吐鲁番黑羊体重和体尺性状全基因组关联分析

doi:10.11843/j.issn.0366-6964.2025.09.016

Abstract

Abstract:

This study aimed to identify candidate genes and molecular markers associated with body weight and body size traits in Turpan black sheep using genome-wide association study (GWAS), thereby providing a scientific basis for genetic breeding and resource development of Turpan black sheep. In this study, 129 healthy male Turpan black sheep aged 1 to 3 years, raised under the uniform conditions, were selected. Phenotypic data for 9 traits were measured: body weight, body height, body length, chest circumference, tube circumference, chest width, chest depth, tail width, and tail length. Peripheral blood samples (5 mL) were collected from the jugular vein using EDTA-K₂ anticoagulant vacuum tubes for DNA extraction. Qualified DNA samples underwent genotyping-by-sequencing (GBS). Raw sequencing data were processed, filtered, and annotated using software such as samtools and bcftools.Subsequently, population genetic structure analysis, population stratification assessment, and GWAS were performed using GCTA, TreeBeST, and GEMMA softwares, respectively. Sequencing yielded 160.88 G of raw data. After quality control, 157.87 G of clean data were obtained, identifying 460 766 SNP loci. GWAS detected 74 significant SNPs (P < 10^-5) associated with the 9 traits. Annotation revealed 39 candidate genes. Haplotype analysis showed that multiple significant SNPs were located within haplotype blocks. This study identified important genetic loci and candidate genes associated with body weight and body size traits of Turpan black sheep.The findings provide crucial insights for elucidating the genetic mechanisms underlying these traits and lay the foundation for molecular marker-assisted breeding in Turpan black sheep.

Key words: Turpan black sheep, body size traits, genome-wide association study, haplotype analysis

CLC Number:

S826.2

BAI Feng, MAERZIYA·Yasen , AMINIGULI·Abulaizi , TENG Wen, LUO Chunyan, NAZHAKAITI·Ainiwaner , ZHANG Yuntao, JI Xinmin, ZHANG Yanhua. Genome-Wide Association Study of Body Weight and Body Size Traits In Turpan Black Sheep[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(9): 4315-4327.

Figures/Tables 7

Table 1

Fig. 1

Fig. 2

Fig. 3

Table 2

SNPs and candidate genes significantly associated with body weight and body size traits"

性状 Trait	染色体 Chromosome	SNP位置 SNP location	基因型 Genotype	次等位基因频率 MAF	P值 P-value	功能注释 Functional annotation	候选基因 Candidate gene
体高 Body height	16	16:40065579	G/A	0.129 9	1.26×10^-6	intronic	ADAMTS12
体高 Body height	21	21:31871278	C/T	0.204 2	9.82×10^-7	intronic	OPCML
体长 Body length	14	14:60269030	G/T	0.068 0	2.86×10^-6	intronic	LOC101108416
	14	14:60269030	G/T	0.068 0	2.86×10^-6	intronic	LOC101112635
	18	18:63037938	G/A	0.264 0	3.49×10^-6	intronic	WDR25
	21	21:31871278	C/T	0.204 2	7.03×10^-6	intronic	OPCML
	24	24:24281700	G/A	0.472 9	3.48×10^-6	intronic	HS3ST4
体重 Body weight	1	1:162309133	A/G	0.238 3	3.55×10^-6	intronic	EPHA6
	3	3:6305883	C/T	0.267 7	2.67×10^-6	intronic	HMCN2
	3	3:209166910	T/C	0.101 6	7.67×10^-6	intergenic	C1RL
	7	7:60036524	C/G	0.075 6	6.42×10^-6	intronic	FBN1
	7	7:88861927	A/C	0.124 0	3.69×10^-6	intronic	NRXN3
	12	12:64948358	C/T	0.067 2	3.65×10^-6	intronic	C12H1orf21
	16	16:40065579	G/A	0.129 9	2.57×10^-6	intronic	ADAMTS12
	22	22:7206258	G/C	0.307 1	7.11×10^-6	intronic	PRKG1
	25	25:4258888	G/A	0.183 6	4.28×10^-6	intergenic	DISC1
	NW_024599828	NW_024599828: 1113906	A/C	0.359 5	1.88×10^-6	intronic	LOC101102275
	NW_024599828	NW_024599828: 1113906	A/C	0.359 5	1.88×10^-6	intronic	PAG3
胸围 Chest circumference	1	1:271185186	C/T	0.191 4	5.63×10^-6	intronic	KCNJ15
	3	3:203630569	C/T	0.230 5	7.19×10^-8	intronic	ETV6
	3	3:203630569	C/T	0.230 5	7.19×10^-8	intronic	LOC121819203
	6	6:86670534	T/A	0.475 8	7.88×10^-6	intergenic	LOC105612199
	16	16:40065579	G/A	0.129 9	1.15×10^-7	intronic	ADAMTS12
胸深 Chest depth	5	5:22169507	T/C	0.089 0	4.64×10^-7	intronic	MINAR2
	8	8:48325347	T/C	0.065 0	7.93×10^-6	UTR3	LOC101114365
	8	8:48325347	T/C	0.065 0	7.93×10^-6	UTR3	PM20D2
	10	10:82538718	T/C	0.119 8	3.26×10^-6	intronic	NALF1
胸宽 Chest width	19	19:19015339	A/G	0.101 6	8.97×10^-6	intronic	GRM7
	20	20:23813922	A/T	0.058 8	9.76×10^-6	intronic	PKHD1
	22	22:7206258	G/C	0.307 1	3.50×10^-6	intronic	PRKG1
尾长 Tail lenth	9	9:21983713	A/G	0.232 6	7.99×10^-6	intronic	KCNQ3
尾长 Tail lenth	20	20:22934892	G/A	0.346 2	3.20×10^-6	intergenic	TFAP2D
尾宽 Tail width	2	2:49086885	C/A	0.127 1	9.69×10^-6	intronic	ANKS6
	9	9:21983713	A/G	0.232 6	1.69×10^-6	intronic	KCNQ3
	14	14:6903044	T/C	0.259 7	3.28×10^-6	intronic	CDYL2
管围 Tube circumference	1	1:226721935	G/A	0.160 2	4.81×10^-6	intronic	LOC121818542
	1	1:226721935	G/A	0.160 2	4.81×10^-6	intronic	SPTSSB
	3	3:194022073	C/T	0.058 1	5.75×10^-6	intergenic	KCNJ8
	10	10:49503999	T/C	0.315 6	8.59×10^-6	intronic	KLF12

Table 2

Fig. 4

Fig. 5

References 47

1	关鸣轩, 种丽伟, 魏佩玲, 等. 吐鲁番黑羊肉品质分析[J]. 草食家畜, 2024 (5): 11- 17.
	GUAN M X , CHONG L W , WEI P L . Analysis on mutton quality of Turpan Black sheep[J]. Grass-Feeding Livestock, 2024 (5): 11- 17.
2	施海娜, 刘雨田, 李世恩, 等. 杜泊羊体质量与体尺指标的相关及回归分析[J]. 饲料研究, 2021, 44 (13): 5.
	SHI H N , LIU Y T , LI S E . Correlation and regression analyses of the body weight and body sizes in Dorper sheep[J]. Feed Research, 2021, 44 (13): 5.
3	海萨·艾也力汗, 张钰, 杨博文, 等. 基于简化基因组测序筛选白斑狗鱼耐热性状关联的InDel标记[J]. 水产学报, 2024, 48 (3): 039105.
	YELHAN HAISA , ZHANG Y , YANG B W , et al. Screening of InDel markers associated with heat tolerance traits in Esox lucius based on simplified genome sequencing[J]. Journal of Fisheries of China, 2024, 48 (3): 039105.
4	HAN M , WANG X , DU H , et al. Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat[J]. BMC Genomics, 2025, 26 (1): 37. doi: 10.1186/s12864-024-11097-1
5	XIANG X , PENG C , CAO D , et al. Whole genome sequencing reveals that five genes are related to BW trait in sheep[J]. Animal, 2024, 18 (9): 101282. doi: 10.1016/j.animal.2024.101282
6	LI Y , YANG H , GUO J , et al. Uncovering the candidate genes related to sheep body weight using multi-trait genome-wide association analysis[J]. Front Vet Sci, 2023, 10, 1206383. doi: 10.3389/fvets.2023.1206383
7	ZHANG F , LIU Q , GONG P , et al. Genome-wide association study provided insights into the polled phenotype and polled intersex syndrome (PIS) in goats[J]. BMC Genomics, 2024, 25 (1): 661. doi: 10.1186/s12864-024-10568-9
8	SELIONOVA M , AIBAZOV M , MAMONTOVA T , et al. Genome-wide association study of live body weight and body conformation traits in young Karachai goats[J]. Small Rumin Res, 2022, 216, 106836. doi: 10.1016/j.smallrumres.2022.106836
9	樊琛, 艾克拜尔·艾合麦提, 赵茜, 等. 己酮可可碱对吐鲁番黑羊新鲜精液生理活性的影响[J]. 中国畜牧杂志, 2024, 60 (9): 1- 11.
	FAN C , AKBAR AIHMET , ZHAO Q , et al. Effect of pentoxifylline on the physiological activity of fresh semen from Turpan Black Sheep[J]. Chinese Journal of Animal Science, 2024, 60 (9): 1- 11.
10	艾克拜尔·艾合麦提, 樊琛, 英提扎尔·阿不力孜, 等. 原花青素对吐鲁番黑羊精液低温保存效果的影响[J]. 中国畜牧杂志, 2024, 60 (01): 244- 248.
	AKBAR AIHMET , FAN C , INTIZAR ABLIZ , et al. Effect of proanthocyanidins on cryopreservation efficiency of Turpan Black sheep semen at low temperature[J]. Chinese Journal of Animal Science, 2024, 60 (9): 244- 248.
11	阿尔曼·海热, 艾克拜尔·艾合麦提, 古丽沙热·吾甫尔, 等. 不同季节吐鲁番黑羊血清中生殖激素的变化规律研究[J]. 中国畜牧杂志, 2024, 60 (1): 255- 259.
	ARMAN HAIRE , AKBAR AIHMET , GULSHAHERP WUPUR , et al. Study on the variation patterns of reproductive hormones in serum of Turpan Black Sheep in different seasons[J]. Chinese Journal of Animal Science, 2024, 60 (1): 255- 259.
12	HAIRE A , BAI J , ZHAO X , et al. Identifying the heat resistant genes by multi-tissue transcriptome sequencing analysis in Turpan Black sheep[J]. Theriogenology, 2022, 179, 78- 86. doi: 10.1016/j.theriogenology.2021.11.008
13	王琼, 曹行, 张小洪, 等. 新疆两个地方绵羊品种策勒黑羊、吐鲁番黑羊的基因组选择信号分析[J]. 草食家畜, 2021 (4): 1- 7.
	WANG Q , CAO H , ZHANG X H , et al. Signal analysis of genome-wide selection of two local sheep breeds in Xinjiang: Cele Black Sheep and Turpan Black Sheep[J]. Grass-Feeding Livestock, 2021 (4): 1- 7.
14	MA L . 301 Methods of genome-wide association studies and their applications in dairy cattle[J]. J Anim Sci, 2020, 98 (Supplement_4): 31.
15	REN J , GAO Z , LU Y , et al. Application of GWAS and mGWAS in livestock and poultry breeding[J]. Animals, 2024, 14 (16): 2382. doi: 10.3390/ani14162382
16	SATZ-JACOBOWITZ B , HUBMACHER D . The quest for substrates and binding partners: A critical barrier for understanding the role of ADAMTS proteases in musculoskeletal development and disease[J]. Dev Dyn, 2021, 250 (1): 8- 26. doi: 10.1002/dvdy.248
17	MOHAMEDI Y , FONTANIL T , CAL S , et al. ADAMTS-12: Functions and challenges for a complex metalloprotease[J]. Front Mol Biosci, 2021, 8, 686763. doi: 10.3389/fmolb.2021.686763
18	HOEFT K , KOCH L , ZIEGLER S , et al. ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts[J]. J Clin Invest, 2024, 134 (18): e170246. doi: 10.1172/JCI170246
19	JAIN B P , PANDEY S . WD40 repeat proteins: signalling scaffold with diverse functions[J]. Protein J, 2018, 37 (5): 391- 406. doi: 10.1007/s10930-018-9785-7
20	XU C , MIN J . Structure and function of WD40 domain proteins[J]. Protein Cell, 2011, 2 (3): 202- 214. doi: 10.1007/s13238-011-1018-1
21	ZHAO X , NIE C , ZHANG J , et al. Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study[J]. BMC Genomics, 2021, 22 (1): 610. doi: 10.1186/s12864-021-07755-3
22	SHIN S , HAN J Y , LEE K . Cloning of avian Delta-like 1 homolog gene: the biallelic expression of Delta-like 1 homolog in avian species[J]. Poult Sci, 2010, 89 (5): 948- 955. doi: 10.3382/ps.2009-00572
23	DEL CID J S , REED N I , MOLNAR K , et al. A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion[J]. J Biol Chem, 2019, 294 (48): 18232- 18243. doi: 10.1074/jbc.RA119.011109
24	LI L , HUANG J , LIU Y . The extracellular matrix glycoprotein fibrillin-1 in health and disease[J]. Front Cell Dev Biol, 2024, 11, 1302285. doi: 10.3389/fcell.2023.1302285
25	MUTHU M L , REINHARDT D P . Fibrillin-1 and fibrillin-1-derived asprosin in adipose tissue function and metabolic disorders[J]. J Cell Commun Signal, 2020, 14 (2): 159- 173. doi: 10.1007/s12079-020-00566-3
26	MUTHU M L , TIEDEMANN K , FRADETTE J , et al. Fibrillin-1 regulates white adipose tissue development, homeostasis, and function[J]. Matrix Biol, 2022, 110, 106- 128. doi: 10.1016/j.matbio.2022.05.002
27	SEDES L , WONDIMU E , CROCKETT B , et al. Fibrillin-1 deficiency in the outer perichondrium causes longitudinal bone overgrowth in mice with Marfan syndrome[J]. Hum Mol Genet, 2022, 31 (19): 3281- 3289. doi: 10.1093/hmg/ddac107
28	VANSCHOUWEN B , SELVARATNAM R , GIRI R , et al. Mechanism of camp partial agonism in protein kinase g (PKG)[J]. J Biol Chem, 2015, 290 (48): 28631- 28641. doi: 10.1074/jbc.M115.685305
29	TAWA P , ZHANG L , METWALLY E , et al. Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α[J]. J Biol Chem, 2022, 298 (9): 102284. doi: 10.1016/j.jbc.2022.102284
30	REN Y , CHEN X , ZHENG X , et al. Diverse WGBS profiles of longissimus dorsi muscle in Hainan black goats and hybrid goats[J]. BMC Genom Data, 2023, 24 (1): 77. doi: 10.1186/s12863-023-01182-x
31	SCHALL N , GARCIA J J , KALYANARAMAN H , et al. Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing[J]. JCI Insight, 2020, 5 (9): e135355. doi: 10.1172/jci.insight.135355
32	JAFARI A , SIERSBAEK M S , CHEN L , et al. Pharmacological inhibition of protein kinase g1 enhances bone formation by human skeletal stem cells through activation of rhoa-akt signaling[J]. Stem Cells, 2015, 33 (7): 2219- 2231. doi: 10.1002/stem.2013
33	庄兆辉, 仲永, 陈月婵, 等. Krüppel样因子在肌肉组织中的功能研究进展[J]. 遗传, 2018, 40 (9): 16.
	ZHUANG Z H , ZHONG Y , CHEN Y C , et al. Research progress on the roles of Krü ppel-like factors in muscle tissues[J]. Hereditas, 2018, 40 (9): 16.
34	ZAKERI S , AMINIAN H , SADEGHI S , et al. Krüppel-like factors in bone biology[J]. Cell Signal, 2022, 93, 110308. doi: 10.1016/j.cellsig.2022.110308
35	YANG J , LIU Z , LIU B , et al. Silencing of circCYP51A1 represses cell progression and glycolysis by regulating miR-490-3p/KLF12 axis in osteosarcoma under hypoxia[J]. J Bone Oncol, 2022, 37, 100455. doi: 10.1016/j.jbo.2022.100455
36	DU Y , WANG Y , LI Y , et al. miR-214-5p Regulating differentiation of intramuscular pre-adipocytes in goats via targeting KLF12[J]. Front Genet, 2021, 12, 748629. doi: 10.3389/fgene.2021.748629
37	ZAKI-DIZAJI M , ABAZARI M F , RAZZAGHI H , et al. GRM7 deficiency, from excitotoxicity and neuroinflammation to neurodegeneration: Systematic review of GRM7 deficient patients[J]. Brain Behavior Immun Health, 2024, 39, 100808. doi: 10.1016/j.bbih.2024.100808
38	EDMOND M A , HINOJO-PEREZ A , EFREM M , et al. Lipophilic compounds restore function to neurodevelopmental-associated KCNQ3 mutations[J]. Commun Biol, 2024, 7 (1): 1181. doi: 10.1038/s42003-024-06873-4
39	SHSNG T , CHEN X , XUE H , et al. The PKHD1 gene inhibits tumor proliferation and invasion in intrahepatic cholangiocarcinoma by activating the Notch pathway[J]. Int J Med Sci, 2024, 21 (14): 2655- 2663. doi: 10.7150/ijms.95964
40	LIU K , CHEN R , WANG X , et al. Biallelic ANKS6 null variants cause notable extrarenal phenotypes in a nephronophthisis patient and lead to hepatobiliary abnormalities by YAP1 deficiency[J]. Clin Genet, 2023, 104 (6): 625- 636. doi: 10.1111/cge.14412
41	ANDO K , TONG L , PENG D , et al. KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling[J]. Dev Cell, 2022, 57 (11): 1383- 1399.e7. doi: 10.1016/j.devcel.2022.04.019
42	SAMPER N , HAREARDÓTTIR L , DEPIERREUX D M , et al. Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development[J]. Front Immunol, 2024, 15, 1490250. doi: 10.3389/fimmu.2024.1490250
43	朱兰, 江炎庭, 欧阳依娜, 等. 云上黑山羊11号染色体单倍型构建及与产羔性状的关联性分析[J]. 中国畜牧杂志, 2024, 60 (2): 202-207+214.
	ZHU L , JIANG Y T , OUYANG Y N , et al. Construction of haplotype on chromosome 11 and association analysis with litter size traits in Yunshang Black Goat[J]. Chinese Journal of Animal Science, 2024, 60 (2): 202-207+214.
44	骆娜, 安炳星, 魏立民, 等. 全基因关联分析筛选文昌鸡体尺性状相关分子标记[J]. 中国农业科学, 2024, 57 (10): 2046- 2060.
	LUO N , AN B X , WEI L M , et al. Identification of molecular markers associated with body size traits through genome-wide association analysis in Wenchang Chickens[J]. Scientia Agricultura Sinica, 2024, 57 (10): 2046- 2060.
45	ARATA M , SUGIMURA K , UEMURA T . Difference in dachsous levels between migrating cells coordinates the direction of collective cell migration[J]. Dev Cell, 2017, 42 (5): 479- 497.e10. doi: 10.1016/j.devcel.2017.08.001
46	LE A P , RUPPRRECHT J F , MÈGE R M , et al. Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion[J]. Nat Commun, 2021, 12 (1): 397. doi: 10.1038/s41467-020-20563-9
47	HAYES A J , MELROSE J . Hs, an ancient molecular recognition and information storage glycosaminoglycan, equips hs-proteoglycans with diverse matrix and cell-interactive properties operative in tissue development and tissue function in health and disease[J]. Int J Mol Sci, 2023, 24 (2): 1148. doi: 10.3390/ijms24021148

性状 Trait	平均值 Mean value	标准差 Standard deviation	标准误 Standard error	最大值 Maximum value	最小值 Minimum value
体重/kg Body weight	56.70	15.28	1.35	87	37
体高/cm Body height	68.60	3.79	0.33	79	60
体斜长/cm Body lenth	70.81	3.90	0.34	84	62
胸宽/cm Chest width	21.19	9.09	0.80	79	15
胸深/cm Chest depth	29.27	3.14	0.28	36	21
胸围/cm Chest circumference	98.53	12.35	1.09	129	75
管围/cm Tube circumference	9.43	0.70	0.06	11.5	8
尾宽/cm Tail width	17.70	3.13	0.28	26	11
尾长/cm Tail lenth	13.88	3.04	0.27	20	5

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[15]	XU Pan，ZHANG Zhen，CUI Lei-lei，YANG Bin，DUAN Yan-yu. A Systems Genetics Study of Hematological Traits in a White Duroc × Erhualian Pigs F₂ Resource Population [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(2): 232-240.

Genome-Wide Association Study of Body Weight and Body Size Traits In Turpan Black Sheep

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