杂交组合断奶仔猪腹泻与FUT1基因遗传变异的关联分析

doi:10.11843/j.issn.0366-6964.2021.03.005

Abstract

Abstract: The study aimed to explore the relationship between diarrhea of weaned piglets of hybrid combination and genetic variation of α-1,2-fucosyltransferase 1 (FUT1) gene. In this experiment, 35-day-old Dudian, Duzang and Duroc weaned piglets were selected as the research objects, and were divided into 3 groups according to breeds, with 113, 165 and 87 replicates, respectively. FUT1 gene polymorphism was detected by sequencing to analyze the correlation between gene polymorphism and diarrhea rate of weaned piglets. The results showed that there were 4 polymorphic sites in FUT1 gene, including T18C, C229T, C2418A and A306G, all of which were in moderate polymorphism and heterozygosity. C229T, C2418A and A306G were missense mutations, which might be key sites affecting porcine diarrhea. The degree of diarrhea was relatively serious in the hybrid combination Dudian, Duzang pig with TT genotype at T18C, and 3 pig populations with CC genotype at C229T, CA genotype at C2418A and GG genotype at A306G, which showed dominant inheritance. The result suggest that the effects of breeds and FUT1 gene polymorphisms on weaned piglets diarrhea have certain differences and correlations.

Key words: hybrid combination, FUT1 gene, genetic variation, weaned piglet, diarrhea, disease resistance breeding

CLC Number:

S828.2

FANG Chen, GUO Fei, HU Ruiju, YANG Minghua, ZHANG Bin, LIU Shaona, HUANG Ying, ZHAO Yanguang, ZHAO Sumei. Analysis of Correlation between Diarrhea and Genetic Variation of FUT1 Gene in Weaned Piglets of Hybrid Combination[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(3): 610-619.

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Analysis of Correlation between Diarrhea and Genetic Variation of FUT1 Gene in Weaned Piglets of Hybrid Combination

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