FBXL家族在哺乳动物生物节律中调控作用的研究进展

doi:10.11843/j.issn.0366-6964.2020.02.002

Abstract

Abstract: The F-box and leucine rich repeat protein 3 (FBXL3) gene encodes the protein containing the F-box domain. It belongs to the F-box protein family and plays a role in the nucleus.The F-box and leucine rich repeat protein 21 (FBXL21) is located in the cytoplasm, and its function is antagonistic to the function of FBXL3 gene. FBXL3 and FBXL21 proteins both play important roles in the negative feedback cycle of molecular circadian rhythm in mammals. FBXL3 participates in the regulation of biological clock by forming SCF complex, which exercise E3 ubiquitin ligase function and promote the degradation of CRY protein through ubiquitination. FBXL21 makes CRY protein accumulation to participate in biological clock regulation through ubiquitination. The antagonism of FBXL3 and FBXL21 to CRY protein can stabilize the biological clock of mammals. In this review, the biological rhythm and the elements of biological clock were introduced firstly. Then, the regulation mechanism of FBXL family in circadian rhythm and the effects of FBXL family mutation on seasonal estrus traits in sheep were reviewed. It is helpful to explore the molecular mechanism of FBXL family mutation affecting sheep seasonal estrus deeply, and provide new ideas for changing sheep estrous season using modern biotechnology.

Key words: biological rhythm, FBXL3 gene, FBXL21 gene, seasonal estrus, molecular mechanism, sheep

CLC Number:

S852.2

ZHONG Yingjie, XIANG Guangming, DI Ran, HU Wenping, WANG Xiangyu, CHU Mingxing, LIU Qiuyue. Advances in the Regulation of FBXL Family in Mammalian Biorhythms[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(2): 217-226.

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Advances in the Regulation of FBXL Family in Mammalian Biorhythms

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