儿茶素类物质调控动物肠道屏障功能的机制研究及应用进展

doi:10.11843/j.issn.0366-6964.2025.12.007

摘要/Abstract

摘要：

儿茶素类物质是一种从植物中提取的酚类活性物质，因其显著的抗氧化、抗炎、抗菌与抗肿瘤等生物特性，在保护肠道健康与稳态方面表现出优异特性，而稳定、健康的肠道环境是维持动物体的生长发育与机体健康的关键性因素。近年来，国内外的大量临床研究报道了儿茶素类物质缓解肠道损伤的作用机制，包括调节细胞间隙连接、激发炎症与氧化应激相关通路调节免疫功能以及调节肠道菌群的平衡等方面稳定肠道稳态，但在动物实际生产中的应用鲜有报道。本文综述了儿茶素类物质的生物学特性、修复肠道屏障的效果与机制，并展望儿茶素类物质于动物生产中应用的研究进展，为儿茶素类物质在养殖业中的合理利用提供参考。

关键词: 儿茶素类物质, 肠道屏障, 免疫功能, 动物生产

Abstract:

Catechins are phenolic active substances extracted from plants. Because of their significant antioxidant, anti-inflammatory, antibacterial and anti-tumor biological properties, they perform excellent in protecting intestinal health and homeostasis. A stable and healthy intestinal environment is crucial for the growth, development, and overall health of animals. In recent years, a large number of clinical studies at home and abroad have reported the mechanism of catechins in alleviating intestinal injury, including regulating intercellular tight junctions, stimulating inflammation and oxidative stress-related pathways to regulate immune function, and regulating the balance of intestinal flora to stabilize intestinal homeostasis. However, there are few reports on the application of catechins in animal production. This paper reviews the biological characteristics of catechins, the effect and mechanism of repairing intestinal barrier, and looks forward to the research progress of the application of catechins in animal production, so as to provide reference for the rational use of catechins in livestock farming.

Key words: catechins, intestinal barrier, immune function, animal production

中图分类号:

S816.7

赵雨薇, 王卓, 张城瑞, 屠焰, 刁其玉, 崔凯. 儿茶素类物质调控动物肠道屏障功能的机制研究及应用进展[J]. 畜牧兽医学报, 2025, 56(12): 6013-6024.

ZHAO Yuwei, WANG Zhuo, ZHANG Chengrui, TU Yan, DIAO Qiyu, CUI Kai. Mechanism Research and Application Progress of Catechins Regulating Animal Intestinal Barrier Function[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(12): 6013-6024.

图/表 3

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名称 Name	分子式 Molecular formula	羟基数 Hydroxyl groups	化学结构 Chemical structure
儿茶素(+)-Catechin	C₁₅H₁₄O₆	2
没食子儿茶素(+)-Gallocatechin	C₁₅H₁₄O₇	3
表儿茶素(-)-Epicatechin	C₁₅H₁₄O₆	2
表没食子儿茶素(-)-Epigallocatechin	C₁₅H₁₄O₇	3
表没食子儿茶素没食子酸酯 (-)-Epigallocatechin gallate	C₂₂H₁₈O₁₁	3
表儿茶素没食子酸酯 (-)-Epicatechin gallate	C₂₂H₁₈O₁₀	2
没食子儿茶素没食子酸酯 (-)-Gallocatechin gallate	C₂₂H₁₈O₁₁	3
儿茶素没食子酸酯 (-)-Catechin gallate	C₂₂H₁₈O₁₀	2

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