CRISPR/Cas9基因编辑技术在重要猪病毒病防控中的研究与应用

doi:10.11843/j.issn.0366-6964.2020.05.006

Abstract

Abstract: Clustered regularly interspaced short palindromic repeat (CRISPR) is an acquired immune system that exists widely in archaea and bacteria, mediated by RNA and assisted by Cas protein. It has been found that the CRISPR/Cas9 was the most widely used CRISPR system. This review mainly summarizes the basic principle and research progress of the CRISPR/Cas9 system, and highlights its application in the prevention and control of important swine virus diseases, including host modification and virus modification. This technology provides a powerful tool for the study of virus pathogenic mechanism, next generation vaccine development and disease resistance breeding. It has a far-reaching impact on the control of the diseases.

Key words: CRISPR/Cas9, prevention and control of swine disease, next generation vaccine, disease resistance breeding

CLC Number:

DAI Xueyu, ZHANG Qianyi, XU Lu, ZHAO Qizu, WANG Qin, XIA Yingju. Research Progress and Application of CRISPR/Cas9 Gene Editing Technology in Prevention and Control of Important Swine Virus Diseases[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(5): 943-951.

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Research Progress and Application of CRISPR/Cas9 Gene Editing Technology in Prevention and Control of Important Swine Virus Diseases

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