哺乳动物原始卵泡形成与发育的研究进展

doi:10.11843/j.issn.0366-6964.2020.03.002

Abstract

Abstract: In most female mammals, the migration of primordial germ cells, germ cells meiosis, and breakdown of germ cell nests are regarded as the 3 critical processes for the formation of early primordial follicles. In addition, there are some special factors and signaling pathways regulating the formation and development of primordial follicles. However, the reproductive ability of a female is determined by the size and reserve capacity of her primordial follicle pool. This review summarizes the factors and signaling pathways involved in the formation and development of primordial follicles, with the aim of understanding the cellular and molecular mechanisms and providing research ideas for maintaining the primordial follicle pool and promoting primordial follicle activation.

Key words: mammal, ovary, primordial follicle, formation and development, signaling pathway

CLC Number:

S821.3

YANG Meixia, ZHANG Yufang, TANG Yaru, ZHANG Hongliang, WANG Shuilian. Research Progresses on the Formation and Development of Primordial Follicles in Mammals[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(3): 417-425.

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Research Progresses on the Formation and Development of Primordial Follicles in Mammals

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