circRNA作为ceRNA调控畜禽重要经济性状的研究进展

doi:10.11843/j.issn.0366-6964.2023.06.001

Abstract

Abstract: Competing endogenous RNAs (ceRNA) refers to RNAs harboring the same microRNA response elements (MRE), competitively binding the miRNA to regulate gene expression post-transcriptionally. Eventually, the biological functions of cells are altered. The efficiency of ceRNA is affected by the cellular environment, miRNA activity, intermolecular affinity with RNAs, etc. Both circular RNA (circRNA) and long non-coding RNA (lncRNA) can act as ceRNA; circRNA is more effective based on its higher stability and conservation, enabling its transition into different tissues. This paper discussed the factors affecting the ceRNA mechanism, then reviewed the research progress of ceRNA-mediated regulation of circRNAs in muscle growth, fat deposition, mammary gland and follicular development in animals. In the hope of providing new insight for the in-depth study of the ceRNA regulatory network in the development of critical economic traits for animals.

Key words: competing endogenous RNAs, influence factor, circRNA, economic trait, regulatory mechanism

CLC Number:

S813

AN Zongqi, ZHAN Siyuan, LI Li, ZHANG Hongping. ceRNA-mediated Function of CircRNA on Critical Economic Traits in Animals[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2215-2222.

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ceRNA-mediated Function of CircRNA on Critical Economic Traits in Animals

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