影响奶牛早期胚胎丢失的因素

doi:10.11843/j.issn.0366-6964.2020.05.002

Abstract

Abstract: Early embryo loss, that is, embryo death before implantation, is the leading factor determining the pregnancy rate in dairy cows. The high mortality of embryo before implantation in dairy cows brings tremendous economic losses to many farms. At present, it is generally recognized that early embryo loss is mainly related with chromosomal abnormalities, reproductive hormone disorders, heat stress, immune factors, twin pregnancy, diseases and vitamin B deficiency. The factors affecting early embryo loss are reviewed in order to provide a comprehensive reference for preventing early embryo loss in dairy cows.

Key words: early embryo loss, chromosomal abnormalities, hormones, heat stress, immunity, twin pregnancy, folic acid, vitamin B₁₂

CLC Number:

LUO Fang, ZHANG Meng, LI Yachao, CHEN Yonghong, TAO Jinzhong. Factors Associated with Early Embryo Loss in Dairy Cows[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(5): 907-913.

References 61

[1]	KOLTE A M,BERNARDI L A,CHRISTIANSEN O B,et al.Terminology for pregnancy loss prior to viability:a consensus statement from the ESHRE early pregnancy special interest group[J].Hum Reprod,2015,30(3):495-498.
[2]	HERLIHY M M,BERRY D P,CROWE M A,et al.Evaluation of protocols to synchronize estrus and ovulation in seasonal calving pasture-based dairy production systems[J].J Dairy Sci,2011,94(9):4488-4501.
[3]	DISKIN M G,MURPHY J J,SREENAN J M.Embryo survival in dairy cows managed under pastoral conditions[J].Anim Reprod Sci,2006,96(3-4):297-311.
[4]	WIJMA R,STANGAFERRO M L,KAMAT M M,et al.Embryo mortality around the period of maintenance of the corpus luteum causes alterations to the ovarian function of lactating dairy cows[J].Biol Reprod,2016,95(5):112.
[5]	DAILEY R A,INSKEEP E K,LEWIS P L.Pregnancy failures in cattle:a perspective on embryo loss[C]//Proceedings of the 18th International Conference on Reproduction of Farm Animals.Slovakia,2002:1-8.
[6]	SANTOS J E,THATCHER W W,CHEBEL R C,et al.The effect of embryonic death rates in cattle on the efficacy of estrus synchronization programs[J].Anim Reprod Sci,2004,82-83:513-535.
[7]	ROMERO S T,GEIERSBACH K B,PAXTON C N,et al.Differentiation of genetic abnormalities in early pregnancy loss[J]. Ultrasound Obstet Gynecol,2015,45(1):89-94.
[8]	崔恒宓.猪胚胎死亡原因(综述)[J].上海畜牧兽医通讯,1990(5):40-41.CUI H M.Causes of pig embryo death (review)[J].Shanghai Journal of Animal Husbandry and Veterinary Medicine, 1990(5):40-41.(in Chinese)
[9]	吴桂杰,马帅,郑连文,等.1例复杂染色体易位伴男性不育患者的家系核型分析及文献复习[J].北京大学学报:医学版, 2018,50(4):729-731.WU G J,MA S,ZHENG L W,et al.A complex chromosome translocation with male infertility of karyotype analysis and literature review[J].Journal of Peking University:Health Sciences,2018,50(4):729-731.(in Chinese)
[10]	GHOSH S,DAS P J,AVILA F,et al.A non-reciprocal autosomal translocation 64,XX,t(4;10) (q21;p15) in an arabian mare with repeated early embryonic loss[J].Reprod Domest Anim,2016,51(1):171-174.
[11]	DISKIN M G,WATERS S M,PARR M H,et al.Pregnancy losses in cattle:potential for improvement[J].Reprod Fertil Dev,2016,28(1-2):83-93.
[12]	王文忠.导致妊娠母牛胚胎早期死亡的三大原因[J].黑龙江动物繁殖,2016,24(2):34-35.WANG W Z.Three major causes of early death of pregnant cow embryos[J].Heilongjiang Journal of Animal Reproduction, 2016, 24(2):34-35.(in Chinese)
[13]	PUGET C,JOUEIDI Y,BAUVILLE E,et al.Serial HCG and progesterone levels to predict early pregnancy outcomes in pregnancies of uncertain viability:a prospective study[J].Eur J Obstet Gynecol Reprod Biol,2018,220:100-105.
[14]	FERGUSON C E,KESLER D J,GODKE R A.Improving pregnancy rates in problem breeder cattle by administration of 15 mg of progesterone on days 3-5 post-mating[J].J Appl Anim Res,2012,40(3):173-178.
[15]	FORDE N,CARTER F,FAIR T,et al.Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus development in cattle[J].Biol Reprod,2009,81(4):784-794.
[16]	ZHU Z,LI B B,WU Y,et al.Interferon-τ increases BOLA-I for implantation during early pregnancy in dairy cows[J]. Oncotarget, 2017,8(56):95095-95107.
[17]	GARCIA-ISPIERTO I,LÓPEZ-HELGUERA I,SERRANO-P ÉREZ B,et al.Progesterone supplementation during the time of pregnancy recognition after artificial insemination improves conception rates in high-producing dairy cows[J]. Theriogenology, 2016,85(7):1343-1347.
[18]	郭延生,陶金忠.基于LC-Q/TOF-MS代谢组学方法筛选奶牛妊娠识别阶段乳样生物标志物的研究[J].畜牧兽医学报, 2018,49(8):1633-1641.GUO Y S,TAO J Z.Selection of milk biomarkers of pregnancy recognition in dairy cows based on LC-Q/TOF-MS metabolomics[J]. Acta Veterinaria et Zootechnica Sinica,2018,49(8):1633-1641.(in Chinese)
[19]	程蕾,王定发,刘晓华,等.ISG15和OAS1在奶牛早期妊娠阶段外周血中的表达规律[J].畜牧兽医学报,2015,46(1):77-84.CHENG L,WANG D F,LIU X H,et al.Study on ISG15 and OAS1 transcriptions in peripheral blood of dairy cows during early pregnancy[J].Acta Veterinaria et Zootechnica Sinica,2015,46(1):77-84.(in Chinese)
[20]	李瑞婷,靳方圆,杨洪娟,等.干扰素-τ在反刍动物早期妊娠胚胎着床过程中的研究进展[J].黑龙江畜牧兽医,2016(5):87-89.LI R T,JIN F Y,YANG H J,et al.Research progress of interferon-τ in early pregnancy embryo implantation of ruminants[J]. Heilongjiang Animal Science and Veterinary Medicine,2016(5):87-89.(in Chinese)
[21]	张明,郑洁,甘潇,等.孕酮、干扰素τ对牛子宫内膜上细胞外基质及其相关配体表达的影响[J].畜牧兽医学报, 2013, 44(2):309-315.ZHANG M,ZHENG J,GAN X,et al.Effects of progesterone,interferon-τ on expression of the related genes of extracellular matrix-their ligands in cultured bovine endometrial cells[J].Acta Veterinaria et Zootechnica Sinica,2013,44(2):309-315.(in Chinese)
[22]	杨宏振.中国荷斯坦奶牛产后子宫复原及早期胚胎发育规律研究[D].武汉:华中农业大学,2012.YANG H Z.Study on uterine involution in postpartum and early embryo development on Chinese Holstein dairy cows[D]. Wuhan:Huazhong Agricultural University,2012.(in Chinese)
[23]	ROBINSON R S,HAMMOND A J,WATHES D C,et al.Corpus luteum-endometrium-embryo interactions in the dairy cow:underlying mechanisms and clinical relevance[J].Reprod Domest Anim,2008,43(S2):104-112.
[24]	KING G J,ATKINSON B A,ROBERTSON H A.Development of the bovine placentome from days 20 to 29 of gestation[J].J Reprod Fertil, 1980,59(1):95-100.
[25]	王潇.孕酮、雌二醇调控奶牛滋养层细胞表达IFN-τ的研究[D].武汉:华中农业大学,2012.WANG X.Regulation of IFN-τ expression in bovine trophoblast cell by progesterone and estradiol[D].Wuhan:Huazhong Agricultural University,2012.(in Chinese)
[26]	FERGUSON C E,KESLER D J,GODKE R A.Progesterone enhances in vitro development of bovine embryos[J]. Theriogenology, 2012,77(1):108-114.
[27]	谢红霞.奶牛早期胚胎死亡的原因及防治措施[J].现代畜牧科技,2016(5):94.XIE H X.Causes and prevention measures of early embryo death in dairy cows[J].Modern Animal Husbandry Science & Technology,2016(5):94.(in Chinese)
[28]	王根林,沈家森,曹军.黄体酮在奶牛繁殖上的应用[J].中国奶牛,1990(4):39-40.WANG G L,SHEN J S,CAO J.Application of progesterone in dairy cow breeding[J].China Dairy Cattle,1990(4):39-40.(in Chinese)
[29]	CARVALHO P D,SANTOS V G,FRICKE H P,et al.Effect of manipulating progesterone before timed artificial insemination on reproductive and endocrine outcomes in high-producing multiparous Holstein cows[J].J Dairy Sci,2019,102(8):7509-7521.
[30]	CLEMENTE M,DE LA FUENTE J,FAIR T,et al.Progesterone and conceptus elongation in cattle:a direct effect on the embryo or an indirect effect via the endometrium?[J].Reproduction,2009,138(3):507-517.
[31]	LÓPEZ-GATIUS F,SANTOLARIA P,YÁNIZ J L,et al.Progesterone supplementation during the early fetal period reduces pregnancy loss in high-yielding dairy cattle[J].Theriogenology,2004,62(8):1529-1535.
[32]	GARCÍA-ISPIERTO I,LÓPEZ-GATIUS F,SANTOLARIA P,et al.Relationship between heat stress during the peri-implantation period and early fetal loss in dairy cattle[J].Theriogenology,2006,65(4):799-807.
[33]	LÓPEZ-GATIUS F,SANTOLARIA P,YÁNIZ J,et al.Factors affecting pregnancy loss from gestation day 38 to 90 in lactating dairy cows from a single herd[J].Theriogenology,2002,57(4):1251-1261.
[34]	LIU Y Q,SHEN Y,ZHANG H,et al.Clinical outcomes of multifetal pregnancy reduction in trichorionic and dichorionic triplet pregnancies:a retrospective observational study[J].Taiwan J Obstet Gynecol,2019,58(1):133-138.
[35]	MUR-NOVALES R,LOPEZ-GATIUS F,FRICKE P M,et al.An economic evaluation of management strategies to mitigate the negative effect of twinning in dairy herds[J].J Dairy Sci,2018,101(9):8335-8349.
[36]	LÓPEZ-GATIUS F.The effect on pregnancy rate of progesterone administration after manual reduction of twin embryos in dairy cattle[J].J Vet Med A Physiol Pathol Clin Med,2005,52(4):199-201.
[37]	OTT T L.Symposium review:immunological detection of the bovine conceptus during early pregnancy[J].J Dairy Sci, 2019, 102(4):3766-3777.
[38]	KWAK-KIM J, BAO S,LEE S K,et al.Immunological modes of pregnancy loss:inflammation,immune effectors,and stress[J].Am J Reprod Immunol,2014,72(2):129-140.
[39]	GAZZINELLI R T,OSWALD I P,HIENY S,et al.The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent,nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β[J].Eur J Immunol,1992,22(10):2501-2506.
[40]	DAHL M O,DE VRIES A,MAUNSELL F P,et al.Epidemiologic and economic analyses of pregnancy loss attributable to mastitis in primiparous Holstein cows[J].J Dairy Sci,2018,101(11):10142-10150.
[41]	ROMANO J E,THOMPSON J A,KRAEMER D C,et al.Early pregnancy diagnosis by palpation per rectum:influence on embryo/fetal viability in dairy cattle[J].Theriogenology,2007,67(3):486-493.
[42]	李小杉,杨丰利.奶牛肢蹄病对繁殖性能的影响[J].中国畜牧兽医,2014,41(5):248-251.LI X S,YANG F L.Effect of lameness on reproductive performance in dairy cows[J].China Animal Husbandry & Veterinary Medicine,2014,41(5):248-251.(in Chinese)
[43]	MELENDEZ P,BARTOLOME J,ARCHBALD L F,et al.The association between lameness,ovarian cysts and fertility in lactating dairy cows[J].Theriogenology,2003,59(3-4):927-937.
[44]	OLECHNOWICZ J,JAŚKOWSKI J M.Relation between clinical lameness and reproductive performance in dairy cows[J]. Medycyna Wet,2011,67(1):5-9.
[45]	GILBERT R O,SHIN S T,GUARD C L,et al.Prevalence of endometritis and its effects on reproductive performance of dairy cows[J]. Theriogenology,2005,64(9):1879-1888.
[46]	PAUL C.Folic acid in pregnancy[J].BJOG,2016,123(3):392.
[47]	DUPLESSIS M,LAPIERRE H,OUATTARA B,et al.Whole-body propionate and glucose metabolism of multiparous dairy cows receiving folic acid and vitamin B12 supplements[J].J Dairy Sci,2017,100(10):8578-8589.
[48]	LIKIS F.Folic acid[J].J Midwifery Womens Health,2016,61(6):797-798.
[49]	DUPLESSIS M,LAPIERRE H,PELLERIN D,et al.Effects of intramuscular injections of folic acid,vitamin B12,or both,on lactational performance and energy status of multiparous dairy cows[J].J Dairy Sci,2017,100(5):4051-4064.
[50]	SERVY E J,JACQUESSON-FOURNOLS L,COHEN M,et al.MTHFR isoform carriers.5-MTHF (5-methyl tetrahydrofolate) vs folic acid:a key to pregnancy outcome:a case series[J].J Assist Reprod Genet,2018,35(8):1431-1435.
[51]	HWANG K R,CHOI Y M,KIM J J,et al.Methylenetetrahydrofolate reductase polymorphisms and risk of recurrent pregnancy loss:a case-control study[J].J Korean Med Sci,2017,32(12):2029-2034.
[52]	GULATI S.Association of serum homocysteine,vitamin B12 and folic acid levels with metabolic syndrome[J].J Assoc Physicians India,2018,66(7):101-102.
[53]	LAANPERE M,ALTMÄE S,STAVREUS-EVERS A,et al.Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability[J].Nutr Rev,2010,68(2):99-113.
[54]	FURNESS D,FENECH M,DEKKER G,et al.Folate,vitamin B12,vitamin B6 and homocysteine:impact on pregnancy outcome[J]. Mater Child Nutr,2013,9(2):155-166.
[55]	SHAHINE L,LATHI R.Recurrent pregnancy loss:evaluation and treatment[J].Obstet Gynecol Clin North Am,2015, 42(1):117-134.
[56]	WANG L,CHANG S Y,WANG Z,et al.Altered GNAS imprinting due to folic acid deficiency contributes to poor embryo development and may lead to neural tube defects[J].Oncotarget,2017,8(67):110797-110810.
[57]	LI H Q,LIU Q,WANG C,et al.Effects of dietary supplements of rumen-protected folic acid on lactation performance,energy balance,blood parameters and reproductive performance in dairy cows[J].Anim Feed Sci Technol,2016,213:55-63.
[58]	GAGNON A,KHAN D R,SIRARD M A,et al.Effects of intramuscular administration of folic acid and vitamin B12 on granulosa cells gene expression in postpartum dairy cows[J].J Dairy Sci,2015,98(11):7797-7809.
[59]	DUPLESSIS M,GIRARD C L,SANTSCHI D E,et al.An economic model evaluating the supplementation of folic acid and vitamin B12 given around parturition and in early lactation on dairy farms in Québec,Canada[J].Can J Anim Sci,2014, 94(4):737-747.
[60]	XU Y J,LI Y,TANG Y,et al.The maternal combined supplementation of folic acid and Vitamin B12 suppresses ethanol-induced developmental toxicity in mouse fetuses[J].Reprod Toxicol,2006,22(1):56-61.
[61]	SANTOLARIA P,LÓPEZ-GATIUS F,GARCÁA-ISPIERTO I,et al.Effects of cumulative stressful and acute variation episodes of farm climate conditions on late embryo/early fetal loss in high producing dairy cows[J].Int J Biometeorol,2010,54(1):93-98.

Factors Associated with Early Embryo Loss in Dairy Cows

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 61

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	HAN Fuzhen, CAI Limeng, LI Zhuoran, WANG Xueying, XIE Weichun, KUANG Hongdi, LI Jiaxuan, CUI Wen, JIANG Yanping, LI Yijing, SHAN Zhifu, TANG Lijie. Research Progress on the Mechanism of Intestinal Flora-Mediated Regulation of Intestinal Mucosal Immunity by Secondary Bile Acids and Their Receptors [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(5): 1904-1913.
[2]	ZHANG Jixian, FAN Dingkun, FU Yuze, JIAO Shuai, MA Tao, BI Yanliang, ZHANG Naifeng. Research Progress on Mechanism and Application of Postbiotics in Regulating Animal Intestinal Health [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(5): 1926-1935.
[3]	LIU Sidi, MA Ben, ZHENG Yan, QIU Yunqiao, YAO Zelong, CAO Zhongzan, LUAN Xinhong. Research Progress in the Regulation of Intestinal Flora on Intestinal Mucosal Immunity and Inflammation in Animals [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1423-1431.
[4]	WANG Xiao, ZHANG Hao, LUAN Qingjiang, LI Hui, YANG Ding, WANG Tingyue, TIAN Jing, ZHAO Meng, CHEN Lu, TIAN Rugang. A Comprehensive Review of the Impact of Cold and Heat Stress on the Physiological Parameters and Gene Expression in Beef Cattle [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 894-904.
[5]	HUO Yuannan, QIU Meijia, ZHANG Jiaojiao, YANG Weirong, WANG Xianzhong. Arginine and Its Metabolites Attenuate Heat Stress-induced Apoptosis of Immature Boar Sertoli Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(2): 587-597.
[6]	XIAO Yimei, WANG Shengnan, XU Yuewen, HE Xiaolin, YIN Fuquan. Research on the Influence of Heat Stress on Male Reproduction [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 11-21.
[7]	ZHANG Hang, YANG Baigao, XU Xi, FENG Xiaoyi, DU Weihua, HAO Haisheng, ZHU Huabin, ZHANG Peipei, ZHAO Xueming. Research Progress on the Mechanism of Heat Stress Affecting the Development of Dairy Cow Embryos [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2692-2700.
[8]	ZHAO Wanli, CAO Qiqi, YANG Yue, DENG Zhaoju, XU Chuang. The Interaction between Gastrointestinal Microbiota and Mucosal Immunity in Health of Perinatal Dairy Cows [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2751-2760.
[9]	WANG Zixuan, WANG Qiao, ZHANG Jin, Astrid Lissette Barreto Sánchez, ZHENG Maiqing, LI Qinghe, CUI Huanxian, AN Bingxing, ZHAO Guiping, WEN Jie, LI Hegang. Transcriptome Based Screening of Functional Genes Related to Heat Stress Resistance in Beijing You Chickens and Guangming Broilers [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1905-1914.
[10]	LI Yicong, PU Feiyang, FENG Xili, WANG Mengzhu, ZHAO Zeyang, ZHANG Derong, MA Zhongren, ZHOU Jianhua. Research Progress on Immunological Characteristics of Bovine Viral Diarrhea Virus Protein and Vaccines [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1381-1391.
[11]	FENG Xiaoyi, YANG Baigao, HAO Haisheng, DU Weihua, ZHU Huabin, CUI Kai, ZHAO Xueming. Mechanism and Solution of Heat Stress Induced Embryo Quality Decline in Dairy Cows [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 868-876.
[12]	YUAN Yancong, HE Hang, LIU Anfang, WAN Kun, ZHANG Jie. Comparative Analysis of Digestive Physiology, Immunity and Gut Microbiota of Sichuan White Goose with Different Body Weight [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 1124-1134.
[13]	LIU Huijuan, WANG Chao, ZHOU Binbin, ZHANG Jiaqi, WANG Tian, ZHUANG Su. Effects of Dietary Rutin Supplementation on Ileal Morphology, Immunity, Antioxidant and Barrier Function of Broilers [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 630-641.
[14]	XUE Hongyan, YANG Mengyu, YANG Huan, DONG Lijun, CAI Xiaqing, ZHAO Zemin, WANG Xianzhong. The Role of ALOX15B-JNK in Heat Stress-induced Oxidative Stress and Apoptosis of Sertoli Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5056-5065.
[15]	FAN Jinquan, ZHANG Yuhang, TANG Wuyang, ZHAO Xinyu, LI Pishun, ZHENG Xiaofeng. Inhibitory Effect of Decitabine on Porcine Circovirus Type 2 in vitro [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5134-5142.