脯氨酸羟化酶(PHDs)对动物骨骼肌发育和脂肪沉积的调控作用及其机制

doi:10.11843/j.issn.0366-6964.2024.03.001

Abstract

Abstract: In livestock and poultry production,skeletal muscle development and fat deposition have an important effect on product quality. Regulating skeletal muscle development and fat deposition to improve carcass quality and meat quality of livestock and poultry is of great significance for improving the quality and efficiency of breeding industry. Proline hydroxylases(PHDs) are a class of non-heme iron-dependent dioxygenases that not only act as an important regulator of hypoxic-inducing factor signaling pathway,but also participate in many physiological functions by regulating oxygen adaptation level in cells,apoptosis,cell metabolism and cell transport. On the basis of introducing the physiological function and activity regulation of PHD,this paper summarized the regulatory role of PHDs in animal skeletal muscle development and fat deposition,and analyzed the possible mechanism of its role,in order to provide new ideas and targets for improving the quality of livestock and poultry products by regulating animal skeletal muscle development and fat deposition.

Key words: proline hydroxylases, skeletal muscle development, fat deposition, regulatory roles

CLC Number:

S852.2

LIANG Shuyi, LI Fan, JIANG Qingyan, WANG Songbo. Regulation and Mechanism of Proline Hydroxylases(PHDs) on Skeletal Muscle Development and Fat Deposition in Animals[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 867-873.

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Regulation and Mechanism of Proline Hydroxylases(PHDs) on Skeletal Muscle Development and Fat Deposition in Animals

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