肠道菌群及其代谢产物调节动物线粒体功能的研究进展

doi:10.11843/j.issn.0366-6964.2023.01.005

摘要/Abstract

摘要： 线粒体是动物细胞生产能量的主要场所，可参与三磷酸腺苷的产生、细胞线粒体Ca²⁺稳态的维持，在调节动物机体能量代谢方面发挥重要的作用。目前，研究发现肠道微生物及其代谢产物可影响细胞线粒体代谢水平和功能，参与调节机体营养物质代谢周转速度，最终影响畜禽生长发育及饲料转化效率等。本文在总结线粒体生物学功能的基础上，重点阐述了肠道微生物及其代谢产物对线粒体功能的调节作用及影响因素，旨在为饲粮营养手段介导肠道微生物-宿主线粒体途径调节动物生长发育和肠道健康提供理论参考。

关键词: 线粒体功能, 肠道微生物, 代谢产物, 肠道健康

Abstract: Mitochondria are the primary energy-generating sites in animal cells, where they can participate in the production of triphosphate and the maintenance of a constant state of mitochondrial Ca²⁺, which is crucial for animal health and energy metabolism. Studies have found that gut microflora and their metabolites can mediate the level and function of mitochondrial metabolism, which then affects the growth and development of the turnover of nutrient metabolism, feed conversion efficiency, etc. Based on the summary of the biological function of mitochondria, this review focuses on the influence of gut microflora and their metabolites on mitochondrial activity and the influencing factors, aiming to provide a theoretical reference for regulating growth and intestinal health of animals by the dietary nutrition-mediated intestinal microbial-host mitochondrial pathway.

Key words: mitochondrial function, intestinal microorganism, metabolites, intestinal health

中图分类号:

Q938.15
Q244

袁铜, 黄靓, 杨琳, 王文策, 朱勇文. 肠道菌群及其代谢产物调节动物线粒体功能的研究进展[J]. 畜牧兽医学报, 2023, 54(1): 48-57.

YUAN Tong, HUANG Liang, YANG Lin, WANG Wence, ZHU Yongwen. Regulation of Mitochondrial Function by Gut Microbiota and Their Metabolites in Animal[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(1): 48-57.

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