Abstract: The incidence of odontogenic tumors in dogs and cats is gradually increasing. The occurrence of odontogenic tumors is closely related to the development of teeth, and its diagnosis is difficult. To analyze the incidence and pathological manifestations of odontogenic tumors in dogs and cats from 2007 to 2022 by retrospective pathological methods, and to provide reliable basis for the pathological diagnosis of odontogenic tumors, and to provide meaningful guidance for clinical treatment and prognosis. A total of 371 samples or sections of dog and cat oral tumors were collected from several pet hospitals in China. The information of the cases was analyzed, HE staining was performed on typical cases to observe their characteristic pathological manifestations, and immunohistochemical staining for CK14 and vimentin were used to differentiate between odontogenic epithelial components and odontogenic extracellular matrix components, respectively. Among 371 samples or sections, 117 were odontogenic tumors, including 93 in dogs and 24 in cats. In dogs, the incidence of peripheral odontogenic fibroma is the highest, with males having a higher incidence than females. In cats, gingival hyperplasia is more common and there is no sex bias. Odontogenic tumors have a high incidence in dogs and cats, so the accurate diagnosis of these tumors deserves more attention. CK14 can be used as a good marker of odontogenic epithelium, which can help with accurate histopathological diagnosis and meaningful guidance for clinical treatment and prognosis judgment.

Key words: dog, cat, odontogenic tumors, pathological diagnosis