鸡白痢沙门菌分离株的致病性分析

doi:10.11843/j.issn.0366-6964.2013.11.016

Abstract

Abstract:

To investigate the pathogenicity of Salmonella pullorum (S. pullorum) to young chickens, fatal infection experiment was conducted in young chickens by inoculating 12 S. Pullorum, which were chosen from 78 S. pullorum isolates in Eastern China during 2010 and 2012. LD₅₀ and colonization of two virulent S. pullorum isolates was tested in young chickens, while histopathology and immunohistochemistry were applied to analyze pathological lesions and distribution of S. pullorum in tissues at different time point. Results were as follows: Lesions early appeared in tissues at day 3 after inoculation; The most serious lesions appeared during day 7 and 14, and decreased obviously after day 21. The quantity of S. pullorum colonization in different tissues varied during the infection. The two S. pullorum isolates were high pathogenic to young chickens, and different isolates had different ability of colonization and distribution in tissues. This research provided experimental evidence for analyzing the mechanisms and developing vaccine of S. pullorum.

CLC Number:

S852.612

ZHA Hua, SHI Huo-ying, JI Zhen-ying, SHANG Jing, JIN Hai-yun, LIU Yi, WANG Wan. Pathogenic Analysis of Salmonella pullorum[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(11): 1812-1818.

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Pathogenic Analysis of Salmonella pullorum

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