哺乳动物胎盘营养感应研究进展

doi:10.11843/j.issn.0366-6964.2022.05.001

Abstract

Abstract: Changes in maternal nutrition during gestation will affect the growth and development of the fetus. Placenta is an important interface for gas, nutrition and metabolite communication between maternal and fetus. The mammalian placental nutrition sensing system responds to the changes in maternal and fetal signals to ensure maternal health and promote the fetal growth and development. In view of its important role of the placental nutrition sensing system to mammalian reproduction, this article summarizes the effects of relevant signaling pathways including mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), hexosamine signaling pathway (Hexosamine), hlycogen synthase kinase 3 (GSK-3), insulin/insulin-like growth factor signaling pathway (IIS) and others on placental nutrition sensing and placental nutrient distribution to response nutrient changes in dam, subsequently to influence fetal development during pregnancy. All above are expected to provide theoretical basis for the breeding of mammals.

Key words: mammalian, placental nutrition sensing, placental nutrient distribution, signaling pathway

CLC Number:

S814.1

LIU Yueshuai, LIU Yan, CAO Xin, FENG Tao. Research Progress on Mammalian Placental Nutrition Sensing[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(5): 1321-1333.

References 147

[1]	PARISI F,SAVASI V M,DI BARTOLO I,et al.Associations between first trimester maternal nutritional score,early markers of placental function,and pregnancy outcome[J].Nutrients,2020,12(6):1799.
[2]	LIU G P,ZHANG C X,WANG Y T,et al.New exon and accelerated evolution of placental gene Nrk occurred in the ancestral lineage of placental mammals[J].Placenta,2021,114:14-21.
[3]	刘炀.亮氨酸对猪胎盘滋养层细胞增殖及氨基酸转运的影响[D].广州:华南农业大学,2016.LIU Y.Effect of leucine on the proliferation and amino acid transport of porcine trophectoderm cell[D].Guangzhou:South China Agricultural University,2016.(in Chinese)
[4]	胡健,姚姣姣,颜培实.母猪胎盘效率及胎盘中糖代谢相关基因的研究[C]//中国畜牧兽医学会2014年家畜环境卫生学分会学术年会论文集.武汉:中国畜牧兽医学会家畜环境卫生学分会,2014:154-160.HU J,YAO J J,YAN P S.Study on placenta efficiency of sows and related genes of glucose metabolism in placenta[C]//Proceedings of the 2014 Annual Meeting of the Animal Environmental Hygiene Branch of the Chinese Association of Animal Science and Veterinary Medicine.Wuhan:Livestock Environmental Hygiene Branch of China Animal Husbandry and Veterinary Society,2014:154-160.(in Chinese)
[5]	DÍAZ P,POWELL T L,JANSSON T.The role of placental nutrient sensing in maternal-fetal resource allocation[J].Biol Reprod,2014,91(4):82.
[6]	DIMASUAY K G,BOEUF P,POWELL T L,et al.Placental responses to changes in the maternal environment determine fetal growth[J].Front Physiol, 2016,7:12.
[7]	TOWN S C,PATTERSON J L,PEREIRA C Z,et al.Embryonic and fetal development in a commercial dam-line genotype[J].Anim Reprod Sci,2005,85(3-4):301-316.
[8]	刘俊泽,赵靓瑜,黄凯,等.日粮添加发酵豆渣对母猪产仔性能、胎盘效率和胎盘营养物质转运的影响[J].畜牧与兽医,2020,52(8):16-21.LIU J Z,ZHAO L Y,HUANG K,et al.Effect of fermented bean dregs supplementation on the reproductive performance,placental efficiency,and placental nutrient transportation in sows[J].Animal Husbandry & Veterinary Medicine,2020,52(8):16-21.(in Chinese)
[9]	KAUFMAN M R,BROWN T L.AMPK and placental progenitor cells[J].Exp Suppl,2016,107:73-79.
[10]	CHASSEN S,JANSSON T.Complex,coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR[J].Biochim Biophys Acta (BBA)-Mol Basis Dis,2020,1866(2):165373.
[11]	TSAI K,TULLIS B,JENSEN T,et al.Differential expression of mTOR related molecules in the placenta from gestational diabetes mellitus (GDM),intrauterine growth restriction (IUGR) and preeclampsia patients[J].Reprod Biol,2021,21(2):100503.
[12]	SHAO X,CAO G M,CHEN D J,et al.Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply[J].Proc Natl Acad Sci U S A,2021,118(3):e2017092118.
[13]	刘晓倩,靳兰杰,董艳秋,等.DNA甲基化调控牛AQP1基因的胎盘特异性印记[J].畜牧兽医学报,2021,52(8):2181-2189.LIU X Q,JIN L J,DONG Y Q,et al.DNA methylation regulate the genomic imprinting of AQP1 gene specific in bovine placenta[J].Acta Veterinaria et Zootechnica Sinica,2021,52(8):2181-2189.(in Chinese)
[14]	BAMFO J E A K,ODIBO A O.Diagnosis and management of fetal growth restriction[J].J Pregnancy,2011,2011:640715.
[15]	KENNEDY L M,TONG S,ROBINSON A J,et al.Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight[J].BMC Med,2020,18(1):395.
[16]	ZHANG S,REGNAULT T R H,BARKER P L,et al.Placental adaptations in growth restriction[J].Nutrients,2015,7(1):360-389.
[17]	GACCIOLI F,LAGER S,POWELL T L,et al.Placental transport in response to altered maternal nutrition[J].J Dev Orig Health Dis,2013,4(2):101-115.
[18]	耿超宇.哺乳动物妊娠期母体与胎儿之间细胞通讯网络的研究[D].天津:天津商业大学,2013.GENG C Y.Cellular communications network in mammal between maternal and fetal during gestation period[D].Tianjin:Tianjin University of Commerce,2013.(in Chinese)
[19]	ONO K,FURUGEN A,KUROSAWA Y,et al.Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array:induction of xCT/SLC7A11 in human placental BeWo cells[J].Placenta,2019,75:34-41.
[20]	王洪利,刘新勃,迟灵芝.母猪妊娠期营养对仔猪体重变化的影响[J].中国饲料,2019(20):12-16.WANG H L,LIU X B,CHI L Z.Effects of sow nutrition during gestation on piglets birth weight change[J].China Feed,2019(20):12-16.(in Chinese)
[21]	孟晓瑜,王艳,思美丽,等.胎盘胰岛素样生长因子1、胰岛素样生长因子2与妊娠期糖尿病巨大儿糖脂代谢的关系[J].医学综述,2016,22(19):3899-3901,3905.MENG X Y,WANG Y,SI M L,et al.Relationship between insulin-like growth factor-1,insulin-like growth factor-2 and the macrosomia glucose and lipid metabolism associated with gestational diabetes mellitus[J].Medical Recapitulate,2016,22(19):3899-3901,3905.(in Chinese)
[22]	冯佑民,朱菊红,张新堂,等.胰岛素作用原理的研究——Ⅷ.人胎盘细胞膜胰岛素受体[J].生物化学与生物物理学报,1982(2):43-49.FENG Y M,ZHU J H,ZHANG X T,et al.Studies on the mechanism of insulin action——Ⅷ.the insulin receptors on the membrane of the human placenta[J].Acta Biochimica et Biophysica Sinica,1982(2):43-49.(in Chinese)
[23]	FANDIÑO J,TOBA L,GONZÁLEZ-MATÍAS L C,et al.Perinatal undernutrition,metabolic hormones,and lung development[J]. Nutrients, 2019,11(12):2870.
[24]	JANSSON T,POWELL T L.Role of placental nutrient sensing in developmental programming[J].Clin Obstet Gynecol,2013, 56(3):591-601.
[25]	LARQUÉ E,RUIZ-PALACIOS M,KOLETZKO B.Placental regulation of fetal nutrient supply[J].Curr Opin Clin Nutr Metab Care,2013,16(3):292-297.
[26]	JANSSON N,ROSARIO F J,GACCIOLI F,et al.Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies[J].J Clin Endocrinol Metab,2013,98(1):105-113.
[27]	余虹,张海洋.孕前体质指数、年龄、胎儿性别和分娩方式与新生儿体重的关系[J].上海医药,2020,41(16):60-62.YU H,ZHANG H Y.Relationship between pre-pregnancy body mass index,age,fetal gender,and mode of delivery and neonatal weight[J].Shanghai Medical & Pharmaceutical Journal,2020,41(16):60-62.(in Chinese)
[28]	LAZO-DE-LA-VEGA-MONROY M L,MATA-TAPIA K A,GARCIA-SANTILLAN J A,et al.Association of placental nutrient sensing pathways with birth weight[J].Reproduction,2020,160(3):455-468.
[29]	CHEN Y Y,ROSARIO F J,SHEHAB M A,et al.Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR[J].Clin Sci (Lond),2015,129(12):1131-1141.
[30]	周坚,黎丽红,朱斌,等.胰岛素样生长因子-Ⅱ与胎儿生长迟缓的探讨[J].中华围产医学杂志,2000,3(1):36.ZHOU J,LI L H,ZHU B,et al.Insulin-like growth factor-Ⅱ and fetal growth retardation[J].Chinese Journal of Perinatal Medicine,2000,3(1):36.(in Chinese)
[31]	ONO K,FURUGEN A,KUROSAWA Y,et al.Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array:induction of xCT/SLC7A11 in human placental BeWo cells[J].Placenta,2019,75:34-41.
[32]	王红梅,杜美蓉.人类胎盘滋养层细胞的分化与妊娠相关疾病[J].生命科学,2017,29(1):15-20.WANG H M,DU M R.Human placental trophoblast differentiation and related diseases[J].Chinese Bulletin of Life Sciences,2017,29(1):15-20.(in Chinese)
[33]	HART B,MORGAN E,ALEJANDRO E U.Nutrient sensor signaling pathways and cellular stress in fetal growth restriction[J].J Mol Endocrinol,2019,62(2):R155-R165.
[34]	KIM S W,WEAVER A C,SHEN Y B,et al.Improving efficiency of sow productivity:nutrition and health[J].J Anim Sci Biotechnol, 2013, 4(1):26.
[35]	PARDO C E,BÉRARD J,KREUZER M,et al.Intrauterine crowding impairs formation and growth of secondary myofibers in pigs[J].Animal,2013,7(3):430-438.
[36]	冯涛,韦尚丽,曹忻,等.氨基葡萄糖调控仔猪初生重和均匀度的应用及机理[J].中国畜牧兽医,2019,46(3):740-746.FENG T,WEI S L,CAO X,et al.Application and mechanism of glucosamine in regulating birth weight and uniformity of piglets[J].China Animal Husbandry & Veterinary Medicine,2019,46(3):740-746.(in Chinese)
[37]	韦尚丽,郑琛,刘彦,等.猪胎盘屏障的研究进展[J].畜牧与兽医,2021,53(3):148-154.WEI S L,ZHENG C,LIU Y,et al.Progress in research on the porcine placental barrier[J].Animal Husbandry & Veterinary Medicine,2021,53(3):148-154.(in Chinese)
[38]	KIM J,SONG G,WU G Y,et al.Arginine,leucine,and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway[J].Biol Reprod,2013,88(5):113.
[39]	ANTHONY J C,ANTHONY T G,KIMBALL S R,et al.Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine[J].J Nutr,2001,131(3):856S-860S.
[40]	DOBERENZ J,BIRKENFELD C,KLUGE H,et al.Effects of L-carnitine supplementation in pregnant sows on plasma concentrations of insulin-like growth factors,various hormones and metabolites and chorion characteristics[J].J Anim Physiol Anim Nutr,2006,90(11-12):487-499.
[41]	STERLE J A,CANTLEY T C,LAMBERSON W R,et al.Effects of recombinant porcine somatotropin on placental size,fetal growth,and IGF-I and IGF-II concentrations in pigs[J].J Anim Sci,1995,73(10):2980-2985.
[42]	ROBERTS C T,SOHLSTROM A,KIND K L,et al.Altered placental structure induced by maternal food restriction in guinea pigs:a role for circulating IGF-II and IGFBP-2 in the mother?[J].Placenta,2001,22 Suppl A:S77-S82.
[43]	刘晴,黄华,唐景春,等.复合益生菌菌剂对母猪生产性能和肠道菌群生态的影响[J].家畜生态学报,2016,37(2):72-76.LIU Q,HUANG H,TANG J C,et al.Effect of probiotic complex on the production performance and intestinal flora of sow[J].Acta Ecologae Animalis Domastici,2016,37(2):72-76.(in Chinese)
[44]	冯涛,马文清,白佳桦,等.N-氨甲酰谷氨酸在调控仔猪初生重中的应用及其作用机理[J].中国畜牧杂志,2019,55(4):29-33.FENG T,MA W Q,BAI J H,et al.Application of N-carbamylglutamate in regulating piglet birth weight and its mechanism[J].Chinese Journal of Animal Science,2019,55(4):29-33.(in Chinese)
[45]	LAPLANTE M,SABATINI D M.mTOR signaling in growth control and disease[J].Cell,2012,149(2):274-293.
[46]	GUPTA M B,JANSSON T.Novel roles of mechanistic target of rapamycin signaling in regulating fetal growth[J].Biol Reprod,2019,100(4):872-884.
[47]	YANG S B,WANG J.Estrogen activates AMP-Activated protein kinase in human endothelial cells via ERβ/Ca2+/calmodulin-dependent protein kinase kinase β pathway[J].Cell Biochem Biophys,2015,72(3):701-707.
[48]	BIENSEN N J,WILSON M E,FORD S P.The impact of either a Meishan or Yorkshire uterus on Meishan or Yorkshire fetal and placental development to days 70,90,and 110 of gestation[J].J Anim Sci,1998,76(8):2169-2176.
[49]	邱益彬,庄站伟,周身娉,等.出生季节和胎次对美系、加系杜洛克纯种仔猪初生重的影响[J].畜牧与兽医,2020,52(12):9-14.QIU Y B,ZHUANG Z W,ZHOU S P,et al.The effect of birth season and parity on the birth weight of Duroc purebred piglets of American and Canadian origins[J].Animal Husbandry & Veterinary Medicine,2020,52(12):9-14.(in Chinese)
[50]	JANSSON T,POWELL T L.Placental nutrient transfer and fetal growth[J].Nutrition,2000,16(7-8):500-502.
[51]	JANSSON T,POWELL T L.Human placental transport in altered fetal growth:does the placenta function as a nutrient sensor?-A review[J].Placenta,2006,27 Suppl:91-97.
[52]	朱信信,尚晨光,任雅丽,等.胰岛素抵抗及子宫内膜增殖大鼠模型中脂肪因子和PI3K/AKT信号通路相关蛋白的表达[J].实用妇产科杂志,2021,37(1):41-46.ZHU X X,SHANG C G,REN Y L,et al.Insulin resistance and endometrial hyperplasia alter the adiponectin system and PI3K/AKT signaling in rats[J].Journal of Practical Obstetrics and Gynecology,2021,37(1):41-46.(in Chinese)
[53]	HUSSAIN T,TAN B,MURTAZA G,et al.Role of dietary amino acids and nutrient sensing system in pregnancy associated disorders[J].Front Pharmacol,2020,11:586979.
[54]	KILBERG M S,SHAN J X,SU N.ATF4-dependent transcription mediates signaling of amino acid limitation[J].Trends Endocrinol Metab,2009,20(9):436-443.
[55]	ACHARYA G,ALBRECHT C,BENTON S J,et al.IFPA Meeting 2011 workshop report I:placenta:predicting future health;roles of lipids in the growth and development of feto-placental unit;placental nutrient sensing;placental research to solve clinical problems-A translational approach[J].Placenta,2012,33 Suppl:S4-S8.
[56]	ROSARIO F J,KANAI Y,POWELL T L,et al.Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells[J].J Physiol,2013,591(3):609-625.
[57]	SARBASSOV D D,ALI S M,SENGUPTA S,et al.Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB[J]. Mol Cell,2006,22(2):159-168.
[58]	JANSSON T,AYE I L M H,GOBERDHAN D C I.The emerging role of mTORC1 signaling in placental nutrient-sensing[J]. Placenta,2012,33 Suppl 2:e23-e29.
[59]	ROOS S,JANSSON N,PALMBERG I,et al.Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth[J].J Physiol,2007,582(1):449-459.
[60]	NIJLAND M J,SCHLABRITZ-LOUTSEVITCH N E,HUBBARD G B,et al.Non-human primate fetal kidney transcriptome analysis indicates mammalian target of rapamycin (mTOR) is a central nutrient-responsive pathway[J].J Physiol,2007, 579(3):643-656.
[61]	YIU J H C,CHEUNG S W M,CAI J L,et al.TLR5 supports development of placental labyrinthine zone in mice[J].Front Cell Dev Biol,2021,9:711253.
[62]	ARSHAM A M,HOWELL J J,SIMON M C.A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets[J].J Biol Chem,2003,278(32):29655-29660.
[63]	TUULI M G,LONGTINE M S,NELSON D M.Review:oxygen and trophoblast biology-A source of controversy[J].Placenta, 2011, 32 Suppl 2:S109-S118.
[64]	HALLORAN K M,STENHOUSE C,WU G Y,et al.Arginine,Agmatine,and Polyamines:key regulators of conceptus development in mammals[J].Adv Exp Med Biol,2021,1332:85-105.
[65]	张新颖,毛景东,杨晓燕,等.AMPK/mTOR信号通路的研究进展[J].微生物学杂志,2019,39(3):109-116.ZHANG X Y,MAO J D,YANG X Y,et al.Advances in AMPK/mTOR signaling path[J].Journal of Microbiology,2019,39(3):109-116.(in Chinese)
[66]	LORCA R A,HOUCK J A,LAURENT L C,et al.High altitude regulates the expression of AMPK pathways in human placenta[J].Placenta,2021,104:267-276.
[67]	CAREY E A K,ALBERS R E,DOLIBOA S R,et al.AMPK knockdown in placental trophoblast cells results in altered morphology and function[J].Stem Cells Dev,2014,23(23):2921-2930.
[68]	SKEFFINGTON K L,HIGGINS J S,MAHMOUD A D,et al.Hypoxia,AMPK activation and uterine artery vasoreactivity[J].J Physiol,2016,594(5):1357-1369.
[69]	BIGHAM A W,JULIAN C G,WILSON M J,et al.Maternal PRKAA1 and EDNRA genotypes are associated with birth weight,and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude[J].Physiol Genomics,2014,46(18):687-697.
[70]	ZHAN X,XIE Y R,SUN L P,et al.Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells[J].Reprod Fertil Dev,2021,33(12):700-712.
[71]	张秀娟.猪细小病毒及其非结构蛋白NS1和NS2诱导猪胎盘滋养层细胞自噬作用与机制研究[D].杨凌:西北农林科技大学,2020.ZHANG X J.The effects and mechanism of porcine placental trophoblast cell autophagy induced by porcine parvovirus and its non-structural proteins NS1 and NS2[D].Yangling:Northwest A&F University,2020.(in Chinese)
[72]	董书圣.高背膘妊娠母猪胎盘脂肪沉积及其MARK4调控机制研究[D].南京:南京农业大学,2017.DONG S S.Studies on fat deposition and MARK4 regulatory mechanism in placental of sows with high backfat thickness[D].Nanjing:Nanjing Agricultural University,2017.(in Chinese)
[73]	尹诚.TH与IIS信号通路对杂色鲍幼虫能量代谢的调控[D].厦门:集美大学,2015.YIN C.TH/IIS signaling pathways regulat the energy metabolism in larva of haliotis diversicolor[D].Xiamen:Jimei University, 2015.(in Chinese)
[74]	LIU Y,MATTILA J,HIETAKANGAS V.Systematic screen for drosophila transcriptional regulators phosphorylated in response to insulin/mTOR pathway[J].G3 (Bethesda),2020,10(8):2843-2849.
[75]	TEMPLEMAN N M,MURPHY C T.Regulation of reproduction and longevity by nutrient-sensing pathways[J].J Cell Biol,2018,217(1):93-106.
[76]	WERNER H,WEINSTEIN D,BENTOV I.Similarities and differences between insulin and IGF-I:structures,receptors,and signalling pathways[J].Arch Physiol Biochem,2008,114(1):17-22.
[77]	FU Z,GILBERT E,LIU D M.Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes[J]. Curr Diabetes Rev,2013,9(1):25-53.
[78]	TANIGUCHI C M,EMANUELLI B,KAHN C R.Critical nodes in signalling pathways:insights into insulin action[J].Nat Rev Mol Cell Biol,2006,7(2):85-96.
[79]	HANOVER J A,KRAUSE M W,LOVE D C.The hexosamine signaling pathway:o-GlcNAc cycling in feast or famine[J]. Biochim Biophys Acta (BBA)-Gen Subj,2010,1800(2):80-95.
[80]	BAZER F W,THATCHER W W.Chronicling the discovery of interferon tau[J].Reproduction,2017,154(5):F11-F20.
[81]	BAZER F W,BURGHARDT R C,JOHNSON G A,et al.Mechanisms for the establishment and maintenance of pregnancy:synergies from scientific collaborations[J].Biol Reprod,2018,99(1):225-241.
[82]	SPENCER T E,JOHNSON G A,BURGHARDT R C,et al.Progesterone and placental hormone actions on the uterus:insights from domestic animals[J].Biol Reprod,2004,71(1):2-10.
[83]	KIM J,SONG G,WU G Y,et al.Functional roles of fructose[J].Proc Natl Acad Sci U S A,2012,109(25):E1619-E1628.
[84]	WANG X Q,LI D F,WU G Y,et al.Functional roles of fructose:crosstalk between O-linked glycosylation and phosphorylation of Akt-TSC2-MTOR cell signaling cascade in ovine trophectoderm cells[J].Biol Reprod,2016,95(5):102.
[85]	STEELE V S,FROSETH J A.Effect of gestational age on the biochemical composition of porcine placental glycosaminoglycans[J]. Proc Soc Exp Biol Med,1980,165(3):480-485.
[86]	VALLET J L,FREKING B A.Differences in placental structure during gestation associated with large and small pig fetuses[J].J Anim Sci,2007,85(12):3267-3275.
[87]	VALLET J L,MILES J R,FREKING B A,et al.Glucosamine supplementation during late gestation alters placental development and increases litter size[J].J Anim Sci Biotechnol,2017,8(1):68.
[88]	VALLET J L,MILES J R,FREKING B A.Effect of fetal size on fetal placental hyaluronan and hyaluronoglucosaminidases throughout gestation in the pig[J].Anim Reprod Sci,2010,118(2-4):297-309.
[89]	KAIDANOVICH-BEILIN O,WOODGETT J R.GSK-3:functional insights from cell biology and animal models[J].Front Mol Neurosci,2011,4:40.
[90]	PHUKAN S,BABU V S,KANNOJI A,et al.GSK3β:role in therapeutic landscape and development of modulators[J].Br J Pharmacol,2010,160(1):1-19.
[91]	PATEL P,WOODGETT J R.Glycogen synthase kinase 3:A kinase for all pathways?[J].Curr Top Dev Biol,2017,123:277-302.
[92]	YUAN D,YANG Z,CHEN Y Y,et al.Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway[J].Cell Biol Int,2021,45(3):599-611.
[93]	PLYTE S E,HUGHES K,NIKOLAKAKI E,et al.Glycogen synthase kinase-3:functions in oncogenesis and development[J].Biochim Biophys Acta (BBA)-Rev Cencer,1992,1114(2-3):147-162.
[94]	AKISON L K,NITERT M D,CLIFTON V L,et al.Review:alterations in placental glycogen deposition in complicated pregnancies:current preclinical and clinical evidence[J].Placenta,2017,54:52-58.
[95]	SHAFRIR E,BARASH V.Placental glycogen metabolism in diabetic pregnancy[J].Isr J Med Sci,1991,27(8-9):449-461.
[96]	GABBE S G,DEMERS L M,GREEP R O,et al.Placental glycogen metabolism in diabetes mellitus[J].Diabetes,1972, 21(12):1185-1191.
[97]	DESOYE G,KORGUN E T,GHAFFARI-TABRIZI N,et al.Is fetal macrosomia in adequately controlled diabetic women the result of a placental defect?-a hypothesis[J].J Matern Fetal Neonatal Med,2002,11(4):258-261.
[98]	DESBOIS-MOUTHON C,CADORET A,BLIVET-VAN EGGELPOËL M J,et al.Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation[J].Oncogene,2001,20(2):252-259.
[99]	POTZ B A,SABE A A,ELMADHUN N Y,et al.Glycogen synthase kinase 3β inhibition improves myocardial angiogenesis and perfusion in a swine model of metabolic syndrome[J].J Am Heart Assoc,2016,5(7):e003694.
[100]	YANG L J,ZHOU M,HUANG L B,et al.Zearalenone-promoted follicle growth through modulation of Wnt-1/β-catenin signaling pathway and expression of estrogen receptor genes in ovaries of postweaning piglets[J].J Agric Food Chem,2018,66(30):7899-7906.
[101]	WANG C X,CHEN F,ZHANG W F,et al.Leucine promotes the growth of fetal pigs by increasing protein synthesis through the mTOR signaling pathway in longissimus dorsi muscle at late gestation[J].J Agric Food Chem,2018,66(15):3840-3849.
[102]	LOUWAGIE E J,LARSEN T D,WACHAL A L,et al.Placental lipid processing in response to a maternal high-fat diet and diabetes in rats[J].Pediatr Res,2018,83(3):712-722.
[103]	HARDIE D G,ROSS F A,HAWLEY S A.AMPK:a nutrient and energy sensor that maintains energy homeostasis[J].Nat Rev Mol Cell Biol,2012,13(4):251-262.
[104]	HARDIE D G.AMP-activated/SNF1 protein kinases:conserved guardians of cellular energy[J].Nat Rev Mol Cell Biol,2007, 8(10):774-785.
[105]	SAKAMOTO K,MCCARTHY A,SMITH D,et al.Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction[J].EMBO J,2005,24(10):1810-1820.
[106]	SAKAMOTO K,ZARRINPASHNEH E,BUDAS G R,et al.Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1[J].Am J Physiol Endocrinol Metab,2006,290(5):E780-E788.
[107]	SUN C,TIAN L,NIE J,et al.Inactivation of MARK4,an AMP-activated protein kinase (AMPK)-related kinase,leads to insulin hypersensitivity and resistance to diet-induced obesity[J].J Biol Chem,2012,287(45):38305-38315.
[108]	TIAN L,XIE J L,DONG S S,et al.Maternal obesity stimulates lipotoxicity and up-regulates inflammatory signaling pathways in the full-term swine placenta[J].Anim Sci J,2018,89(9):1310-1322.
[109]	DENNIS P B,JAESCHKE A,SAITOH M,et al.Mammalian TOR:a homeostatic ATP sensor[J].Science,2001, 294(5544):1102-1105.
[110]	孟丹华,尚艺婉,武颖烁,等.基于AMPK/mTOR信号通路研究异常山碱对EC9706细胞能量代谢的调控机制[J].中草药,2020,51(17):4482-4488.MENG D H,SHANG Y W,WU Y S,et al.Isofebrifuzine regulates energy metabolism of EC9706 cells based on AMPK/mTOR signaling pathway[J].Chinese Traditional and Herbal Drugs,2020,51(17):4482-4488.(in Chinese)
[111]	HU C J,YANG Y Y,LI J Y,et al.Maternal diet-induced obesity compromises oxidative stress status and angiogenesis in the porcine placenta by upregulating Nox2 expression[J].Oxid Med Cell Longev,2019,2019:2481592.
[112]	TORRY D S,HINRICHS M,TORRY R J.Determinants of placental vascularity[J].Am J Reprod Immunol,2004,51(4):257-268.
[113]	BEE G.Effect of early gestation feeding,birth weight,and gender of progeny on muscle fiber characteristics of pigs at slaughter[J].J Anim Sci,2004,82(3):826-836.
[114]	JINDAL R,COSGROVE J R,AHERNE F X,et al.Effect of nutrition on embryonal mortality in gilts:Association with progesterone[J].J Anim Sci,1996,74(3):620-624.
[115]	CAMPOS P H R F,SILVA B A N,DONZELE J L,et al.Effects of sow nutrition during gestation on within-litter birth weight variation:A review[J].Animal,2012,6(5):797-806.
[116]	FUJII N,JESSEN N,GOODYEAR L J.AMP-activated protein kinase and the regulation of glucose transport[J].Am J Physiol Endocrinol Metab,2006,291(5):E867-E877.
[117]	TONG J F,YAN X,ZHU M J,et al.Maternal obesity downregulates myogenesis and β-catenin signaling in fetal skeletal muscle[J].Am J Physiol Endocrinol Metab,2009,296(4):E917-E924.
[118]	SABEN J,LINDSEY F,ZHONG Y,et al.Maternal obesity is associated with a lipotoxic placental environment[J].Placenta,2014, 35(3):171-177.
[119]	CACICEDO J M,BENJACHAREONWONG S,CHOU E,et al.Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes[J].Invest Ophthalmol Vis Sci,2011,52(6):3630-3639.
[120]	QI J Z,GONG J Y,ZHAO T J,et al.Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue[J].EMBO J,2008,27(11):1537-1548.
[121]	PENG T,GOLUB T R,SABATINI D M.The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation[J].Mol Cell Biol,2002,22(15):5575-5584.
[122]	GODFREY K M,MATTHEWS N,GLAZIER J,et al.Neutral amino acid uptake by the microvillous plasma membrane of the human placenta is inversely related to fetal size at birth in normal pregnancy[J].J Clin Endocrinol Metab,1998,83(9):3320-3326.
[123]	ROOS S,POWELL T L,JANSSON T.Placental mTOR links maternal nutrient availability to fetal growth[J].Biochem Soc Trans,2009,37(1):295-298.
[124]	JACINTO E,HALL M N.Tor signalling in bugs,brain and brawn[J].Nat Rev Mol Cell Biol,2003,4(2):117-126.
[125]	SURYAWAN A,DAVIS T A.Regulation of protein synthesis by amino acids in muscle of neonates[J].Front Biosci (Landmark Ed),2011,16:1445-1460.
[126]	WU G Y,BAZER F W,DAVIS T A,et al.Arginine metabolism and nutrition in growth,health and disease[J].Amino Acids,2009,37(1):153-168.
[127]	VOSATKA R,HASSOUN P M,HARVEY-WILKES K B.Dietary L-arginine prevents fetal growth restriction in rats[J].Am J Obst Gynecol,1998,178(2):242-246.
[128]	MATEO R D,WU G Y,BAZER F W,et al.Dietary L-arginine supplementation enhances the reproductive performance of gilts[J].J Nutr,2007,137(3):652-656.
[129]	XIAO X M,LI L P.L-Arginine treatment for asymmetric fetal growth restriction[J].Int J Gynaecol Obstet,2005,88(1):15-18.
[130]	KONG X F,TAN B,YIN Y L,et al.L-arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells[J].J Nutr Biochem,2012,23(9):1178-1183.
[131]	WU G Y.Amino acids:biochemistry and nutrition[M].CRC Press,2021.
[132]	KIM J Y,BURGHARDT R C,WU G Y,et al.Select nutrients in the ovine uterine lumen.VII.Effects of arginine, leucine, glutamine,and glucose on trophectoderm cell signaling,proliferation,and migration[J].Biol Reprod,2011,84(1):62-69.
[133]	WU G Y,BAZER F W,HU J B,et al.Polyamine synthesis from proline in the developing porcine placenta[J].Biol Reprod,2005, 72(4):842-850.
[134]	KONG X F,WANG X Q,YIN Y L,et al.Putrescine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells[J].Biol Reprod,2014,91(5):106.
[135]	GREER E L,DOWLATSHAHI D,BANKO M R,et al.An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans[J].Curr Biol,2007,17(19):1646-1656.
[136]	JI Y,WU Z L,DAI Z L,et al.Fetal and neonatal programming of postnatal growth and feed efficiency in swine[J].J Anim Sci Biotechnol,2017,8(1):42.
[137]	ELANGO R,BALL R O.Protein and amino acid requirements during pregnancy[J].Adv Nutr,2016,7(4):839S-844S.
[138]	ALTMANN S,MURANI E,SCHWERIN M,et al.Dietary protein restriction and excess of pregnant German Landrace sows induce changes in hepatic gene expression and promoter methylation of key metabolic genes in the offspring[J].J Nutr Biochem,2013,24(2):484-495.
[139]	WU G Y,BAZER F W,JOHNSON G A,et al.Functional amino acids in the development of the pig placenta[J].Mol Reprod Dev,2017,84(9):870-882.
[140]	KUCIA M,LANGHAMMER M,GÖRS S,et al.High-protein diet during gestation and lactation affects mammary gland mRNA abundance,milk composition and pre-weaning litter growth in mice[J].Animal,2011,5(2):268-277.
[141]	DINIZ W J S,REYNOLDS L P,BOROWICZ P P,et al.Maternal vitamin and mineral supplementation and rate of maternal weight gain affects placental expression of energy metabolism and transport-related genes[J].Genes (Basel),2021,12(3):385.
[142]	SRINIVAS V,MOLANGIRI A,MALLEPOGU A,et al.Maternal n-3 PUFA deficiency alters uterine artery remodeling and placental epigenome in the mice[J].J Nutr Biochem,2021,96:108784.
[143]	WISE T,ROBERTS A J,CHRISTENSON R K.Relationships of light and heavy fetuses to uterine position,placental weight,gestational age,and fetal cholesterol concentrations[J].J Anim Sci,1997,75(8):2197-2207.
[144]	CHE L,XU M M,YANG Z G,et al.Detection of placental proteomes at different uterine positions in large white and meishan gilts on gestational day 90[J].PLoS One,2016,11(12):e0167799.
[145]	WISE T H,CHRISTENSON R K.Relationship of fetal position within the uterus to fetal weight,placental weight,testosterone,estrogens,and thymosin β4 concentrations at 70 and 104 days of gestation in swine[J].J Anim Sci,1992,70(9):2787-2793.
[146]	王洁,马静萍.丁苯酞通过p53/mTOR通路对大鼠脑缺血再灌注损伤后自噬的影响[J].世界最新医学信息文摘,2018,18(43):19-21,26.WANG J,MA J P.The Effect of Butylphthalide through p53/mTOR pathway on autophagy after cerebral Ischemia-reperfusion injury in rats[J].World Latest Medicine Information,2018,18(43):19-21,26.(in Chinese)
[147]	GAO L M,ZHOU T T,CHEN Z P,et al.Maternal yeast-based nucleotide supplementation decreased stillbirth by regulating nutrient metabolism[J].J Sci Food Agric,2021,101(10):4018-4032.

Research Progress on Mammalian Placental Nutrition Sensing

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 147

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	DAI Fan, LIU Zhanyou, ZHANG Xuyang, LI Wu. Aconitate Decarboxylase 1 Could Regulate the Inflammatory Response Caused by BCG [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1696-1706.
[2]	BI Zhenwei, WANG Wenjie, LIU Yakun, PENG Daxin. Cloning of a New Canine ANP32A and Its Role in Cross-species Infection of Influenza Virus [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(2): 660-669.
[3]	XIAO Le, LIU Junyuan, ZENG Wenyu, WANG Qin, HAN Wenjue, LIU Yanling, FAN Yu, XU Yuting, YANG Beini, XIAO Xiong, WANG Zili. Microbiome and Transcriptome Analyses Revealed the Regulatory Mechanism of Xiangsha Liujunzi Decoction on Ileal Injury Induced by ETEC in Weaned Piglets with Diarrhea [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(2): 797-808.
[4]	TIAN Qihui, ZHANG Liang, LONG Yali. Study on the Effect of Astragalus on Proliferation of Bone Marrow Mesenchymal Stem Cells in Anoxic Microenvironment based on PI3K-AKT Signal Pathway [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 346-354.
[5]	HAN Kunliang, LAN Wei, HU Xin, CUI Yadong, KONG Xiangfeng. Effects of Compound Chinese Herb Ultrafine Powder on Antioxidant Ability and Related Gene Expression in Laying Hens [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(9): 3784-3792.
[6]	LI Yuexin, LIU Aiju, MA Xiaofei, ZHENG Zhong, HU Boxin, ZHI Yunxia, TIAN Shujun. Effect of TGFβR1 on the Function of Sheep Granulosa Cells Mediated by TGF-β/Smad Signaling Pathway [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3335-3347.
[7]	ZHANG Peng, WANG Mingxiu, JING Kemin, PENG Wei, TIAN Yuan, LI Yuqian, FU Changqi, SHU Shi, ZHONG Jincheng, CAI Xin. Abnormal Expression of FGFs/FGFRs and Their Mediated Signaling Pathway Genes Affect the Proliferative Activity of Undifferentiated Spermatogonia in Cattleyak [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2886-2897.
[8]	XU Tiantian, ZHANG Tongtong, WANG Meng, WANG Xin. Transcription Factor Foxq1 Affects the Proliferation of Hair Follicle Stem Cells in Cashmere Goats via WNT/β-catenin Signaling Pathway [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2653-2661.
[9]	CHEN Yongping, KOU Yuhong, JIAO Wenjing, HOU Xiaoyu, FAN Honggang. Effect of Coenzyme Q10 on LPS-induced Acute Lung Injury in Mice [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1730-1741.
[10]	ZHANG Chengcheng, SUN Jiahao, WANG Xiuling, ZHANG Xiaorong, WU Yantao. Beclin1 Interacts with the Nonstructural Protein NS5A of CSFV and Promotes Virus Proliferation [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 715-725.
[11]	REN Xiujuan, KANG Decuo, SU Shaofeng, LIN Yanan, LI Yajing, DU Ming, BAI Dongyi, LI Bei, ZHAO Yiping, DUGARJAVIIN Manglai. Comparison of Immune Gene Expression between Mongolian Horse and Thoroughbred [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5020-5032.
[12]	LUO Ju, MAO Jiani, XIA Yinzhao, YANG Zhenguo. Regulation of circRNAs on Mammalian Intestinal Barrier Function [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4439-4448.
[13]	ZHAO Yaya, CHANG Jiang, JU Ning, LUO Yulong. Mechanism of Plant Polyphenols Addition in Diet Regulating Meat Color Stability [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(1): 36-47.
[14]	LIU Lihua, ZHONG Zhenyu, ZHENG Yujie, WANG Xin. lncRNA EPB41L4A-AS Inhibits the Proliferation of Bovine Mammary Epithelial Cells by Regulating the Expression of ErbB3 Gene [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2152-2159.
[15]	LU Jiang, ZHU Daoxian, LIU Li, HAO Fuxing, WU Zhi, FU Hongqing. Artesunate Improves Acute Renal Injury in Dogs by Inhibiting Oxidative Stress Via Keap1/Nrf2 Signaling Pathway in vitro and in vivo [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2343-2353.