猪流行性腹泻病毒的天然免疫逃避机制及其防控研究进展

doi:10.11843/j.issn.0366-6964.2025.06.006

Abstract

Abstract:

Porcine epidemic diarrhea (PED) is an acute, highly contagious intestinal infectious disease caused by porcine epidemic diarrhea virus (PEDV), characterized primarily by vomiting, dehydration, and diarrhea. In recent years, the emergence of variant PEDV strains has led to significant economic losses in the pig farming industry in many countries. Therefore, investigating the pathogenic mechanisms of PEDV and identifying effective prevention and control measures are essential to ensuring the health and productivity of pig farming. This review summarizes the mechanisms by which PEDV evades host immune responses, including the inhibition of interferon production and the regulation of apoptosis, autophagy, pyroptosis, and inflammatory responses. Additionally, it discusses the progress in vaccine development and nutritional interventions aimed at controlling PEDV, providing a theoretical foundation for the effective control of PED.

Key words: porcine epidemic diarrhea virus, escape mechanism, prevention and control measures

CLC Number:

S852.65

WU Chao, MING Wenhan, LU Shuwan, YANG Caimei, LIU Jinsong, MA Xiang, ZHANG Ruiqiang. Innate Immune Evasion Mechanisms of Porcine Epidemic Diarrhea Virus and Advances in Prevention and Control Strategies[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(6): 2590-2599.

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Innate Immune Evasion Mechanisms of Porcine Epidemic Diarrhea Virus and Advances in Prevention and Control Strategies

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