1例猫肾上腺皮质癌脾转移的病理及免疫组化分析

doi:10.11843/j.issn.0366-6964.2021.012.033

Abstract

Abstract: Metastasis of adrenal cortical carcinoma to the spleen in cats is very rare in veterinary clinical cases. In this report, a 10-year-old farm cat with abdominal pain, frequent vomiting, wasting, a history of chronic adrenal impairment, and splenomegaly on radiographic examination was described. Spleneectomy was performed on the cat and histopathological examination of the removed tissue was performed. Histopathological results showed that the tumor cells had abundant lipid-like vacuoles, large cell volume, and many mitotic images. The tumor cells had vascular invasion, and the nucleus was heavily stained. Immunohistochemical results showed positive expression of synaptophysin, S-100 and GATA4. Based on histopathology and immunohistochemistry, history and laboratory examination, the final diagnosis was splenic metastasis of adrenal cortical carcinoma. The clinical case and pathological diagnosis of splenic metastasis of adrenal cortical carcinoma in cats were reported for the first time, which has certain reference value for the clinical diagnosis and treatment of related diseases.

Key words: cat, adrenocortical carcinoma, histopathology, immunohistochemistry

CLC Number:

S857.4

DENG Zhaoyang, WANG Zheng, ZHANG Jiaren, HE Xijun, ZHENG Jiasan. Pathological and Immunohistochemical Analysis of Splenic Metastasis of Adrenal Cortical Carcinoma in a Cat[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(12): 3669-3674.

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Pathological and Immunohistochemical Analysis of Splenic Metastasis of Adrenal Cortical Carcinoma in a Cat

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