卵巢颗粒细胞自噬研究进展

doi:10.11843/j.issn.0366-6964.2025.04.004

摘要/Abstract

摘要：

卵巢颗粒细胞(granulosa cells, GCs)是雌性动物卵泡发育的基础保障。过去人们普遍认为GCs凋亡能调控卵泡发育。然而，近年来研究发现GCs自噬也能调控卵泡发育。在畜牧养殖行业中，卵泡发育的优劣与雌性动物繁殖率的高低息息相关，直接影响养殖场经济效益。目前，越来越多研究表明miRNAs是调控GCs自噬的因素之一。因此，本文将从GCs的来源、结构和功能、GCs自噬对卵巢的重要性、卵巢GCs自噬相关的miRNAs及其对卵泡发育的调控作用等方面的研究进展进行综述，以期为今后相关研究提供参考。

关键词: 卵巢颗粒细胞, 家畜, 细胞自噬, miRNAs

Abstract:

Ovarian granulosa cells (GCs) are the basic guarantee of follicle development in female animals. In the past, it was widely believed that apoptosis of GCs could regulate follicle development. However, recent studies have found that GCs autophagy can also regulate follicle development. In the animal husbandry industry, the quality of follicle development is closely related to the reproductive rate of female animals, which directly affects the economic benefits of livestock farms. At present, more and more studies have shown that miRNAs are one of the factors regulating autophagy in GCs. Therefore, this article will review the research progress on the origin, structure and function of GCs, the importance of GCs autophagy on the ovary, the miRNAs associated with GCs autophagy of the ovary and their regulatory effects on follicle development, in order to provide references for future related studies.

Key words: ovarian granulosa cells, domestic animals, autophagy, miRNAs

中图分类号:

S814.1

王莹, 张姣姣, 王鲜忠, 权富生. 卵巢颗粒细胞自噬研究进展[J]. 畜牧兽医学报, 2025, 56(4): 1508-1517.

WANG Ying, ZHANG Jiaojiao, WANG Xianzhong, QUAN Fusheng. Advances in Autophagy of Ovarian Granulosa Cells[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(4): 1508-1517.

图/表 2

表 1

雌性动物卵巢GCs自噬相关的miRNAs"

miRNAs	物种Species	靶基因Target gene	功能Function	作用通路Pathway	参考文献Reference
miR-23a	yak	ASK1	promote GCs autophagy and inhibit GCs apoptosis, increase the abundance of estradiol receptor α (ER-α) and β (ER-β) and the concentrations of estradiol (E₂), progesterone (P4) in yak GCs.	lncRNA MEG3/miR-23a /ASK1/JNK pathway	[52, 53]
miR-30a-5p	rat	SOCS3	inhibit autophagy and NLRP3-mediated pyroptosis in GCs.	SOCS3/mTOR/P70S6K pathway	[49]
miR-128-3p, miR-21-5p	chicken	/	regulate GCs autophagy.	/	[54]
miRNA-29-3p	chicken	PTEN	inhibit GCs autophagy and apoptosis.	PTEN/AKT/mTOR pathway	[50]
miR-129-1-3p	laying hens	MCU	promote autophagic death of GCs.	miR-129-1-3p/MCU calcium pathway	[55]
miR-486	guanz--hong dairy goat	SRSF3	promote GCs apoptosis and inhibit GCs proliferation and autophagy.	/	[56]
miR-128-3p	bovine	FOXO4/TFEB	promote GCs autophagy and inhibit GCs apoptosis.	/	[57]
miR-29b-3p	mouse	H19	inhibit GCs autophagy.	H19/miR-29b-3p pathway	[58]
miR-1298-5p	human/rat	GSR	promote GCs autophagy.	/	[59]
miR-654	mouse	STC2	promote apoptosis and autophagy.	lncRNA NEAT1/miR-654/STC2/MAPK pathway	[60]
miR-34a-5p	chicken	LEF1	promote GCs autophagy and apoptosis.	Hippo-YAP signaling pathway	[61]
miR-26b	yak	SMAD1	inhibit GCs proliferation and autophagy and promote apoptosis.	H19/miR-26b/SMAD1 Axis	[62]
miR-146b-3p	chicken	AKT1	promote GCs apoptosis and attenuate autophagy.	PI3K/AKT signaling pathway	[63]
miR-30a-5p	chicken	Beclin1	inhibit GCs autophagy and apoptosis, and promote the synthesis of steroid hormones and increase the level of oxidative stress.	/	[48]
let-7e	human	/	inhibited GCs autophagy and promoted GCs proliferation.	p21signaling pathway	[64]
miR-378d	human	/	regulate GCs autophagy and apoptosis.	/	[65]
miR-21-3p	bovine	FGF2	inhibit GCs autophagy.	AKT/mTOR pathway	[51]
miR-21-3p	bovine	VEGFA	inhibit GCs autophagy.	PI3K/AKT signaling	[66]
let-7g	mouse	IGF-1R	promote GCs autophagy.	IGF1R/AKT/mTOR signaling	[67]

表 1

图 1

参考文献 67

1	HUANG Z , WELLS D . The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome[J]. Mol Hum Reprod, 2010, 16 (10): 715- 725. doi: 10.1093/molehr/gaq031
2	NIU W , SPRADLING AC . Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary[J]. Proc Natl Acad Sci U S A, 2020, 117 (33): 20015- 20026. doi: 10.1073/pnas.2005570117
3	TURATHUM B , GAO E M , CHIAN R C . The Function of cumulus cells in oocyte growth and maturation and in subsequent ovulation and fertilization[J]. Cells, 2021, 10 (9): 2292. doi: 10.3390/cells10092292
4	DIAZ F J , WIGGLESWORTH K , EPPIG J J . Oocytes are required for the preantral granulosa cell to cumulus cell transition in mice[J]. Dev Biol, 2007, 305 (1): 300- 311. doi: 10.1016/j.ydbio.2007.02.019
5	EPPIG J J . Oocyte control of ovarian follicular development and function in mammals[J]. Reproduction, 2001, 122 (6): 829- 838. doi: 10.1530/rep.0.1220829
6	ZHANG L , JIANG S , WOZNIAK P J , et al. Cumulus cell function during bovine oocyte maturation, fertilization, and embryo development in vitro[J]. Mol Reprod Dev, 1995, 40 (3): 338- 344. doi: 10.1002/mrd.1080400310
7	OKUDAIRA Y , WAKAI T , FUNAHASHI H . Levels of cyclic-AMP and cyclic-GMP in porcine oocyte-cumulus complexes and cumulus-free oocytes derived from small and middle follicles during the first 24-hour period of in vitro maturation[J]. J Reprod Dev, 2017, 63 (2): 191- 197. doi: 10.1262/jrd.2016-156
8	TANGHE S , VAN SOOM A , NAUWYNCK H , et al. Minireview: Functions of the cumulus oophorus during oocyte maturation, ovulation, and fertilization[J]. Mol Reprod Dev, 2002, 61 (3): 414- 424. doi: 10.1002/mrd.10102
9	KIDDER G M , MHAWI A A . Gap junctions and ovarian folliculogenesis[J]. Reproduction, 2002, 123 (5): 613- 620. doi: 10.1530/rep.0.1230613
10	KONG P , YIN M , TANG C , et al. Effects of early cumulus cell removal on treatment outcomes in patients undergoing in vitro fertilization: A retrospective cohort study[J]. Front Endocrinol (Lausanne), 2021, 12, 669507. doi: 10.3389/fendo.2021.669507
11	NICHOLS J A , PEREGO M C , SCHUTZ L F , et al. Hormonal regulation of vascular endothelial growth factor A (VEGFA) gene expression in granulosa and theca cells of cattle1[J]. J Anim Sci, 2019, 97 (7): 3034- 3045. doi: 10.1093/jas/skz164
12	HOBEIKA E , ARMOUTI M , FIERRO M A , et al. Regulation of insulin-like growth factor 2 by oocyte-secreted factors in primary human granulosa cells[J]. J Clin Endocrinol Metab, 2020, 105 (1): 327- 335. doi: 10.1210/clinem/dgz057
13	DIAZ F J , WIGGLESWORTH K , EPPIG J J . Oocytes determine cumulus cell lineage in mouse ovarian follicles[J]. J Cell Sci, 2007, 120 (Pt 8): 1330- 1340.
14	STRINGER J M , ALESI L R , WINSHIP A L , et al. Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life[J]. Hum Reprod Update, 2023, 29 (4): 434- 456. doi: 10.1093/humupd/dmad005
15	ADASHI E Y , RESNICK C E , HURWITZ A , et al. Insulin-like growth factors: the ovarian connection[J]. Hum Reprod, 1991, 6 (9): 1213- 1219. doi: 10.1093/oxfordjournals.humrep.a137514
16	ZHANG M , SU Y Q , SUGIURA K , et al. Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes[J]. Science, 2010, 330 (6002): 366- 369. doi: 10.1126/science.1193573
17	RICHANI D , DUNNING K R , THOMPSON J G , et al. Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence[J]. Hum Reprod Update, 2021, 27 (1): 27- 47. doi: 10.1093/humupd/dmaa043
18	GALLUZZI L , BAEHRECKE E H , BALLABIO A , et al. Molecular definitions of autophagy and related processes[J]. EMBO J, 2017, 36 (13): 1811- 1836. doi: 10.15252/embj.201796697
19	ZHOU J , PENG X , MEI S . Autophagy in ovarian follicular development and atresia[J]. Int J Biol Sci, 2019, 15 (4): 726- 737. doi: 10.7150/ijbs.30369
20	LEVINE B , KROEMER G . Autophagy in the pathogenesis of disease[J]. Cell, 2008, 132 (1): 27- 42. doi: 10.1016/j.cell.2007.12.018
21	DOHERTY J , BAEHRECKE E H . Life, death and autophagy[J]. Nat Cell Biol, 2018, 20 (10): 1110- 1117. doi: 10.1038/s41556-018-0201-5
22	KIM J , LIM Y M , LEE M S . The role of autophagy in systemic metabolism and human-type diabetes[J]. Mol Cells, 2018, 41 (1): 11- 17.
23	D'ARCY M S . Cell death: a review of the major forms of apoptosis, necrosis and autophagy[J]. Cell Biol Int, 2019, 43 (6): 582- 592. doi: 10.1002/cbin.11137
24	TONG C , WU Y , ZHANG L , et al. Insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: Association with PI3K signaling pathway[J]. Front Endocrinol (Lausanne), 2022, 13, 1091147. doi: 10.3389/fendo.2022.1091147
25	TAKEMURA G , KANAMORI H , OKADA H , et al. Anti-apoptosis in nonmyocytes and pro-autophagy in cardiomyocytes: two strategies against postinfarction heart failure through regulation of cell death/degeneration[J]. Heart Fail Rev, 2018, 23 (5): 759- 772. doi: 10.1007/s10741-018-9708-x
26	LI D , YOU Y , BI F F , et al. Autophagy is activated in the ovarian tissue of polycystic ovary syndrome[J]. Reproduction, 2018, 155 (1): 85- 92. doi: 10.1530/REP-17-0499
27	LIU M , ZHU H , ZHU Y , et al. Guizhi Fuling Wan reduces autophagy of granulosa cell in rats with polycystic ovary syndrome via restoring the PI3K/AKT/mTOR signaling pathway[J]. J Ethnopharmacol, 2021, 270, 113821. doi: 10.1016/j.jep.2021.113821
28	LU G , WU Z , SHANG J , et al. The effects of metformin on autophagy[J]. Biomed Pharmacother, 2021, 137, 111286. doi: 10.1016/j.biopha.2021.111286
29	CHEN X , TANG H , LIANG Y , et al. Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3[J]. Biomed Pharmacother, 2021, 144, 112288. doi: 10.1016/j.biopha.2021.112288
30	GAWRILUK T R , HALE A N , FLAWS J A , et al. Autophagy is a cell survival program for female germ cells in the murine ovary[J]. Reproduction, 2011, 141 (6): 759- 765. doi: 10.1530/REP-10-0489
31	SONG Z H , YU H Y , WANG P , et al. Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice[J]. Cell Death Dis, 2015, 6 (1): e1589. doi: 10.1038/cddis.2014.559
32	BHARDWAJ J K , PALIWAL A , SARAF P , et al. Role of autophagy in follicular development and maintenance of primordial follicular pool in the ovary[J]. J Cell Physiol, 2022, 237 (2): 1157- 1170. doi: 10.1002/jcp.30613
33	LI L , FU Y C , XU J J , et al. Caloric restriction promotes the reserve of follicle pool in adult female rats by inhibiting the activation of mammalian target of rapamycin signaling[J]. Reprod Sci, 2015, 22 (1): 60- 67. doi: 10.1177/1933719114542016
34	KUMARIYA S , UBBA V , JHA R K , et al. Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective[J]. Autophagy, 2021, 17 (10): 2706- 2733. doi: 10.1080/15548627.2021.1938914
35	CHOI J , JO M , LEE E , et al. Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells[J]. Fertil Steril, 2011, 95 (4): 1482- 1486. doi: 10.1016/j.fertnstert.2010.06.006
36	KANG J W , CHO H I , LEE S M . Melatonin inhibits mTOR-dependent autophagy during liver ischemia/reperfusion[J]. Cell Physiol Biochem, 2014, 33 (1): 23- 36. doi: 10.1159/000356647
37	LIM H J , SONG H . Evolving tales of autophagy in early reproductive events[J]. Int J Dev Biol, 2014, 58 (2-4): 183- 187.
38	CHOI J Y , JO M W , LEE E Y , et al. The role of autophagy in follicular development and atresia in rat granulosa cells[J]. Fertil Steril, 2010, 93 (8): 2532- 2537. doi: 10.1016/j.fertnstert.2009.11.021
39	SHEN M , JIANG Y , GUAN Z , et al. Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy[J]. Autophagy, 2017, 13 (8): 1364- 1385. doi: 10.1080/15548627.2017.1327941
40	SHEN M , CAO Y , JIANG Y , et al. Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: Implication of an antioxidation-independent mechanism[J]. Redox Biol, 2018, 18, 138- 157. doi: 10.1016/j.redox.2018.07.004
41	CHOI J Y , JO M W , LEE E Y , et al. AKT is involved in granulosa cell autophagy regulation via mTOR signaling during rat follicular development and atresia[J]. Reproduction, 2014, 147 (1): 73- 80. doi: 10.1530/REP-13-0386
42	SONG X , SHEN Q , FAN L , et al. Dehydroepiandrosterone-induced activation of mTORC1 and inhibition of autophagy contribute to skeletal muscle insulin resistance in a mouse model of polycystic ovary syndrome[J]. Oncotarget, 2018, 9 (15): 11905- 11921. doi: 10.18632/oncotarget.24190
43	ZHANG C , HU J , WANG W , et al. HMGB1-induced aberrant autophagy contributes to insulin resistance in granulosa cells in PCOS[J]. FASEB J, 2020, 34 (7): 9563- 9574. doi: 10.1096/fj.202000605RR
44	QUAN H , GUO Y , LI S , et al. Phospholipid phosphatase 3 (PLPP3) induces oxidative stress to accelerate ovarian aging in pigs[J]. Cells, 2024, 13 (17): 1421. doi: 10.3390/cells13171421
45	DUAN H , WANG F , WANG K , et al. Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway[J]. J Anim Sci Biotechnol, 2024, 15 (1): 119. doi: 10.1186/s40104-024-01078-5
46	SCUDIERI A , VALBONETTI L , PERIC T , et al. Autophagy is involved in granulosa cell death and follicular atresia in ewe ovaries[J]. Theriogenology, 2024, 226, 236- 242. doi: 10.1016/j.theriogenology.2024.06.024
47	WANG Y , ZHAO Y , LING Z , et al. HD-sEVs in bovine follicular fluid regulate granulosa cell apoptosis and estradiol secretion through the autophagy pathway[J]. Theriogenology, 2023, 212, 91- 103. doi: 10.1016/j.theriogenology.2023.09.005
48	HE H , LI D , TIAN Y , et al. miRNA sequencing analysis of healthy and atretic follicles of chickens revealed that miR-30a-5p inhibits granulosa cell death via targeting Beclin1[J]. J Anim Sci Biotechnol, 2022, 13 (1): 55. doi: 10.1186/s40104-022-00697-0
49	HUANG Q , LI Y , CHEN Z , et al. Bushenhuoluo Decoction improves polycystic ovary syndrome by regulating exosomal miR-30a-5p/ SOCS3/mTOR/NLRP3 signaling-mediated autophagy and pyroptosis[J]. J Ovarian Res, 2024, 17 (1): 29. doi: 10.1186/s13048-024-01355-x
50	HU C , ZHAO X , CUI C , et al. miRNA-29-3p targets PTEN to regulate follicular development through the PI3K/Akt/mTOR signaling pathway[J]. Theriogenology, 2024, 214, 173- 181. doi: 10.1016/j.theriogenology.2023.10.024
51	MA L Z , TANG X R , GUO S , et al. miRNA-21-3p targeting of FGF2 suppresses autophagy of bovine ovarian granulosa cells through AKT/mTOR pathway[J]. Heriogenology, 2020, 157 (1): 226- 237.
52	HAN X , PAN Y , FAN J , et al. LncRNA MEG3 regulates ASK1/JNK axis-mediated apoptosis and autophagy via sponging miR-23a in granulosa cells of yak tertiary follicles[J]. Cell Signal, 2023, 107, 110680. doi: 10.1016/j.cellsig.2023.110680
53	HAN X H , WANG M , PAN Y Y , et al. Effect of follicle-stimulating hormone and luteinizing hormone on apoptosis, autophagy, and the release and reception of some steroid hormones in yak granulosa cells through miR-23a/ASK1 axis[J]. Cell Signal, 2024, 115, 111010. doi: 10.1016/j.cellsig.2023.111010
54	XU Z , LIU Q , NING C , et al. miRNA profiling of chicken follicles during follicular development[J]. Sci Rep, 2024, 14 (1): 2212. doi: 10.1038/s41598-024-52716-x
55	ZHU M , YAN M , CHEN J , et al. MicroRNA-129-1-3p attenuates autophagy-dependent cell death by targeting MCU in granulosa cells of laying hens under H(2)O(2)-induced oxidative stress[J]. Poult Sci, 2023, 102 (10): 103006. doi: 10.1016/j.psj.2023.103006
56	LIU S , BU Q , TONG J , et al. miR-486 responds to apoptosis and autophagy by repressing SRSF3 expression in ovarian granulosa cells of dairy goats[J]. Int J Mol Sci, 2023, 24 (10): 8751. doi: 10.3390/ijms24108751
57	YING W , YUNQI Z , DEJI L , et al. Follicular fluid HD-sevs-mir-128-3p is a key molecule in regulating bovine granulosa cells autophagy[J]. Theriogenology, 2024, 226, 263- 276. doi: 10.1016/j.theriogenology.2024.06.022
58	WU P , ZHU Y , LI J , et al. Guizhi Fuling Wan inhibits autophagy of granulosa cells in polycystic ovary syndrome mice via H19/miR-29b-3p[J]. Gynecol Endocrinol, 2023, 39 (1): 2210232. doi: 10.1080/09513590.2023.2210232
59	XU C , LUO M , LIU X , et al. MicroRNA-1298-5p in granulosa cells facilitates cell autophagy in polycystic ovary syndrome by suppressing glutathione-disulfide reductase[J]. Cell Tissue Res, 2023, 392 (3): 763- 778. doi: 10.1007/s00441-023-03747-9
60	LIU YX , KE Y , QIU P , et al. LncRNA NEAT1 inhibits apoptosis and autophagy of ovarian granulosa cells through miR-654/STC2-mediated MAPK signaling pathway[J]. Exp Cell Res, 2023, 424 (1): 113473. doi: 10.1016/j.yexcr.2023.113473
61	HAN S , ZHAO X , ZHANG Y , et al. MiR-34a-5p promotes autophagy and apoptosis of ovarian granulosa cells via the Hippo-YAP signaling pathway by targeting LEF1 in chicken[J]. Poult Sci, 2023, 102 (2): 102374. doi: 10.1016/j.psj.2022.102374
62	YAO Y , WANG Y , WANG F , et al. BMP15 modulates the H19/miR-26b/SMAD1 axis influences yak granulosa cell proliferation, autophagy, and apoptosis[J]. Reprod Sci, 2023, 30 (4): 1266- 1280. doi: 10.1007/s43032-022-01051-5
63	WEI Q , XUE H , SUN C , et al. Gga-miR-146b-3p promotes apoptosis and attenuate autophagy by targeting AKT1 in chicken granulosa cells[J]. Theriogenology, 2022, 190, 52- 64. doi: 10.1016/j.theriogenology.2022.07.019
64	LI Y , LIU Y D , ZHOU X Y , et al. Let-7e modulates the proliferation and the autophagy of human granulosa cells by suppressing p21 signaling pathway in polycystic ovary syndrome without hyperandrogenism[J]. Mol Cell Endocrinol, 2021, 535, 111392. doi: 10.1016/j.mce.2021.111392
65	CHEN Q , LI Z , XU Z , et al. miR-378d is involved in the regulation of apoptosis and autophagy of and E2 secretion from cultured ovarian granular cells treated by sodium fluoride[J]. Biol Trace Elem Res, 2021, 199 (11): 4119- 4128. doi: 10.1007/s12011-020-02524-x
66	MA L , ZHENG Y , TANG X , et al. miR-21-3p inhibits autophagy of bovine granulosa cells by targeting VEGFA via PI3K/AKT signaling[J]. Reproduction, 2019, 158 (5): 441- 452. doi: 10.1530/REP-19-0285
67	ZHOU J , YAO W , LIU K , et al. MicroRNA let-7g regulates mouse granulosa cell autophagy by targeting insulin-like growth factor 1 receptor[J]. Int J Biochem Cell Biol, 2016, 78, 130- 140. doi: 10.1016/j.biocel.2016.07.008

[1]	李笑微, 田微, 刘媛, 李惠侠. 高温应激下湖羊卵巢颗粒细胞m⁶A甲基化修饰差异研究[J]. 畜牧兽医学报, 2025, 56(4): 1712-1721.
[2]	侯宛辰, 徐童. 大麻二酚通过BRD4/AMPK/mTOR信号通路拮抗双酚A诱导的猪肠上皮细胞凋亡和自噬[J]. 畜牧兽医学报, 2025, 56(4): 1919-1933.
[3]	解雅茹, 金昊延, 孔辰, 蔡蓓, 张令锴. CRISPR/Cas9系统在家畜生殖细胞中的研究进展[J]. 畜牧兽医学报, 2025, 56(2): 479-491.
[4]	何雨, 王翔宇, 狄冉, 储明星, 梁琛. BMP4/SMAD4通过下调GJA1基因表达影响绵羊卵巢颗粒间隙连接活性[J]. 畜牧兽医学报, 2025, 56(2): 679-688.
[5]	王艺, 侯露露, 方菲, 高林英, 谢淑敏, 王雨. 氟通过自噬和铁死亡途径诱发肉鸡小肠氧化损伤[J]. 畜牧兽医学报, 2025, 56(1): 442-454.
[6]	高语馨, 刘青, 陈继兰, 麻慧. miRNAs介导寄生虫和宿主互作机制的研究进展[J]. 畜牧兽医学报, 2024, 55(9): 3812-3823.
[7]	李京宇, 陈金铭, 张明一, 赵姗姗, 陶德良, 宋军科, 杨新, 樊莹莹, 赵光辉. 犬新孢子虫miRNAs的鉴定与分析[J]. 畜牧兽医学报, 2024, 55(7): 3085-3093.
[8]	常馨丹, 胡帆, 伍志武, 叶炳森, 刘铁海, 林杰, 贺志雄, 谭支良. 日粮添加高比例过瘤胃脂肪对生长肉用绵羊采食行为的影响[J]. 畜牧兽医学报, 2024, 55(3): 1077-1084.
[9]	刘阳光, 章会斌, 文浩宇, 谢帆, 赵世明, 丁月云, 郑先瑞, 殷宗俊, 张晓东. 猪卵泡液外泌体处理卵巢颗粒细胞的SNP/Indel筛选分析[J]. 畜牧兽医学报, 2024, 55(2): 576-586.
[10]	段香茹, 康佳, 杨若晨, 单新雨, 李太春, 赵雯, 张英杰, 刘月琴. L-半胱氨酸对绵羊卵巢颗粒细胞增殖、凋亡和类固醇激素分泌的影响[J]. 畜牧兽医学报, 2024, 55(1): 179-191.
[11]	刘悦阳, 李梦媛, 聂雪伊, 马亚博, 侯雨欣, 马伯利, 杨易, 徐金瑞. 钙结合蛋白S100A4对BCG感染THP-1细胞自噬的调控作用[J]. 畜牧兽医学报, 2024, 55(1): 311-322.
[12]	王崇年, 于嘉霖, 宫照乾, 吴晓玲, 邓光存. 脂肪分化相关蛋白2对BCG诱导小鼠传代巨噬细胞自噬的调控作用[J]. 畜牧兽医学报, 2023, 54(5): 2134-2146.
[13]	胡亚美, 宋湘容, 黄亮, 张璐通, 高磊, 庞卫军, 杨公社, 褚瑰燕. FGF21增强线粒体功能抑制猪卵巢颗粒细胞凋亡[J]. 畜牧兽医学报, 2023, 54(3): 1034-1045.
[14]	罗睿杰, 曹素英. 大家畜多能干细胞的研究进展与应用前景[J]. 畜牧兽医学报, 2023, 54(10): 4003-4015.
[15]	迟长安, 彭思祺, 申长庆, 王世成, 涂静怡, 肖雄, 邱小燕. 家畜认知功能及其调控机制[J]. 畜牧兽医学报, 2022, 53(8): 2403-2416.