羊毛弯曲及毛囊发育相关生物学机制研究进展

doi:10.11843/j.issn.0366-6964.2020.01.002

Abstract

Abstract: Wool curvature is one of the key factors affecting wool quality. The decrease of wool curvature and the change of wool strand from compactness to fluffy will lead to the decline of wool quality, which will affect the value of fur. Hair follicle is a skin accessory organ that regulates hair growth and plays an important role in the formation of curvature of hair. In recent years, some progress had been made in the study of curvature formation of hair fibers in sheep, mice and other animals, as well as in the regulation of hair follicle development. In this paper, the characteristics of wool fiber structure were introduced, and the important regulatory signaling pathways related to hair follicle development and their effects on hair curvature were elaborated. In summary, the research progress of wool curvature related genes and proteins were reviewed. The biological mechanism of wool curvature and hair follicle development were summarized in order to provide theoretical basis for the study of molecular mechanism of wool curvature and hair follicle development, and to provide some references for improving wool curvature characteristics.

Key words: wool curvature, hair follicle development, protein, mechanism

CLC Number:

S826.2

DING Yangyang, LIU Zhanfa, MENG Xiangren, MA Yuehui, PU Yabin, ZHAO Qianjun. Research Progress on Biological Mechanisms Related to Wool Bending and Hair Follicle Development[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(1): 9-17.

References 58

[1]	PRIESTLEY G C.Histological studies of the skin follicle types of the rat with special reference to the structure of the Huxley layer[J].J Anat,1967,101(3):491-504.
[2]	HARLAND D P,VERNON J A,WOODS J L,et al.Intrinsic curvature in wool fibres is determined by the relative length of orthocortical and paracortical cells[J].J Exp Biol,2018,221(6):jeb172312.
[3]	PLOWMAN J E,HARLAND D P,SCOBIE D R,et al.Differences between ultrastructure and protein composition in straight hair fibres[J].Zoology (Jena),2019,133:40-53.
[4]	MARSHALL R C,ORWIN D F G,GILLESPIE J M.Structure and biochemistry of mammalian hard keratin[J].Electron Microsc Rev,1991,4(1):47-83.
[5]	TEH M T,BLAYDON D,GHALI L R,et al.Role for WNT16B in human epidermal keratinocyte proliferation and differentiation[J].J Cell Sci,2007,120(2):330-339.
[6]	CIECHANOVER A,ORIAN A,SCHWARTZ A L.Ubiquitin-mediated proteolysis:biological regulation via destruction[J].BioEssays,2000,22(5):442-451.
[7]	DHANANJAYAN S C,ISMAIL A,NAWAZ Z.Ubiquitin and control of transcription[J].Essays Biochem,2005,41:69-80.
[8]	IZZI L,ATTISANO L.Regulation of the TGFβ signalling pathway by ubiquitin-mediated degradation[J]. Oncogene, 2004, 23(11):2071-2078.
[9]	YI R,O'CARROLL D,PASOLLI H A,et al.Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs[J].Nat Genet,2006,38(3):356-362.
[10]	WANG J K,CUI K,YANG Z,et al.Transcriptome analysis of improved wool production in skin-specific transgenic sheep overexpressing ovine β-catenin[J].Int J Mol Sci,2019,20(3):620.
[11]	LIM X,TAN S H,YU K L,et al.Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/β-catenin signaling[J].Proc Natl Acad Sci U S A,2016,113(11):E1498-E1505.
[12]	YESUDIAN P D.Hair abnormalities in genetic disorders of junctions[J].Int J Trichol,2009,1(1):15-17.
[13]	SONG D L,LIU X Y,LIU R J,et al.Connexin 43 hemichannel regulates H9c2 cell proliferation by modulating intracellular ATP and[Ca2+] [J].Acta Biochim Biophys Sin (Shanghai),2010,42(7):472-482.
[14]	HAN Y S,ZHANG P J,CHEN T,et al.Connexin43 expression increases in the epithelium and stroma along the colonic neoplastic progression pathway:implications for its oncogenic role[J].Gastroenterol Res Pract,2011,2011:561719.
[15]	MCNEILL H.Planar cell polarity:keeping hairs straight is not so simple[J].Cold Spring Harb Perspect Biol,2010,2(2):a003376.
[16]	PAN R H,XIE F Y,CHEN H M,et al.Salvianolic acid B reverses the epithelial-to-mesenchymal transition of HK-2 cells that is induced by transforming growth factor-β[J].Arch Pharm Res,2011,34(3):477-483.
[17]	RYBAK A,FUCHS H,HADIAN K,et al.The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2[J].Nat Cell Biol,2009,11(12):1411-1420.
[18]	ALSHAIBI H F,AHMED F,BUCKLE C,et al.The BMP antagonist Noggin is produced by osteoblasts in response to the presence of prostate cancer cells[J].Biotechnol Appl Biochem,2018,65(3):407-418.
[19]	SONG L L,CUI Y,YU S J,et al.Expression characteristics of BMP2,BMPR-IA and Noggin in different stages of hair follicle in yak skin[J].Gen Comp Endocrinol,2018,260:18-24.
[20]	WU P,ZHANG Y M,XING Y Z,et al.The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles[J].Cell Commun Signal,2019,17(1):16.
[21]	JIN M,ZHANG J Y,CHU M X,et al.Cashmere growth control in Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 and decorin genes[J].Asian-Australas J Anim Sci,2018,31(5):650-657.
[22]	VAN STEENSEL M A M,VAN GEEL M,BADELOE S,et al.Molecular pathways involved in hair follicle tumor formation:all about mammalian target of rapamycin?[J].Exp Dermatol,2009,18(2):185-191.
[23]	BESSIS D,LUONG M S,BLANC P,et al.Straight hair associated with interferon-alfa plus ribavirin in hepatitis C infection[J].Br J Dermatol,2002,147(2):392-393.
[24]	LI W R,LIU C X,ZHANG X M,et al.CRISPR/Cas9-mediated loss of FGF5 function increases wool staple length in sheep[J].FEBS J,2017,284(17):2764-2773.
[25]	PIAO J,XU C L,PIAO J A,et al.Expression analysis of proteasome maturation protein (POMP) gene in Liaoning Cashmere goat[J].Anim Biotechnol,2019,
[26]	ZHANG R,WU H P,LIAN Z X.Bioinformatics analysis of evolutionary characteristics and biochemical structure of FGF5 Gene in sheep[J].Gene,2019,702:123-132.
[27]	YOSHIZAWA Y,WADA K,SHIOMI G,et al.A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster[J].Mamm Genome,2015,26(11-12):630-637.
[28]	LEE K H,CHOI D,JEONG S I,et al.Eclipta prostrata promotes the induction of anagen,sustains the anagen phase through regulation of FGF-7 and FGF-5[J].Pharm Biol,2019,57(1):105-111.
[29]	ZHANG H H,NAN W X,WANG S Y,et al.Balance between fibroblast growth factor 10 and secreted frizzled-relate protein-1 controls the development of hair follicle by competitively regulating β-catenin signaling[J].Biomed Pharmacother, 2018,103:1531-1537.
[30]	吴晋强,曹校瑞,闫瑞琴,等.FGF21及其受体FGFR1和FGFR2在小鼠毛囊第1生长周期的表达[J].畜牧兽医学报, 2019,50(3):534-543.WU J Q,CAO X R,YAN R Q,et al.Expression of FGF21 and receptors FGFR1,FGFR2 in the first hair follicle growth cycle of mice[J].Acta Veterinaria et Zootechnica Sinica,2019,50(3):534-543.(in Chinese)
[31]	GONG H,ZHOU H T,MCKENZIE G W,et al.An updated nomenclature for keratin-associated proteins (KAPs)[J].Int J Biol Sci,2012,8(2):258-264.
[32]	ROGERS M A,LANGBEIN L,PRAETZEL-WUNDER S,et al.Human hair keratin-associated proteins (KAPs)[J].Int Rev Cytol,2006,251(3):209-263.
[33]	BAI L R,WANG J,ZHOU H T,et al.Identification of ovine KRTAP28-1 and its association with wool fibre diameter[J].Animals (Basel),2019,9(4):142.
[34]	WANG J Q,CHE L J,HICKFORD J,et al.Identification of the caprine keratin-associated protein 20-2(KAP20-2) gene and its effect on cashmere traits[J].Genes (Basel),2017,8(11):328.
[35]	BAI L R,GONG H,ZHOU H T,et al.A nucleotide substitution in the ovine KAP20-2 gene leads to a premature stop codon that affects wool fibre curvature[J].Anim Genet,2018,49(4):357-358.
[36]	ZHOU H T,GONG H,WANG J Q,et al.Identification of four new gene members of the KAP6 gene family in sheep[J].Sci Rep,2016,6:24074.
[37]	LI S B,ZHOU H T,GONG H,et al.Identification of the ovine keratin-associated protein 22-1(KAP22-1) gene and its effect on wool traits[J].Genes (Basel),2017,8(1):27.
[38]	LI S B,ZHOU H T,GONG H,et al.Identification of the ovine keratin-associated protein 26-1 gene and its association with variation in wool traits[J].Genes (Basel),2017,8(9):225.
[39]	GONG H,ZHOU H T,BAI L R,et al.Associations between variation in the ovine high glycine-tyrosine keratin-associated protein gene KRTAP20-1 and wool traits[J].J Anim Sci,2019,97(2):587-595.
[40]	FANG Y,LIU W J,ZHANG F Q,et al.The polymorphism of a novel mutation of KAP13.1 gene and its associations with cashmere traits on Xinjiang local goat breed in China[J].Asian J Anim Vet Adv,2010,5(1):34-42.
[41]	LIU H Y,LI N,JIA C L,et al.Effect of the polymorphisms of keratin associated protein 8.2 gene on fibre traits in Inner Mongolia cashmere goats[J].Asian Australas J Anim Sci,2007,20(6):821-826.
[42]	MORGENTHALER C,DIRIBARNE M,CAPITAN A,et al.A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse[J].Genet Sel Evol,2017,49(1):85.
[43]	CADIEU E,NEFF M W,QUIGNON P,et al.Coat variation in the domestic dog is governed by variants in three genes[J]. Science,2009,326(5949):150-153.
[44]	KANG X L,LIU Y F,ZHANG J B,et al.Characteristics and expression profile of KRT71 screened by suppression subtractive hybridization cDNA library in curly fleece Chinese tan sheep[J].DNA Cell Biol,2017,36(7):552-564.
[45]	LIU Y F,KANG X L,YANG W J,et al.Differential expression of KRT83 regulated by the transcript factor CAP1 in Chinese Tan sheep[J].Gene,2017,614:15-20.
[46]	MU F,RONG E G,JING Y,et al.Structural characterization and association of ovine dickkopf-1 gene with wool production and quality traits in Chinese merino[J].Genes (Basel),2017,8(12):400.
[47]	LING Y H,XIANG H,ZHANG G,et al.Identification of complete linkage disequilibrium in the DSG4 gene and its association with wool length and crimp in Chinese indigenous sheep[J].Genet Mol Res,2014,13(3):5617-5625.
[48]	POŚPIECH E,CHEN Y,KUKLA-BARTOSZEK M,et al.Towards broadening forensic DNA phenotyping beyond pigmentation:improving the prediction of head hair shape from DNA[J].Forensic Sci Int Genet,2018,37:241-251.
[49]	LIU F,CHEN Y,ZHU G,et al.Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair[J].Hum Mol Genet,2018,27(3):559-575.
[50]	POŚPIECH E,KARŁOWSKA-PIK J,MARCIŚSKA M,et al.Evaluation of the predictive capacity of DNA variants associated with straight hair in Europeans[J].Forensic Sci Int Genet,2015,19:280-288.
[51]	RONG E G,YANG H,ZHANG Z W,et al.Association of methionine synthase gene polymorphisms with wool production and quality traits in Chinese Merino population[J].J Anim Sci,2015,93(10):4601-4609.
[52]	付雪峰,杨涵羽璐,石刚,等.不同羊毛纤维直径细毛羊皮肤组织差异表达蛋白质研究[J].中国畜牧兽医, 2016,43(4):879-891.FU X F,YANG H Y L,SHI G,et al.Proteome array on differentially expressed proteins of skin tissue in fine-wool sheep with different fiber diameter[J].China Animal Husbandry & Veterinary Medicine,2016,43(4):879-891.(in Chinese)
[53]	刘玉芳,康晓龙,方美英.滩羊FGF21基因CDS区克隆表达及生物信息学分析[J].中国畜牧杂志,2016,52(13):23-28.LIU Y F,KANG X L,FANG M Y.Cloning,expression,and bioinformatics analyses of the Tan sheep FGF21 gene cording region[J]. Chinese Journal of Animal Science,2016,52(13):23-28.(in Chinese)
[54]	杨佐青.滩羊皮肤组织差异蛋白质组学研究[D].银川:宁夏大学,2017.YANG Z Q.Study of differential proteomics of Tan sheep skin tissue[D].Yinchuan:Ningxia University,2017.(in Chinese)
[55]	于梦然.内蒙古绒山羊生长期和休止期皮肤蛋白质差异谱挖掘和验证[D].呼和浩特:内蒙古农业大学,2015.YU M R.Mining and verifying skin protein differentially expression profiles of Inner Mongolia cashmere goat during anagen and telogen[D]. Hohhot:Inner Mongolia Agricultural University,2015.(in Chinese)
[56]	LI Y,ZHOU G X,ZHANG R,et al.Comparative proteomic analyses using iTRAQ-labeling provides insights into fiber diversity in sheep and goats[J].J Proteomics,2018,172:82-88.
[57]	ZHAO J,LIU N,LIU K,et al.Identification of genes and proteins associated with anagen wool growth[J].Anim Genet,2017, 48(1):67-79.
[58]	FAN S M,TSAI C F,YEN C M,et al.Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin[J].Biomaterials,2018,167:121-131.

Research Progress on Biological Mechanisms Related to Wool Bending and Hair Follicle Development

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