围产期使用抗菌药物对PRRSV阳性猪场母猪和仔猪生产性能的影响

doi:10.11843/j.issn.0366-6964.2024.06.045

Abstract

Abstract:

The present study aimed to assess the effect of antimicrobial use in the perinatal period on the performance of sows and piglets in PRRSV-positive farms. A total of 280 near-term pregnant sows were selected from a large-scale PRRSV-positive pig farm in Guangxi and divided into five groups randomly. During the perinatal period, the sows in each group were administered veterinary antibiotics such as tilmicosin, tiamulin, doxycycline, and tylvalosin commonly used in veterinary medicine, while the control group received no antibiotic treatment. The anterior vena cava blood of weaned piglets in each group was collected for PRRSV antigen and antibody detection to assess the effectiveness of the antibiotics in preventing PRRSV infection in piglets. The number and ratio of diarrhea cases were recorded for each group of weaned piglets to investigate the preventive effect of common antibiotics on piglet diarrhea. The weaning interval of weaned sows and the estrus mating rate within 7 and 10 days after weaning were counted in each group, and the production indexes such as the number of weaning per litter, weaning survival rate and weaning weight of piglets in each group were counted to evaluate the impact of perinatal health care with commonly used antibiotics on the production performance of sows and piglets and to calculate the economic benefits of using drugs. The weaned piglets in the tylvalosin and tilmicosin groups showed a PRRSV nucleic acid positivity rate of 0%, and their PRRS antibody levels were significantly higher than those in the control group. The tylvalosin group exhibited a lower diarrhea rate in piglets compared to the other treatment groups and the control group. Statistical analysis of relevant production indicators showed that compared to other groups, the weaning survival rate and weaning weight of piglets in the tylvalosin groups were the highest, the weaning interval of sows was the shortest, and the average litter loss was lower. In summary, this study assessed the impact of perinatal health care with antibiotics commonly used in veterinary clinic on the production performance of sows and piglets in PRRSV-infected pig farms. It was found that using tylvalosin can inhibit the vertical transmission of PRRSV, enhance piglet antibody levels, and significantly reduce the weaned piglet diarrhea rate. In addition, the use of tylvalosin significantly improved weaning survival rate and weaning weight of piglets, shortened the separation interval of sows, and reduced the loss of litter assets. The initiation of this study provides crucial experimental data and theoretical support for effective antimicrobial use in large-scale PRRSV-positive pig farms, and provided necessary supplementary measures for realizing cost reduction and efficiency increase in large-scale pig farms under the background of PRRSV pandemic.

Key words: porcine reproductive and respiratory syndrome, large-scale pig farms, perinatal, antibiotics, tylvalosin

CLC Number:

S852.659.6

Shuqi XIAO, Jun LIU, Yingtong FENG, Yang LI, Lele XU. Effect of Antimicrobial Use in the Perinatal Period on the Performance of Sows and Piglets in PRRSV-positive Farms[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(6): 2751-2760.

Figures/Tables 8

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References 21

1	杨汉春, 周磊. 2022年猪病流行情况与2023年流行趋势及防控对策[J]. 猪业科学, 2023, 40 (2): 58- 60.
	YANG H C , ZHOU L . The epidemic situation of swine disease in 2022 and the epidemic trend and prevention and control measures in 2023[J]. Swine Industry Science, 2023, 40 (2): 58- 60.
2	LI Y , XU L L , JIAO D , et al. Genomic similarity and antibody-dependent enhancement of immune serum potentially affect the protective efficacy of commercial MLV vaccines against NADC30-like PRRSV[J]. Virol Sin, 2023, 38 (5): 813- 826. doi: 10.1016/j.virs.2023.08.010
3	高德臣. 猪繁殖与呼吸综合征流行情况及其疫苗的研究与应用[J]. 中国畜禽种业, 2023, 19 (2): 76- 79. doi: 10.3969/j.issn.1673-4556.2023.02.018
	GAO D C . Porcine reproductive and respiratory syndrome prevalence and its vaccine research and application[J]. The Chinese Livestock and Poultry Breeding, 2023, 19 (2): 76- 79. doi: 10.3969/j.issn.1673-4556.2023.02.018
4	饶继红, 何彪, 涂长春, 等. 健康断奶仔猪携带猪繁殖与呼吸综合征病毒的流行病学调查[J]. 安徽农业科学, 2019, 47 (11): 111-114, 118.
	RAO J H , HE B , TU C C , et al. Epidemiological investigation of porcine reproductive and respiratory syndrome virus in healthy weaned piglets[J]. Journal of Anhui Agricultural Sciences, 2019, 47 (11): 111-114, 118.
5	RODRIGUEZ A L , FOWLER V L , HUETHER M , et al. Effects of a water-soluble formulation of tylvalosin on disease caused by porcine reproductive and respiratory syndrome virus alone in sows or in combination with Mycoplasma hyopneumoniae in piglets[J]. BMC Vet Res, 2023, 19 (1): 31. doi: 10.1186/s12917-023-03571-x
6	朱利俊, 张锦国, 田继承, 等. 替米考星对初产母猪蓝耳病的效果观察[J]. 畜牧兽医科学(电子版), 2017, (9): 4- 5.
	ZHU L J , ZHANG J G , TIAN J C , et al. Effect of tilmicosin on PRRS in primiparous sows[J]. Graziery Veterinary Sciences (Electronic Version), 2017, (9): 4- 5.
7	POONSUK K , ARUNORAT J , WOONWONG Y , et al. Antiviral activity of four commercial tilmicosin preparations against porcine reproductive and respiratory syndrome virus (PRRSV): an in vitro study[J]. Thai J Vet Med, 2014, 44 (2): 217- 222. doi: 10.56808/2985-1130.2563
8	SHI H , LUO W T , WANG S Y , et al. Therapeutic efficacy of tylvalosin combined with Poria cocos polysaccharides against porcine reproductive and respiratory syndrome[J]. Front Vet Sci, 2023, 10, 1242146. doi: 10.3389/fvets.2023.1242146
9	LI Y M , WU Z C , LIU K , et al. Doxycycline enhances adsorption and inhibits early-stage replication of porcine reproductive and respiratory syndrome virus in vitro[J]. FEMS Microbiol Lett, 2017, 364 (17): fnx170.
10	CAMPBELL J M , CRENSHAW J D , POLO J . The biological stress of early weaned piglets[J]. J Anim Sci Biotechnol, 2013, 4 (1): 19. doi: 10.1186/2049-1891-4-19
11	ZHENG L , DUARTE M E , SEVAROLLI LOFTUS A , et al. Intestinal health of pigs upon weaning: challenges and nutritional intervention[J]. Front Vet Sci, 2021, 8, 628258. doi: 10.3389/fvets.2021.628258
12	张帅, 刘媛, 王迈, 等. 泰万菌素对猪繁殖与呼吸综合征的防控效果试验[J]. 中国动物检疫, 2022, 39 (4): 113- 119.
	ZHANG S , LIU Y , WANG M , et al. Evaluation of prevention and control effect of tylvalosin on PRRS[J]. China Animal Health Inspection, 2022, 39 (4): 113- 119.
13	MA X , WANG P X , ZHANG R T , et al. A NADC30-like PRRSV causes serious intestinal infections and tropism in piglets[J]. Vet Microbiol, 2022, 268, 109397.
14	FENG Y T , GUO X Y , TIAN H , et al. Induction of HOXA3 by porcine reproductive and respiratory syndrome virus inhibits type Ⅰ interferon response through negative regulation of HO-1 transcription[J]. J Virol, 2022, 96 (3): e0186321.
15	ZHENG Z F , FU X L , LING X , et al. Host cells actively resist porcine reproductive and respiratory syndrome virus infection via the IRF8-MicroRNA-10a-SRP14 regulatory pathway[J]. J Virol, 2022, 96 (7): e0000322.
16	XU K , ZHOU Y R , MU Y L , et al. CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance[J]. eLife, 2020, 9, e57132.
17	WEI Y , ZOU C C , ZENG S Y , et al. Characterization of porcine tripartite motif genes as host restriction factors against PRRSV and PEDV infection[J]. Virus Res, 2019, 270, 197647.
18	POWELL L F , CHENEY T E A , WILLIAMSON S , et al. A prevalence study of Salmonella spp., Yersinia spp., Toxoplasma gondii and porcine reproductive and respiratory syndrome virus in UK pigs at slaughter[J]. Epidemiol Infect, 2016, 144 (7): 1538- 1549.
19	李剑静. 1例仔猪混合感染PRRSV、PCV与大肠杆菌的诊断及基因组比较分析[J]. 养殖与饲料, 2023, 22 (2): 13- 20.
	LI J J . Diagnosis and comparative analysis of genomes of a piglet with mixed infection with PRRSV, PCV and Escherichia coli[J]. Animals Breeding and Feed, 2023, 22 (2): 13- 20.
20	付霞丽, 郑紫方, 李洋, 等. PRRSV感染继发细菌性病原的致病性及耐药性分析[J]. 中国兽医学报, 2021, 41 (8): 1470- 1475.
	FU X L , ZHENG Z F , LI Y , et al. Analysis of pathogenicity and drug resistance of bacterial pathogens after PRRSV infection[J]. Chinese Journal of Veterinary Science, 2021, 41 (8): 1470- 1475.
21	曲向阳, 罗勇, 王巍. 哺乳母猪饲料中添加替米考星防控仔猪呼吸系统疾病综合征的效果评估[J]. 畜禽业, 2012, 23 (1): 56- 58.
	QU X Y , LUO Y , WANG W . Evaluation of the effect of tilmicosin supplementation in lactating sow feed for the prevention and control of respiratory disease syndrome in piglets[J]. Livestock and Poultry Industry, 2012, 23 (1): 56- 58.

组别 Group	断奶母猪数 Number of weaned sows	7 d内配种数 Number of mating in 7 days	10 d内配种数 Number of mating in 10 days	7 d断配率/% 7-day mating rate of sows	10 d断配率/% 10-day mating rate of sows
替米考星 Tilmicosin	55	46	48	83.64	87.27
泰妙菌素 Tiamulin	55	43	46	78.18	83.64
多西环素 Doxycycline	56	47	49	83.93	87.50
泰万菌素 Tylvalosin	56	49	50	87.50	89.29
对照组 Control	55	44	47	80.00	85.45

组别 Group	药物成本/(元·窝^-1) Cost of drugs (RMB per litter)	窝均损失资产/(元·窝^-1) Average loss of assets (RMB per litter)
替米考星Tilmicosin	35.00	435.0
泰妙菌素Tiamulin	18.76	435.0
多西环素Doxycycline	11.76	580.0
泰万菌素Tylvalosin	84.00	197.2
对照组Control	0.00	464.0

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Effect of Antimicrobial Use in the Perinatal Period on the Performance of Sows and Piglets in PRRSV-positive Farms

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组别 Group	分娩后时间/d Days after parturition												腹泻率/% Diarrhea rate
组别 Group	0	1	2	3	4	5	6	7	8	9	10	11	腹泻率/% Diarrhea rate
替米考星 Tilmicosin	0	1	1	8	18	11	8	10	2	1	1	0	32.14
泰妙菌素 Tiamulin	0	4	14	20	11	7	3	3	2	1	0	0	35.71
多西环素 Doxycycline	0	1	9	12	16	19	9	6	5	0	0	0	33.93
泰万菌素 Tylvalosin	0	2	5	7	15	9	7	8	4	2	1	0	26.79
对照组 Control	0	1	7	18	11	8	10	2	1	1	0	0	32.14