氧化应激对母畜卵巢功能影响的研究进展

doi:10.11843/j.issn.0366-6964.2024.07.005

畜牧兽医学报 ›› 2024, Vol. 55 ›› Issue (7): 2825-2835.doi: 10.11843/j.issn.0366-6964.2024.07.005

氧化应激对母畜卵巢功能影响的研究进展

孟亚轩¹^,²^,³(), 刘彦¹^,², 王晶¹^,², 陈国顺³^,*(), 冯涛¹^,²^,³^,*()

1. 北京市农林科学院畜牧兽医研究所，北京 100097
2. 北京市农林科学院-美国俄克拉荷马州立大学动物科学联合实验室，北京 100097
3. 甘肃农业大学动物科学技术学院，兰州 730070

收稿日期:2024-01-02 出版日期:2024-07-23 发布日期:2024-07-24
通讯作者: 陈国顺,冯涛 E-mail:18793606358@163.com;chengs@gsau.edu.cn;fengtao_gs@163.com
作者简介:孟亚轩(2000-)，女，甘肃金昌人，硕士生，主要从事繁殖营养调控研究，E-mail：18793606358@163.com
基金资助:
国家自然科学基金(31972575);北京市农林科学院课题(CZZJ202205)

Research Progress in the Effect of Oxidative Stress on Ovarian Function in Female Livestock

Yaxuan MENG¹^,²^,³(), Yan LIU¹^,², Jing WANG¹^,², Guoshun CHEN³^,*(), Tao FENG¹^,²^,³^,*()

1. Institute of Animal Husbandry and Veterinary Medicine (IAHVM), Beijing Academy of Agriculture and Forestry Sciences (BAAFS), Beijing 100097, China
2. Joint Laboratory of Animal Science between IAHVM of BAAFS and Division of Agricultural Science and Natural Resource of Oklahoma State University, Beijing 100097, China
3. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China

Received:2024-01-02 Online:2024-07-23 Published:2024-07-24
Contact: Guoshun CHEN, Tao FENG E-mail:18793606358@163.com;chengs@gsau.edu.cn;fengtao_gs@163.com

摘要/Abstract

摘要：

卵巢是母畜生殖系统的重要组成部分，其功能受多种因素的调控，其中氧化应激作为一种重要的细胞生物学过程，被发现对卵巢功能产生深远影响。卵巢内氧化与抗氧化物的平衡对维持卵巢功能意义重大，卵巢内活性氧(reactive oxygen species，ROS)参与卵母细胞生长、减数分裂、排卵和其他生理过程的调节，ROS堆积可导致卵巢功能紊乱，影响优势卵泡形成，对卵母细胞成熟、受精以及随后的胚胎植入和发育均有影响。本文针对氧化应激对母畜卵巢功能的影响，进一步探究了氧化应激对母畜卵母细胞、颗粒细胞、卵泡膜细胞以及黄体的影响，深入了解其机制有助于揭示卵巢生理和病理的内在联系，为相关疾病的预防和治疗提供新的思路。

关键词: 母畜, 氧化应激, 卵巢, 卵母细胞, 颗粒细胞, 黄体, 线粒体

Abstract:

The ovary is an important component of the reproductive system of female livestock, and its function is regulated by many factors, among which oxidative stress, as an important cellular biological process, has been found to have a profound effect on the ovarian function. The balance between oxidation and antioxidants in the ovary plays a significant role in maintaining ovarian function. Reactive oxygen species (ROS) in the ovary participates in the regulation of oocyte growth, meiosis, ovulation, and other physiological processes. The accumulation of ROS can lead to ovarian dysfunction and affect the formation of dominant follicles. It has influence on oocyte maturation, fertilization, and subsequent embryo implantation and development. Aiming at the effects of oxidative stress on ovarian function of female animals, this paper further explored the effects of oxidative stress on oocytes, granulosa cells, follicular membrane cells and corpus luteum of female animals, and in-depth understanding of the mechanism will help reveal the internal relationship between ovarian physiology and pathology, and provide new ideas for the prevention and treatment of reproduction related diseases.

Key words: female livestock, oxidative stress, ovary, oocyte, granulosa cell, corpus luteum, mitochondria

中图分类号:

S814.1

孟亚轩, 刘彦, 王晶, 陈国顺, 冯涛. 氧化应激对母畜卵巢功能影响的研究进展[J]. 畜牧兽医学报, 2024, 55(7): 2825-2835.

Yaxuan MENG, Yan LIU, Jing WANG, Guoshun CHEN, Tao FENG. Research Progress in the Effect of Oxidative Stress on Ovarian Function in Female Livestock[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(7): 2825-2835.

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氧化应激对母畜卵巢功能影响的研究进展

Research Progress in the Effect of Oxidative Stress on Ovarian Function in Female Livestock

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