NAD+/SIRT2途径调节衰老卵母细胞成熟质量的分子机制

doi:10.11843/j.issn.0366-6964.2022.06.001

Abstract

Abstract: The maturation quality of oocytes not only is the basis of mammalian reproductive capacity, but also directly determines the quality of offspring. Premature ovarian failure usually causes a decline in the number and quality of oocytes, and how to improve its maturation quality has become a frontier topic in the field of reproductive aging. In recent years, the functions of nicotinamide adenine dinucleotide (NAD+) dependent deacetylase family Sirtuins (SIRT1-7) in reproductive aging have attracted increasing attention. Particularly, the acetylated substrates of the anti-aging factor SIRT2 are directly related to oocyte maturation events. This review focused on the recent research progress of NAD+/SIRT2 in improving the quality of aging oocytes through important physiological processes such as meiosis, energy metabolism, mitochondrial oxidative stress and mitochondrial quality control from a new perspective of acetylation regulating the aging and maturation of oocytes. It is expected to provide new ideas for improving the oocyte quality and prolonging the reproduction period in aged female livestock.

Key words: NAD+/SIRT2, oocyte, maturation quality, aging, mitochondria

CLC Number:

S814.1

XU Dejun, ZHAO Zhongquan, ZHAO Yongju. Molecular Mechanism of NAD+/SIRT2 Pathway Regulating Mature Quality of Aged Oocytes[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1657-1667.

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Molecular Mechanism of NAD+/SIRT2 Pathway Regulating Mature Quality of Aged Oocytes

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