基于网络药理学探讨葛根芩连汤治疗猪腹泻的靶点与通路

doi:10.11843/j.issn.0366-6964.2020.11.026

Abstract

Abstract: This experiment was conducted to explore the mechanism of Gegen Qinlian decoction in treating swine diarrhea. The chemical composition and targets of Gegen Qinlian decoction were searched by the analysis of the traditional Chinese medicine system pharmacology platform (TCMSP). The software of Cytoscape 3.7.1 was used to construct and analyze compound-targets networks, protein-protein interaction (PPI) network and key targets-signaling pathway network. The results showed that 60 active compounds including daidzein, puerarin, oroxindin and formononetin were obtained after screening. The compounds acted on 206 targets, among which TP53, TNF, IL-6, IL-8, Jun and STAT3 were the key targets. These key targets involve in PI3K-Akt signaling pathway, Viral carcinogenesis, and so on. Based on the results of network pharmacological analysis, Gegen Qinlian decoction may regulate diarrhea and fever through TP53, TNF, IL-6, IL-8, Jun, STAT3 and other targets. The paper provides theoretical basis and clues for the further study of Gegen Qinlian decoction in the treatment of swine diarrhea.

Key words: Gegen Qinlian decoction, swine, diarrhea, network pharmacology

CLC Number:

S853.74

WANG Chunhua, SUN Xuefang. The Target and Pathway of Gegen Qinlian Decoction in Treating Swine Diarrhea Based on Network Pharmacology[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(11): 2875-2885.

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The Target and Pathway of Gegen Qinlian Decoction in Treating Swine Diarrhea Based on Network Pharmacology

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