Acta Veterinaria et Zootechnica Sinica ›› 2025, Vol. 56 ›› Issue (6): 2948-2956.doi: 10.11843/j.issn.0366-6964.2025.06.037

• Basic Veterinary Medicine • Previous Articles     Next Articles

Pathological and Immunohistochemical Analysis of A Case of Feline Nasal Malignant Neuroendocrine Neoplasm

ZHENG Yilei1,2(), SHEN Fengting1,2(), XIN Liang1, YUAN Xiwang1, LIN Lin3, CAO Di3, WU Jiusheng1,2, SHI Fushan1,2, WANG Huanan1,2,*()   

  1. 1. Veterinary Teaching Hospital, Center for Veterinary Sciences, Zhejiang University, Hangzhou 310030, China
    2. Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310030, China
    3. MetaHealth Veterinary Diagnostic Laboratory, Hangzhou 310059, China
  • Received:2024-07-23 Online:2025-06-23 Published:2025-06-25
  • Contact: WANG Huanan E-mail:yileizheng@zju.edu.cn;22317101@zju.edu.cn;hnwang@zju.edu.cn

Abstract:

The purpose of this article is to report the pathologic and immunohistochemical features of a case of feline nasal malignant neuroendocrine neoplasm. A 4-year-old male British shorthair cat was referred to our hospital after being treated for pneumonia for one month. A nasal mass was found on examination, and a surgical biopsy was performed to remove the nasal mass for histopathological and immunohistochemical examination. A biopsy of the nasal mass was performed for histopathological and immunohistochemical examination. Histopathological findings indicate that the tumor cells exhibit significant variability in size and shape, with marked atypia. The nuclei are predominantly vesicular, and the tumor has invaded surrounding tissues. Immunohistochemical results show positive staining for neuron-specific enolase (NSE), synaptophysin (Syn), vasoactive intestinal peptide (VIP), and CD99 (cluster of differentiation 99, CD99). Based on laboratory tests, histopathology and immunohistochemistry, the final diagnosis was nasal malignant neuroendocrine neoplasm and more inclined to poorly differentiated neuroendocrine carcinoma (NEC). This case hoping to provide a reference for diagnosing this tumor and differentiating it from other nasal cavity tumors.

Key words: cat, neuroendocrine neoplasm, histopathology, immunohistochemistry

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