天鹅源丙型副伤寒沙门菌感染实验小鼠的组织病理学及抗原分布

doi:doi: 10.11843/j.issn.0366-6964.2016.08.018

Abstract

Abstract:

To learn histopathology of the mice infected with Salmonella ParatyphiC，clarify antigen distribution in tissue of the mice，and lay the groundwork of pathogenic mechanism，mice were infected with Salmonella Paratyphi C by drench.After being infected，11 tissues of the mice were sampled，embedded in paraffin，and dyed by HE and immune enzymatic technique.Three to six hours post challenge，inflammatory reaction were observed in heart，liver，spleen，lung, kidney，intestinal tract and brain，and lasted until 14 d post challenge.Necrosis，fall-off and inflammatory injury occurred in ileum，thrombus were found in ventriculus dexter.Alveolar walls were thickened，and vascular congestion，edema and inflammatory cells infiltration were observed.Chronic fibrous pneumonia，alveobronchiolitis，acute glomerulonephritis，and denaturation，necrosis，inflammatory injury and typhoid nodule in several organs were observed.Three hours after being challenged，antigen was detected in the sampled organs except brain.Besides extremely high quantity of antigen in the intestinal tract (infection route)，the strongest positive signal were also detected in spleen，heart，lung and liver，which mainly existed in cytoplasm of the tissues.These results indicate that Salmonella Paratyphi C separated from swan can infect mice，encroach many organs of mice，and lead to denaturation，necrosis and inflammatory injury in the organs to different extent in long time.

CLC Number:

S852.612

LUO Wei，RAN Dan-dan，CHEN Dong-ping，LIU Qun. Histopathology and Antigen Distribution in the Mice Infected with Salmonella Paratyphi C Separated from Swan[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(8): 1667-1675.

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Histopathology and Antigen Distribution in the Mice Infected with Salmonella Paratyphi C Separated from Swan

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