干扰素-ε研究进展

doi:10.11843/j.issn.0366-6964.2021.011.004

Abstract

Abstract: Interferon-epsilon (IFN-ε) is a novel type I interferons (IFNs), which is also a type of cytokines secreted by varieties of cells. It is a glycoprotein, which can exert antiviral, immunoregulatory and anti-tumor biological activities. However, unlike other type I IFNs, IFN-ε is constitutively expressed by mucous epithelial cell and regulated by hormones without virus induction. IFN-ε plays an important role in mucosal immunity. At present, there are few reports on related studies. In this paper, we reviewed the research progress of IFN-ε origin of human and different animals, distribution in vivo, protection of reproductive system, regulation of nervous system and antiviral effect, to further understand and develop new IFNs reagent.

Key words: interferon-ε, cytokines, constitutive expression, antiviral activity

CLC Number:

S852.4

ZHANG Hailing, LIAN Shizhen, ZHANG Dongliang, BAI Xue, ZHANG Shasha, ZHANG Lei, LI Wei, LIU Fangyuan, WANG Han, HU Bo, LU Shiying. Research Progress of Interferon-ε[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(11): 3023-3029.

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Research Progress of Interferon-ε

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