SARODE B S.Research on cloning, eukaryotic expression and detection of biological activity of human interferon-λ1 and human interferon-ε[D].Suzhou:Suzhou University, 2007.(in Chinese)
[33]	ALLAN P, JARVIS.Interferon epsilon:US, P4614651[P].1981.
[34]	ROY H L, PANG.Assay for interferon epsilon:CA, 1244345A[P].1984.
[35]	Genentech Inc.Human interferon-epsilon:a type I interferon:CA, 2311681A1[P].1999-06-17.
[36]	COURET J, TASKER C, KIM J, et al. Differential regulation of IFNα, IFNβ and IFNε gene expression in human cervical epithelial cells[J].Cell Biosci, 2017, 7:57.
[37]	DEMERS A, KANG G, MA F, et al. The mucosal expression pattern of interferon-ε in rhesus macaques[J].J Leukoc Biol, 2014, 96(6):1101-1107.
[38]	SANG Y M, ROWLAND R R R, HESSE R A, et al. Differential expression and activity of the porcine type I interferon family[J].Physiol Genomics, 2010, 42(2):248-258.
[39]	CUMMING H E, BOURKE N M.Type I IFNs in the female reproductive tract:the first line of defense in an ever-changing battleground[J].J Leukoc Biol, 2019, 105(2):353-361.
[40]	GUAN W J, NI Z Y, HU Y, et al. Clinical characteristics of coronavirus disease 2019 in China[J].N Engl J Med, 2020, 382(18):1708-1720.
[41]	LIVINGSTON E, BUCHER K.Coronavirus disease 2019(COVID-19) in Italy[J].JAMA, 2020, 323(14):1335.
[42]	GRASSELLI G, ZANGRILLO A, ZANELLA A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy[J].JAMA, 2020, 323(16):1574-1581.
[43]	BIENVENU L A, NOONAN J, WANG X W, et al. Higher mortality of COVID-19 in males:sex differences in immune response and cardiovascular comorbidities[J].Cardiovasc Res, 2020, 116(14):2197-2206.
[44]	AFSAR C U, AFSAR S.SARS-CoV-2(Covid-19):interferon-epsilon may be responsible of decreased mortality in females[J].J Reprod Immunol, 2020, 141:103154.
[45]	SAMA I E, RAVERA A, SANTEMA B T, et al. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors[J].Eur Heart J, 2020, 41(19):1810-1817.
[46]	SAMUEL R M, MAJD H, RICHTER M N, et al. Androgen signaling regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men[J].Cell Stem Cell, 2020, 27(6):876-889.
[47]	YE Q, WANG B L, MAO J H.The pathogenesis and treatment of the ‘Cytokine Storm’ in COVID-19[J].J Infect, 2020, 80(6):607-613.
[48]	LIU X L, DIEDRICHS-MOHRING M, WILDNER G.The role of IFN-alpha in experimental and clinical uveitis[J].Ocul Immunol Inflamm, 2019, 27(1):23-33.
[49]	REMPEL J D, KRUEGER C, UHANOVA J, et al. The impact of gender on interferon-associated depression and anxiety[J].J Interferon Cytokine Res, 2019, 39(7):416-420.
[50]	DAFNY N.Is interferon-alpha a neuromodulator?[J].Brain Res Brain Res Rev, 1998, 26(1):1-15.
[51]	THANEY V E, KAUL M.Type I Interferons in NeuroHIV[J].Viral Immunol, 2019, 32(1):7-14.
[52]	HOYO-BECERRA C, SCHLAAK J F, HERMANN D M.Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation[J].Brain Behav Immun, 2014, 42:222-231.
[53]	WICHERS M C, KENIS G, KOEK G H, et al. Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol[J].J Psychosom Res, 2007, 62(2):207-214.
[54]	DEDONI S, OLIANAS M C, INGIANNI A, et al. Type I interferons impair BDNF-induced cell signaling and neurotrophic activity in differentiated human SH-SY5Y neuroblastoma cells and mouse primary cortical neurons[J].J Neurochem, 2012, 122(1):58-71.
[55]	LOKESHWAR V B, SELZER M G.Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells[J].J Biol Chem, 2000, 275(36):27641-27649.
[56]	GUO Y L, GAO M C, BAO J, et al. Molecular cloning and characterization of a novel bovine IFN-ε[J].Gene, 2015, 558(1):25-30.
[57]	GUO Y L, SONG Z F, CHENG X T, et al. Molecular and functional characterization of ovis aries IFN-epsilon[J].Mol Immunol, 2020, 119:1-7.
[58]	TASKER C, SUBBIAN S, GAO P.IFN-ε protects primary macrophages against HIV infection[J].JCI Insight, 2016, 1(20):e88255.
[59]	YANG L M, XU L, LI Y, et al. Molecular and functional characterization of canine interferon-epsilon[J].J Interferon Cytokine Res, 2013, 33(12):760-768.
[60]	ABDEL-FATTAH M, SAEED H, EL-SHENNAWY L, et al. The Arabian camel, Camelus dromedarius interferon epsilon:functional expression, in vitro refolding, purification and cytotoxicity on breast cancer cell lines[J].PLoS One, 2019, 14(9):213880.
[61]	MASTRANGELI R, PALINSKY W, BIERAU H.How unique is interferon-β within the type I interferon family?[J].Cytokine, 2018, 111:206-208.
[62]	MOGENSEN K E, LEWERENZ M, REBOUL J, et al. The type I interferon receptor:structure, function, and evolution of a family business[J].J Interferon Cytokine Res, 1999, 19(10):1069-1098.
[63]	HERMANT P, FRANCIUS C, CLOTMAN F, et al. IFN-ε is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines[J].PLoS One, 2013, 8(8):e71320.
[64]	ANDREAKOS E, TSIODRAS S.COVID-19:lambda interferon against viral load and hyperinflammation[J].EMBO Mol Med, 2020, 12(6):12465.
[65]	SAMUDRALA P K, KUMAR P, CHOUDHARY K, et al. Virology, pathogenesis, diagnosis and in-line treatment of COVID-19[J].Eur J Pharmacol, 2020, 883:173375.
[66]	HUNG I F N, LUNG K C, TSO E Y K, et al. Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19:an open-label, randomised, phase 2 trial[J].Lancet, 2020, 395(10238):1695-1704.
[67]	SCHREIBER G.The role of type I interferons in the pathogenesis and treatment of COVID-19[J].Front Immunol, 2020, 11:595739.

Research Progress of Interferon-ε

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