植物源性黄酮类化合物介导微生物保护肠道屏障的机制

doi:10.11843/j.issn.0366-6964.2025.12.006

摘要/Abstract

摘要： 黄酮类化合物是源自天然植物的一类活性成分，具有抗氧化、抗炎、降低氧化应激、改善肠道菌群结构、保护肠黏膜、调节免疫和促进生长等药理效果。本文系统性地综述了黄酮类化合物在动物肠道健康及屏障保护中的作用，简述了其独特的物理化学特性，归纳了其在生物体内的消化、吸收及代谢途径，重点阐述了黄酮类化合物与肠道微生物的互作效应，深入剖析了黄酮类物质可通过介导肠道微生物区系，产生短链脂肪酸、胆汁酸及其受体和色氨酸等关键代谢产物来影响肠道屏障的生理功能。旨在为植物源黄酮类化合物在动物饲养与生产实践中的开发利用，尤其是幼龄动物肠道健康的研究中奠定坚实的理论基础。

关键词: 黄酮类化合物, 肠道屏障, 肠道微生物区系, 短链脂肪酸, 胆汁酸, 色氨酸

Abstract: Flavonoids are a class of active ingredients derived from natural plants, which has excellent pharmacological effects such as antiox idant, anti-inflammatory, reducing oxidative stress, improving the structure of intestinal flora, protecting intestinal mucosa, regulating immunity and promoting growth. This paper provides a systematic review of the role of flavonoids in animal intestinal health and barrier protection, briefly describes their unique physicochemical properties, summarises their digestive, absorptive and metabolic pathways in living organisms, focuses on the interactions between flavonoids and gut microorganisms, and provides insight into how flavonoids can influence the physiological function of the intestinal barrier by mediating the intestinal microbiota and generating key metabolites, such as short-chain fatty acids, bile acids and their receptors and tryptophan and other key metabolites to influence the physiological function of the intestinal barrier. The aim is to lay a solid theoretical foundation for the development and utilization of plant-derived flavonoids in animal feeding and production practices, especially in the study of intestinal health in young animals.

Key words: flavonoids, intestinal barrier, gut microflora, short-chain fatty acids, bile acids, tryptophan

中图分类号:

S816

王雨珊, 刘旺景. 植物源性黄酮类化合物介导微生物保护肠道屏障的机制[J]. 畜牧兽医学报, 2025, 56(12): 5998-6012.

WANG Yushan, LIU Wangjing. Mechanisms of Plant-derived Flavonoids Mediating Microbial Protection of the Intestinal Barrier[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(12): 5998-6012.

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