T-2毒素对雄性动物生殖系统毒害机制的研究进展

doi:10.11843/j.issn.0366-6964.2025.05.005

畜牧兽医学报 ›› 2025, Vol. 56 ›› Issue (5): 2038-2046.doi: 10.11843/j.issn.0366-6964.2025.05.005

T-2毒素对雄性动物生殖系统毒害机制的研究进展

陈云¹(), 陈丽圆¹, 宋文静², 张新科², 徐菡¹, 吴嘉仪¹, 赵翠燕¹^,*(), 张守全²^,*()

1. 韶关学院生物与农业学院/广东省粤北食药资源利用与保护重点实验室，韶关 512005
2. 华南农业大学动物科学学院/广东省农业动物基因组学与分子育种重点实验室，广州 510642

收稿日期:2024-10-24 出版日期:2025-05-23 发布日期:2025-05-27
通讯作者: 赵翠燕,张守全 E-mail:luxixiworld@163.com;bethzhao2003@163.com;sqzhang@scau.com
作者简介:陈云(1986-)，女，山东成武人，讲师，博士，主要从事动物遗传育种与繁殖研究，E-mail：luxixiworld@163.com
基金资助:
国家自然科学基金(32272873)；广东省基础与应用基础研究基金项目(2023A1515010232)；广东省普通高校特色创新项目(2024KTSCX068)；2024年度韶关市支持科研工作者项目(P0000876050)

Research Progress on the Mechanism of T-2 Toxin 's Impact on Male Animal Reproduction

CHEN Yun¹(), CHEN Liyuan¹, SONG Wenjing², ZHANG Xinke², XU Han¹, WU Jiayi¹, ZHAO Cuiyan¹^,*(), ZHANG Shouquan²^,*()

1. Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China
2. Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China

Received:2024-10-24 Online:2025-05-23 Published:2025-05-27
Contact: ZHAO Cuiyan, ZHANG Shouquan E-mail:luxixiworld@163.com;bethzhao2003@163.com;sqzhang@scau.com

摘要/Abstract

摘要：

T-2毒素是一种广泛存在于谷物和饲料中的霉菌毒素，对人类和动物的健康构成严重威胁。本文旨在全面总结T-2毒素的来源、理化性质及其对雄性生殖系统的毒性作用，尤其是其在生殖过程中的机制与影响。本文回顾了T-2毒素通过氧化应激、线粒体损伤、细胞凋亡等途径对睾丸、精子质量及生殖内分泌系统的损害，还探讨了T-2毒素暴露对雄性动物睾丸间质细胞、支持细胞及精子生成的影响，并总结了抗氧化物质及天然解毒剂在减轻T-2毒素引起的生殖障碍中的潜在应用。通过分析T-2毒素的毒性机制，本文为未来研究提供了指导，为制定有效的防治策略和开发解毒药物提供科学依据，进而保障畜禽生殖健康及畜牧业的可持续发展。

关键词: T-2毒素, 雄性动物生殖, 氧化应激, 炎症, 细胞凋亡

Abstract:

T-2 toxin is a mycotoxin widely found in grains and animal feed, posing a significant threat to human and animal health. The review aims to provide a comprehensive summary of the sources, physicochemical properties, and reproductive toxicity of T-2 toxin, with a particular focus on its mechanisms and effects on male reproductive systems. The review explores the toxicological pathways of T-2 toxin, including oxidative stress, mitochondrial damage, and cell apoptosis, and their impact on testicular function, sperm quality, and endocrine regulation of reproduction. Additionally, the review discusses the effects of T-2 toxin exposure on leydig cells, sertoli cells, and spermatogenesis, as well as examines the potential application of antioxidants and natural detoxifying agents in alleviating reproductive dysfunction induced by T-2 toxin. By analyzing the toxicity mechanisms of T-2 toxin, this review provides guidance for future research and aims to provide scientific evidence for developing effective prevention strategies and detoxification agents, thereby safeguarding livestock reproductive health and promoting sustainable development of the animal husbandry industry.

Key words: T-2 toxin, male animal reproduction, oxidative stress, inflammation, apoptosis

中图分类号:

S814.1

陈云, 陈丽圆, 宋文静, 张新科, 徐菡, 吴嘉仪, 赵翠燕, 张守全. T-2毒素对雄性动物生殖系统毒害机制的研究进展[J]. 畜牧兽医学报, 2025, 56(5): 2038-2046.

CHEN Yun, CHEN Liyuan, SONG Wenjing, ZHANG Xinke, XU Han, WU Jiayi, ZHAO Cuiyan, ZHANG Shouquan. Research Progress on the Mechanism of T-2 Toxin 's Impact on Male Animal Reproduction[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(5): 2038-2046.

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名称 Name	作用 Effect	文献 Reference
原花青素B2 Procyanidin B2	缓解各种毒素引起的氧化损伤	^{[53, 54]}
桦木酸 Betulinic acid	抗炎、抗氧化、抗病毒、抗癌、抗寄生虫和抗感染	^{[55, 56]}
单宁酸 Tannic acid	较强的抗氧化活性	^{[1, 57]}
L-精氨酸 L-arginine	抗氧化性，不仅能清除ROS，也能提高抗氧化酶活性	^{[32, 36]}
褪黑素 Melatonin	天然强效的抗氧化剂	^{[19, 58]}
叔丁基对苯二酚 Tert-butylhydroquinone	抗氧化、抗凋亡和抗炎特性	^[30]
绿茶粉 Green tea powders	解毒能力	^{[59, 60]}
槲皮素 Quercetin	抗氧化、抗炎、抗癌、镇痛、抗病毒、免疫调节	^[62-64]
α-生育酚 Alpha-tocopherol	抵抗T-2毒素诱导的毒性	^{[43, 64, 65]}
辅酶Q10 Coenzyme Q10	自由基清除剂	^[65]
左旋肉碱 L-carnitine	自由基清除剂	^[66]
硒 Selenium	抗氧化作用	^{[43, 67, 68]}

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T-2毒素对雄性动物生殖系统毒害机制的研究进展

Research Progress on the Mechanism of T-2 Toxin 's Impact on Male Animal Reproduction

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