水杨酰苯胺类及咪唑并噻唑类抗寄生虫药物的理化性质及其应用研究进展

doi:10.11843/j.issn.0366-6964.2025.03.009

Abstract

Abstract:

Parasitic diseases significantly hinder the development of animal husbandry. The limited range of therapeutic drugs has led to severe drug resistance and suboptimal treatment outcomes. Consequently, there has been an increased demand for new drugs effective in preventing and treating parasitic diseases. In response, numerous clinical trials demonstrate that combining two or more antiparasitic drugs can enhance efficacy, broaden the antiparasitic spectrum, and mitigate parasite resistance. The combination of levamisole hydrochloride, an imidazole thiazole drug, and oxyclozanide, a salicylamide drug, has proven effective in treating nematode and schistosomiasis, with its unique mechanism of action garnering extensive researcher interest. This article provides a comprehensive review of the mechanisms of action, design and synthesis, physicochemical properties, research status, and therapeutic efficacy of these dual-class drug combinations.

Key words: parasites, salicylanilines, imidazolothiazoles, levamisole hydrochloride, oxyclozanide, efficacy

CLC Number:

S859.795

DAI Guonian, LI Bing, ZHOU Yaxin, LI Jiang, XU Jing, ZHOU Xuzheng, PENG Xiaoting, ZHANG Jiyu. Research Progress on The Physicochemical Properties and Applications of Salicylanilines and Imidazolothiazole Antiparasitic Drugs[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(3): 1065-1075.

Figures/Tables 6

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Research Progress on The Physicochemical Properties and Applications of Salicylanilines and Imidazolothiazole Antiparasitic Drugs

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