传染性法氏囊病毒对SPF雏鸡免疫器官细胞凋亡及bcl-2 mRNA表达的影响

Abstract

Abstract:

Apoptosis and expression of bcl-2 mRNA in the immune organs of chicks infected with infectious bursal disease virus (IBDV) were investigated. The number of apoptosis cells was assessed by TUNEL method. The expression of bcl-2 mRNA was investigated by Real-time PCR. The results showed that the apoptosis cells in bursa of Fabricius, thymus and s pleen of chicks infected with IBDV from the third to seventh day post infection are significant or extremely significant higher than that of normal SPF chicks (P<0.01 or P<0.05).At the same time, the expression of bcl-2 mRNA significantly increased in the immune organs of SPF chicks infected with IBDV from the third to seventh day post infection compared with those of normal chicks (P<0.01 or P<0.05). These study indicates that IBDV can improve the number of apoptosis and the expression of bcl-2 mRNA in immune organs of chicks infected with IBDV.

CLC Number:

S858.315.3

TONG Mei-jiao, GAO Xue-li, LI Bo-tao, ZHENG Shi-min. The Apoptosis and Expression of bcl-2 mRNA in the Immune Organs of SPFChicks Infected with Infectious Bursal Disease Virus[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, doi: .

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References

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The Apoptosis and Expression of bcl-2 mRNA in the Immune Organs of SPFChicks Infected with Infectious Bursal Disease Virus

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