ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2017, Vol. 48 ›› Issue (11): 2023-2033.doi: 10.11843/j.issn.0366-6964.2017.11.003

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Research Progress of the Mainly Bacterial Efflux Pumps and Related Regulator

GAO Hai-jiao, CHENG Gu-yue, WANG Yu-lian, NING Jia-nan, CHEN Ting, LI Jun, HAO Hai-hong*, YUAN Zong-hui*   

  1. National Reference Laboratory of Veterinary Drug Residue(HZAU), Key Laboratory for the Detection of Veterinary Drug Residue in Food of Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China
  • Received:2017-05-31 Online:2017-11-23 Published:2017-11-23

Abstract:

Multidrug efflux pumps are found in any organism and constitute a series of transporters, which contribute to the resistant to antibiotics intrinsic and acquired. Nowadays, numerous efflux pump-related proteins have been investigated, and the exact mechanism of induction drug extrusion is researching. Also, there are few efflux-related protein used in antibiotic residue detection. The aim of this review is to elucidate the types of efflux pumps and their constitutive and regulator proteins, and also the application of efflux pump proteins in antibiotic residue detection. Finally, the problems and developmental trends in the research of efflux pump are summarized and discussed.

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