布鲁氏菌毒力因子与胞内存活机制研究进展

doi:10.11843/j.issn.0366-6964.2025.04.010

Abstract

Abstract:

Brucellosis is an important zoonotic disease that is prevalent worldwide, while causing numerous economic losses to animal husbandry, it also poses a serious threat to human health and public health security. Brucella can use various strategies for immune system evasion, not only resisting the bactericidal effect of phagocytic cells, but also creating a favorable microenvironment in host cells for its survival, ultimately leading to persistent chronic infection. These characteristics pose significant challenges to the prevention and control of brucellosis. As a prerequisite for further understanding and preventing brucellosis, the virulence process, intracellular survival, and immune evasion of Brucella have always been the focus of attention. So, this work reviewed the Brucella pathogenesis research progress from perspectives of virulence factors, intracellular survival, and immune evasion mechanism, providing reference for future development of novel safe, efficient prevention and control products by elucidating Brucella pathogenesis.

Key words: Brucella, virulence factor, intracellular survival, pathogenesis

CLC Number:

R378.5

YOU Liuchao, YIN Hao, TAO Zhengyu, HUANG Rong, FU Lei, CHU Yuefeng. Research Progress in the Virulence Factors and Intracellular Survival Mechanism of Brucella[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(4): 1575-1593.

Figures/Tables 4

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效应蛋白 Effector protein	B. abortus中的开放阅读框 Open reading frames in B. abortus	氨基酸数 Amino acid number	宿主靶标 Target of host	功能 Function	方法 Method	参考文献 Reference
RicA	BAB1_1279	175	Rab2	调控囊泡运输	TEM1	[40]
VceA	BAB1_1652	105	未知	未知	CyaA，TEM1	[36]
VceC	BAB1_1058	418	Bip/Grp78	激活未折叠蛋白反应	CyaA，TEM1	[37]
BPE005	BAB1_2005	153	未知	未知	CyaA	[31]
BPE043	BAB1_1043	1553	未知	未知	CyaA	[31]
BPE275	BAB1_1275	253	未知	未知	CyaA	[31]
BPE123	BAB1_0123	153	未知	未知	CyaA	[31]
BtpA/TcpB/Btp1	BAB1_0279	250	MAL	抑制TLR通路	CyaA	[33, 49]
BtpB	BAB1_0756	292	未知	抑制TLR通路	CyaA，TEM1	[33]
BspA	BAB1_0678	191	未知	抑制分泌通路	CyaA，TEM1	[30]
BspB	BAB1_0712	187	未知	抑制分泌通路	CyaA，TEM1	[30]
BspC	BAB1_0847	137	未知	未知	CyaA，TEM1	[30]
BspE	BAB1_1671	117	未知	未知	CyaA，TEM1	[30]
BspF	BAB1_1948	428	未知	抑制分泌通路	CyaA，TEM1	[30]
SepA	BAB1_1492	130	未知	抑制BCV与溶酶体融合	CyaA，TEM1	[34]
NyxA	BAB1_0296	129	SENP3	抑制SENP3核定位	TEM1	[47]
NyxB	BAB1_1101	90	SENP3	抑制SENP3核定位	TEM1	[47]
NpeA	BAB2_0195	223	N-WASP	促进增殖憩室形成	In-silico analysis	[48]

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Research Progress in the Virulence Factors and Intracellular Survival Mechanism of Brucella

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