疱疹病毒ICP22蛋白研究进展

doi:10.11843/j.issn.0366-6964.2021.002

Abstract

Abstract: Herpesvirus is a type of double-stranded DNA virus with a capsule structure, which is mainly composed of a double-stranded DNA genome, capsid, tegument, and envelope. At present, more than 100 types of herpes virus have been found, which can be divided into α-, β-, γ-herpesvirus subfamilies. It infects a wide range of hosts, such as amphibians, birds, mammals, primates and humans, and so on. It mainly damages the skin, mucous membrane, and nerve tissue, and seriously affects the health of human and other animal. Infected cell protein 22 (ICP22) is a multifunctional protein encoded by US1 or its homologous genes and can interact with cells and/or viral components to exert a wide range of functions. It can be involved in the establishment of latent infection period of viruses, the interaction with RNA polymerase Ⅱ (RNA Pol Ⅱ) to affect the transcription of viral and host genes, the formation of viral-induced chaperone-enriched (VICE) regions, and the nuclear budding of progeny viral particles, involving apoptosis, autophagy, and antiviral response, etc. This article reviews the research progress of herpes virus US1 and its homologous genes, and the encoding protein ICP22. We hope it will provide new ideas and directions for further research on the interaction mechanism of ICP22 with other virus and host proteins involved in physiological and pathological processes, and we also hope it will provide a certain reference value for the research of animal herpes virus, especially the new drugs targeting ICP22.

Key words: herpesvirus, ICP22, transcriptional regulation, nuclear egress, apoptosis, autophagy

CLC Number:

S852.659.1

LI Yangguang, WU Ying, WANG Mingshu, CHENG Anchun. Research Progress of Herpes Virus ICP22 Protein[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(1): 9-18.

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Research Progress of Herpes Virus ICP22 Protein

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