Acta Veterinaria et Zootechnica Sinica ›› 2023, Vol. 54 ›› Issue (6): 2280-2287.doi: 10.11843/j.issn.0366-6964.2023.06.008

• REVIEW • Previous Articles     Next Articles

Research Progress of Ferroptosis in Bacterial Infection

MAO Peng1,2,3, WANG Zhihao1,2,3, LI Jianji1,2,3, CUI Luying1,2,3, ZHU Guoqiang1,2,3, MENG Xia1,2,3, DONG Junsheng1,2,3, WANG Heng1,2,3*   

  1. 1. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China;
    2. International Research Laboratory of Prevention and Control of Important Animal Infectious Diseases and Zoonotic Diseases of Jiangsu Higher Education Institutions, Yangzhou 225009, China;
    3. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education, Yangzhou 225009, China
  • Received:2022-07-21 Online:2023-06-23 Published:2023-06-16

Abstract: Ferroptosis is a newly discovered programmed cell death pattern characterized by iron-dependent accumulation of lipid peroxidation. Iron metabolism disorder and oxidative stress play an important role in bacterial infection, and it has been proved that some bacteria could induce host cell death by ferroptosis. In this paper, the effects of bacterial infection on host iron metabolism and the mechanism of bacteria-induced ferroptosis were reviewed, in order to provide new research ideas for the prevention of bacterial infection in animals.

Key words: ferroptosis, bacterial infection, iron metabolism, oxidative stress

CLC Number: