白头翁素对腹泻小鼠肠黏膜修复因子EGFR和TGFβ1的影响

Abstract

Abstract:

Anemonin is the main component of pulsatilla, it has conspicuous control efficiency on diarrhoea. The aim of this study was to clarify the intestinal mucosa repair mechanism of anemonin on diarrhoea. The experiment established the diarrhoea model by porcine rotavirus (PRV) and E. coli, immunohistochemistry and RT-PCR were used in the study. The results showed that: In the preliminary stage of diarrhoea, the protein of TGFβ1 and EGFR in self-healing group, treatment group and prevention group were all higher than that of control group, and the prevention group was significantly higher than that of control group (P<0.05). The expression of EGFR mRNA and TGFβ1 mRNA in self-healing group, treatment group and prevention group were all significantly higher than that of control group (P<0.01). In the later stage of diarrhoea, the expression of EGFR and TGFβ1 gradually decreased until to the normal condition. The results suggeste that the mechanism of anemonin could significantly prevent diarrhoea caused by PRV and E. coli maybe has some relationships with regulating the expression of EGFR and TGFβ1.

CLC Number:

S853.74

LIU Ying, XU Qian-qian, XUE Xiao-yang, CHU Jun, XIAO Jing-jing, CHEN Li-gong, DONG Shi-shan. Effect of Anemonin on Intestinal Mucosa Repair Factors EGFR and TGFβ1 of Diarrheal Mice[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, doi: .

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References

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Effect of Anemonin on Intestinal Mucosa Repair Factors EGFR and TGFβ1 of Diarrheal Mice

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