Acta Veterinaria et Zootechnica Sinica ›› 2022, Vol. 53 ›› Issue (7): 2094-2103.doi: 10.11843/j.issn.0366-6964.2022.07.007
• ANIMALGENETICS AND BREEDING • Previous Articles Next Articles
SHI Mingyue1, ZHANG Xuelian1, YANG Xiaofen2, NIU Jin1, XING Jiandong1, LU Chang1, GAO Pengfei1, GUO Xiaohong1, LI Bugao1, CAO Guoqing1*
Received:
2021-11-02
Online:
2022-07-23
Published:
2022-07-23
CLC Number:
SHI Mingyue, ZHANG Xuelian, YANG Xiaofen, NIU Jin, XING Jiandong, LU Chang, GAO Pengfei, GUO Xiaohong, LI Bugao, CAO Guoqing. Study on NR1H3 Gene Regulating Differentiation of Porcine Preadipocyte[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2094-2103.
[1] | TANG Q Q,LANE M D.Adipogenesis:from stem cell to adipocyte[J].Annu Rev Biochem,2012,81:715-736. |
[2] | FARMER S R.Transcriptional control of adipocyte formation[J].Cell Metab,2006,4(4):263-273. |
[3] | HERMAN M A,PERONI O D,VILLORIA J,et al.A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism[J]. Nature,2012,484(7394):333-338. |
[4] | HOFBAUER H F,SCHOPF F H,SCHLEIFER H,et al.Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids[J].Dev Cell,2014,29(6):729-739. |
[5] | WANG B,TONTONOZ P.Liver X receptors in lipid signalling and membrane homeostasis[J].Nat Rev Endocrinol,2018, 14(8):452-463. |
[6] | DALTON G D,OH S H,TANG L D,et al.Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice[J].iScience,2021,24(9):103089. |
[7] | SCHULMAN I G.Liver X receptors link lipid metabolism and inflammation[J].FEBS Lett,2017,591(19):2978-2991. |
[8] | BECARES N,GAGE M C,VOISIN M,et al.Impaired LXRα phosphorylation attenuates progression of fatty liver disease[J].Cell Rep,2019,26(4):984-995.e6. |
[9] | JALIL A,BOURGEOIS T,MÉNÉGAUT L,et al.Revisiting the role of LXRs in PUFA metabolism and phospholipid homeostasis[J]. Int J Mol Sci, 2019,20(15):3787. |
[10] | XIONG Y,XU Q,LIN S,et al.Knockdown of LXRα inhibits goat intramuscular preadipocyte differentiation[J].Int J Mol Sci,2018,19(10):3037. |
[11] | FAN Q,NØRGAARD R C,BINDESBØLL C,et al.LXRα regulates hepatic ChREBPα activity and lipogenesis upon glucose,but not fructose feeding in mice[J].Nutrients,2017,9(7):678. |
[12] | PAN Y X,ZHUO M Q,LI D D,et al.SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism in zebrafish Danio rerio[J].Chemosphere,2019,215:370-379. |
[13] | 曾德飞,李薇,汤琼健,等.肝X受体调节胆固醇代谢研究新进展[J].南通大学学报:医学版,2019,39(2):109-113.ZENG D F,LI W,TANG Q J,et al.Research progress of liver X receptor regulating cholesterol metabolism[J].Journal of Nantong University:Medical Science,2019,39(2):109-113.(in Chinese) |
[14] | REY M,KRUSE M S,MAGRINI-HUAMÁN R N,et al.High-fat diets and LXRs expression in rat liver and hypothalamus[J].Cell Mol Neurobiol,2019,39(7):963-974. |
[15] | ARCHER A,LAURENCIKIENE J,AHMED O,et al.Skeletal muscle as a target of LXR agonist after long-term treatment:focus on lipid homeostasis[J].Am J Physiol Endocrinol Metab,2014,306(5):E494-E502. |
[16] | 罗华伦,李万贵,张依裕,等.鸭LXRα基因过表达对原代肝细胞及PC3细胞脂质代谢的效应研究[J].畜牧兽医学报,2019,50(1):52-60.LUO H L,LI W G,ZHANG Y Y,et al.Effect of duck LXRα gene overexpression on lipid metabolism in primary hepatocytes and PC3 cells[J].Acta Veterinaria et Zootechnica Sinica,2019,50(1):52-60.(in Chinese) |
[17] | FILALI-MOUNCEF Y,HUNTER C,ROCCIO F,et al.The ménage à trois of autophagy,lipid droplets and liver disease[J].Autophagy,2022,18(1):50-72. |
[18] | RUIZ-OJEDA F J,RUPÉREZ A I,GOMEZ-LLORENTE C,et al.Cell models and their application for studying adipogenic differentiation in relation to obesity:a review[J].Int J Mol Sci,2016,17(7):1040. |
[19] | 张宁芳,成志敏,乐宝玉,等.猪肌源性前体脂肪细胞的分离培养和成脂诱导分化研究[J].畜牧兽医学报,2018,49(12):2612-2621.ZHANG N F,CHENG Z M,LE B Y,et al.Isolation,culture and adipogenic differention of pig myogenic preadipocytescell[J].Acta Veterinaria et Zootechnica Sinica,2018,49(12):2612-2621.(in Chinese) |
[20] | BOUGHANEM H,CABRERA-MULERO A,MILLÁN-GÓMEZ M,et al.Transcriptional analysis of FOXO1,C/EBP-α and PPAR-γ2 genes and their association with obesity-related insulin resistance[J].Genes (Basel),2019,10(9):706. |
[21] | MANUEL A M,WALLA M D,DORN M T,et al.Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte[J].Free Radic Biol Med,2020,148:70-82. |
[22] | RUSSO-SAVAGE L,SCHULMAN I G.Liver X receptors and liver physiology[J].Biochim Biophys Acta-Mol Basis Dis,2021,1867(6):166121. |
[23] | PEET D J,TURLEY S D,MA W Z,et al.Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα[J].Cell,1998,93(5):693-704. |
[24] | XU H F,LUO J,ZHANG X Y,et al.Activation of liver X receptor promotes fatty acid synthesis in goat mammary epithelial cells via modulation of SREBP1 expression[J].J Dairy Sci,2019,102(4):3544-3555. |
[25] | LASCH A,ALARCAN J,LAMPEN A,et al.Combinations of LXR and RXR agonists induce triglyceride accumulation in human HepaRG cells in a synergistic manner[J].Arch Toxicol,2020,94(4):1303-1320. |
[26] | CHEN Y Q,POTTANAT T G,ZHEN E Y,et al.ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition[J].J Lipid Res,2021,62:100068. |
[27] | GRINMAN D Y,CAREAGA V P,WELLBERG E A,et al.Liver X receptor-α activation enhances cholesterol secretion in lactating mammary epithelium[J].Am J Physiol Endocrinol Metab,2019,316(6):E1136-E1145. |
[28] | HU X Y,ZHANG N S,FU Y H.Role of liver X receptor in mastitis therapy and regulation of milk fat synthesis[J].J Mammary Gland Biol Neoplasia,2019,24(1):73-83. |
[29] | ZHANG Y Y,FAN X Y,QIU L H,et al.Liver X receptor α promotes milk fat synthesis in buffalo mammary epithelial cells by regulating the expression of FASN[J].J Dairy Sci,2021,104(12):12980-12993. |
[30] | JOSEPH S B,LAFFITTE B A,PATEL P H,et al.Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors[J].J Biol Chem,2002,277(13):11019-11025. |
[31] | RONG S X,CORTÉS V A,RASHID S,et al.Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice[J].eLife,2017,6:e25015. |
[32] | BENÍTEZ-SANTANA T,HUGO S E,SCHLEGEL A.Role of intestinal LXRα in regulating post-prandial lipid excursion and diet-Induced hypercholesterolemia and hepatic lipid accumulation[J].Front Physiol,2017,8:280. |
[33] | ZHANG Y X,GU Y Y,CHEN Y H,et al.Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD[J].J Ethnopharmacol,2021, 266:113436. |
[34] | DE QUEIROZ J C F,ALONSO-VALE M I C,CURI R,et al.Controle da adipogênese por ácidos graxos[J].Arq Bras Endocrinol Metabol,2009,53(5):582-594. |
[35] | NGUYEN T T P,KIM D Y,LEE Y G,et al.SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice[J].Mol Cell,2021,81(18):3820-3832.e7. |
[36] | 卢建雄,张国华,李昌辉,等.ChREBP基因siRNA表达质粒构建及对原代培养猪脂肪细胞生脂的影响[J].中国农业科学,2013,46(24):5196-5204.LU J X,ZHANG G H,LI C H,et al.Construction of siRNA expression plasmids targeting ChREBP gene and its effect on lipogenesis in primary cultured porcine adipocytes[J].Scientia Agricultura Sinica,2013,46(24):5196-5204.(in Chinese) |
[37] | IIZUKA K,TAKAO K,YABE D.ChREBP-Mediated regulation of lipid metabolism:involvement of the gut microbiota,liver,and adipose tissue[J].Front Endocrinol (Lausanne),2020,11:587189. |
[38] | ROSS S E,ERICKSON R L,GERIN I,et al.Microarray analyses during adipogenesis:understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism[J].Mol Cell Biol,2002,22(16):5989-5999. |
[39] | MATSUSHITA K,MORELLO F,ZHANG Z P,et al.Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling[J].Lab Invest,2016,96(2):230-238. |
[40] | ZHANG B,SHANG P,QIANGBA Y Z,et al.The association of NR1H3 gene with lipid deposition in the pig[J].Lipids Health Dis,2016,15:99. |
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