基因间长链非编码RNA在骨骼肌发育中的研究进展

doi:10.11843/j.issn.0366-6964.2019.03.001

Abstract

Abstract:

Skeletal muscle is the most important part of the animal body, maintaining the body movement and providing human with the necessary meat products. The difference in the regulatory mechanisms during skeletal muscle growth and development can cause differences in muscle yield and meat quality. Long intergenic noncoding RNA (lincRNA) is a class of RNA located in the intergenic region, which is longer than 200 nt and has a lower protein-encoding potential. The expression of lincRNA has space-time specificity and tissue specificity, and exerts biological functions in epigenetic regulation, transcriptional regulation and post-transcriptional regulation.In recent years, the popular high-throughput RNA-seq technology has identified a number of lincRNA associated with skeletal muscle development, model organism studies such as human and mouse have shown that lincRNA is involved in the regulation of skeletal muscle growth and development, muscle cell growth and proliferation, migration, differentiation and apoptosis. In this review,we summarized the evolutionary conservation,the characteristics of lincRNA, and its research progress in the regulation of skeletal muscle development and domestic animal.

CLC Number:

S813.1

BAO Jingjing, PU Yabin, MA Yuehui, ZHAO Qianjun. Research Progress of Long Intergenic Noncoding RNA in Skeletal Muscle Development[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(3): 461-473.

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Research Progress of Long Intergenic Noncoding RNA in Skeletal Muscle Development

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