反刍动物胃肠道上皮屏障功能及与微生物互作研究

doi:10.11843/j.issn.0366-6964.2023.05.004

摘要/Abstract

摘要： 动物的胃肠道是直接与外部环境接触的部位,时刻暴露于各种外源和内源物质当中。因此,胃肠道中具有功能性上皮屏障,以防止各种物质侵入组织内部。胃肠道微生物在维持胃肠道上皮屏障稳态和强化方面发挥重要作用。胃肠道上皮屏障与微生物相互作用调节宿主胃肠道生长发育、新陈代谢和免疫功能的建立,而宿主胃肠道上皮屏障功能的建立也会影响胃肠道微生物的定殖与分布。本综述总结了胃肠道上皮屏障的结构与功能,以及胃肠道微生物和胃肠道上皮屏障之间的相互作用关系。旨在为胃肠道微生物与胃肠道上皮屏障间关系的研究提供参考。

关键词: 胃肠道上皮屏障, 紧密连接, 胃肠道微生物, 反刍动物

Abstract: The gastrointestinal tract of animals is the part which directly contacts the external environment and is always exposed to various exogenous and endogenous substances. Hence, there are functional epithelial barriers in the gastrointestinal tract to prevent various substances from invading the tissue. Gastrointestinal microbes play an important role in maintaining the homeostasis and strengthening of the gastrointestinal epithelial barrier. The gastrointestinal epithelial barrier interacts with microorganisms to regulate the growth, development, metabolism and immune function of the host gastrointestinal tract, and the establishment of the gastrointestinal epithelial barrier function of the host affects the colonization and distribution of gastrointestinal microorganisms. This review summarizes the structure and function of the gastrointestinal epithelial barrier and the interaction between gastrointestinal microorganisms and gastrointestinal epithelial barrier. Aiming to provide reference for the study of the relationship between gastrointestinal microorganisms and gastrointestinal epithelial barrier.

Key words: gastrointestinal epithelial barrier, tight junction, gastrointestinal tract microor-ganisms, ruminant

中图分类号:

S811.6

杜海东, 娜仁花. 反刍动物胃肠道上皮屏障功能及与微生物互作研究[J]. 畜牧兽医学报, 2023, 54(5): 1804-1814.

DU Haidong, NA Renhua. Study on Gastrointestinal Epithelial Barrier Function and Interaction with Microorganisms in Ruminants[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1804-1814.

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