动物源细菌耐药性及中药消减耐药性的研究进展

doi:10.11843/j.issn.0366-6964.2025.06.004

Abstract

Abstract:

The addition of antibiotics to animal feed has reduced the occurrence of animal diseases in livestock and poultry production and promoted growth. However, it also leads to a series of problem including antibiotic residues in animal-derived products and the environment, an increase in multi-drug resistant bacteria in animals, etc. And also has a serious impact on food safety and the development of animal husbandry, which threatening human health and the ecological environment. Against the backdrop of the national policy of "banning antibiotics in feed and reducing their use in breeding", the use of alternative products that can enhance the disease resistance of animals has become a research hotspot. Among them, traditional Chinese medicine has received widespread attention due to its wide sources, few side effects, and low likelihood of developing drug resistance. When used alone or in combination with antibacterial drugs, it shows good antibacterial effects. This article discusses the current situation of antibiotic resistance in animal-derived bacteria in China and reviews traditional Chinese medicines that can reduce antibiotic resistance in animal-derived bacteria and their mechanisms of action, with the aim of providing a scientific basis for in-depth research and control of antibiotic resistance in animal-derived bacteria.

Key words: animal-derived bacteria, antimicrobial resistance, traditional Chinese medicine, elimination

CLC Number:

S856
S853

LI Wenchao, LI Weiqiao, LI Xin, WANG Jiaqing, ZHANG Yawei, LI Junping. Research Progress on Antimicrobial Resistance of Animal-derived Bacteria and Elimination of Antimicrobial Resistance by Traditional Chinese Medicine[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(6): 2555-2576.

Figures/Tables 3

Table 1

Table 2

Prevalence of animal-derived ARGs in some areas of China"

年份 Year	区域 Region	来源 Provenance	基因 Gene	耐药菌阳性率(基因检出率) Antimicrobial resistance gene prevalence (gene detection rate)	参考文献 References
2015	山东	猪	bla_CTX-M-55、bla_CTX-M-14、bla_CTX-M-15	56.7%(32.4%、29.4%、20.6%)	^[41]
2014—2016	福建	猪	bla_CTX-M-14、bla_CT-M-65、bla_CTX-M-55	32.7%(18.0%、12.1%、7.5%)	[42]
2015—2017	陕西和甘肃	猪	bla_CTX-M-14、 bla_CTX-M-15	9.6%(52.3%、34.1%)	[43]
2017—2018	青海和甘肃	鸡、犬、猪、牦牛	TEM、CTM、SHV	55.5%患病；健康5.6%(82.3%、43.5%、19.4%)	[44]
2016—2021	湖南	鸡、猪、牛	bla_CTX-M-55	6.66%(42.9%)	[45]
2008—2014	上海、山西、四川、山东	鸡	bla_CTX-M-55、bla_CTX-M-65、bla_TEM	34.3%、17.9%、86.0%	[46]
2014—2015	山东	鸡	bla_CTX-M、bla_TEM-1、bla_SHV-5、	88.8%(100%、74.65%、3.52%)	[47]
2015—2019	广东、山东、新疆、黑龙江	鸡	bla_TEM、bla_CTX-M和bla_OXA	78.6%(100%、74.6%和3.64%)	[40]
2019	山西	鸡	bla_TEM、bla_OXA和bla_CTX-M-1/9	83.8%(93.33%、53.33%、86.67%)	[48]
2021	山东	禽	bla_CTX-M-55、bla_NDM-5、bla_NDM-4	3.5%(34.2%、66.7%、33.3%)	[49]
2015—2017	中国16省	牛(奶)	bla_CTX-M-1₅	19.7%	[50]
2019—2020	宁夏、陕西、青海、内蒙	羊	bla_CTX-M-55、bla_CTX-M-15	13.4%(61.5%、19.2%)	[51]
2013—2015	陕西	犬	bla_TEM-1、bla_SHV-12、bla_CTX-M-15、bla_CTX-M-123	24.2%(77.5%、35%、77.5%、35%)	[52]
2014	广州	犬、猫	bla_CTX-M	23.2(100%)	[53]
2012—2017	北京	犬、猫	bla_CTX-M-65、bla_CTX-M-15和bla_NDM	34.65%(43.18%、40.91%)和2.36%	[54]
2009—2014	—	鸡	mcr-1	5.2%~30%	[56]
2015	山东	鸡	bla_NDM、mcr-1	43.6%、67.9%	[57]
2014—2015	中国24省	猪、禽	mcr-4；mcr-5	41.4%、11.5%；33.1%、5.6%	[58]
2016	中国9省	猪、鸡	mcr-1；mcr-2；mcr-3	79.2%、31.8%；56.3%、5.5%；0.5%~18.7%、5.2%	[59]
2016—2017	哈尔滨、长春、沈阳	猪	mcr-1	59.66%(53.33%)	[61]
2017	四川	猪	mcr-1.1	86.4%→5.6%	[62]
2016—2018	中国14省	猪	mcr-1	45%→19%	[63]
2018	广西	猪	mcr-1	23.24%	[64]
2019	河南	鸡	mcr-1	2.62%	[65]
2019—2020	安徽、河南、辽宁等7省	猪、鸡	mcr-1	0.93%	[66]
2020	浙江	猪、鸡	mcr-1	1.36%(61.11%)	[15]
2015	北京	犬、猫	mcr-1	7.4%	[67]
2016	广州	犬、猫	mcr-1	6.25%	[68]
2013—2017	安徽	鸡	bla_NDM-7、bla_NDM-5	0.25%、1.25%	[72]
2018	安徽	鸭	bla_NDM	57.8%	[73]
2015	四川	猪	bla_NDM-5和mcr-1	15.2%	[74]
2015	哈尔滨、扬州、重庆、武汉、成都、广州	犬、猫	bla_NDM-5	4.7%	[75]

Table 2

Table 3

The elimination effect of effective components of traditional Chinese medicine on drug resistance of animal-derived bacteria"

消减机制 Elimination mechanism	中药成分 Herbal constituent	抗菌谱 Antimicrobial spectrum	作用方式 Mechanism of action	参考文献 References
抑制细菌耐药酶 Inhibit bacterial drug-resistant enzymes	丁香油和罗勒叶	禽源ESBL大肠杆菌	抑制β-内酰胺酶活性	[93]
	芦荟大黄素、苦参碱、香紫苏醇、木犀草素、槲皮素、五味子甲素、大蒜素	猪源ESBL大肠杆菌	抑制β-内酰胺酶活性	[94]
	异甘草素	多黏菌素耐药和碳青霉烯类耐药大肠杆菌	抑制NDM-1的水解活性，并显著增加美罗培南对NDM-1阳性菌的抗菌活性	[95]
改变细胞膜通透性Alter cell membrane permeability	肉桂醛	产ESBL、耐喹诺酮类大肠杆菌	提高孔蛋白基因转录水平，从而提高细菌细胞膜渗透性，促进抗生素流入细胞内	[96]
改变细胞膜通透性Alter cell membrane permeability	槲皮素	耐碳青霉烯类大肠杆菌和肺炎克雷伯菌	与美罗培南协同作用破坏细胞壁/膜完整性和改变细胞形态	[97]
抑制生物被膜形成 Inhibit biofilm formation	小檗碱和苦参碱	多重耐药大肠杆菌	降低细菌群体感应系统(quorum sensing，QS)相关基因: luxS、pfS、sdiA、hflX、motA和fliA的表达	[98]
	黄芩苷	碳青霉烯抗性铜绿假单胞菌	与妥布霉素协同作用使生物膜相关基因 algD、pslA和lasR显著下调	[99]
		禽源多重耐药大肠杆菌	减少主要细菌黏附因子AI-2的分泌，干扰QS系统和生物被膜形成	[100]
	茶多酚	多重耐药肺炎克雷伯菌	与亚胺培南、哌拉西林等抗生素协同杀菌，影响细菌外膜形成和胞外黏液样物质产生	[101]
抑制主动外排泵 Inhibit active efflux pumps	小檗碱	多重耐药金黄色葡萄球菌	结合NorA和RamR外排泵，抑制细菌甚至Mtb的生长	[103]
	盐酸小檗碱	多重耐药鲍曼不动杆菌	占据外排蛋白的结合位点，减少抗生素从外排泵排出	[104]
	槲皮素	多重耐药大肠杆菌	与大肠杆菌EmrE外排泵稳定结合	[105]
	芍药苷	多重耐药大肠杆菌	作用外排泵转运子AcrB，抑制细菌外排泵活性，阻滞尼罗红的外排	[88]
	甘草酸	禽源多重耐药大肠杆菌	与细菌产生的多药外排泵蛋白AcrB相互作用，抑制其多药外排泵的外排活性；也可促进细菌中AcrR、 MarR负调控因子的表达，进而减少AcrB产量，影响菌体形成的多药外排泵数量	[107]
消除耐药质粒 Eliminate drug-resistant plasmids	山楂水提物	耐β-内酰胺类大肠杆菌	使细菌的质粒条带减少1~3条	[109]
	大叶桉	耐甲氧西林金黄色葡萄球菌	明显抑制MRSA生长，24、48 h质粒消除率分别为38.6%和62.0%	[110]
	小檗碱	多重耐药大肠杆菌	使细菌的质粒条带减少1~2条；ESBLs活性降低，碱性磷酸酶活性升高；外排系统AcrA mRNA转录水平极显著降低	[82]
	石榴叶提取物	耐青霉素大肠杆菌和耐青霉素金黄色葡萄球菌	联合阿莫西林增加大肠杆菌细胞通透性、抑制青霉素酶活性和葡萄球菌生物膜形成	[111]

Table 3

References 111

1	MULCHANDANI R , WANG Y , GILBERT M , et al. Global trends in antimicrobial use in food-producing animals: 2020 to 2030[J]. PLOS Glob Public Health, 2023, 3 (2): e0001305. doi: 10.1371/journal.pgph.0001305
2	中华人民共和国农业农村部. 2020年中国兽用抗菌药使用情况报告[J]. 兽医公报, 2021, 23 (9): 33- 36.
	Ministry of Agriculture and Rural Affairs of People's Republic of China . 2020 Annual report on the use of veterinary antibiotics in China[J]. Official Veterinary Bulletin, 2021, 23 (9): 33- 36.
3	Antimicrobial Resistance Collaborators . Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis[J]. Lancet, 2022, 399 (10325): 629- 655. doi: 10.1016/S0140-6736(21)02724-0
4	农业农村部. 中华人民共和国农业农村部公告第194号[EB/OL]. (2020-02-17)[2024-08-18]. http://www.fgs.moa.gov.cn/flfg/202002/t20200217_6337167.htm.
	Ministry of Agriculture and Rural Affairs, PRC. Announcement of the Ministry of Agriculture and Rural Affairs of the People's Republic of China No. 194[EB/OL]. (2020-02-17)[2024-08-18]. http://www.fgs.moa.gov.cn/flfg/202002/t20200217_6337167.htm. (in Chinese)
5	农业农村部. 农业农村部关于印发《全国兽用抗菌药使用减量化行动方案(2021—2025年)》的通知: 农牧发〔2021〕31号. [EB/OL]. (2021-10-25)[2024-08-18]. http://www.moa.gov.cn/govpublic/xmsyj/202110/t20211025_6380448.htm.
	Ministry of Agriculture and Rural Affairs, PRC. Ministry of Agriculture and Rural Affairs Circular on Issuing the 《National Action Plan for Reducing the Use of Antimicrobial Agents in Animal Husbandry (2021-2025)》: Agricultural and Animal Husbandry Development [2021]No. 31. [EB/OL]. (2021-10-25)[2024-08-18]. http://www.moa.gov.cn/govpublic/xmsyj/202110/t20211025_6380448.htm. (in Chinese)
6	沈建忠. 动物源细菌耐药性与控制[M]. 北京: 科学出版社, 2024.
	SHEN J Z . Drug resistance and control of animal-derived bacteria[M]. Beijing: China Science Publishing & Media Ltd., 2024.
7	蒋月, 盛鹏飞, 张秀英. 辽宁锦州地区家禽大肠埃希菌耐药性研究[J]. 动物医学进展, 2013, 34 (11): 85- 88. doi: 10.3969/j.issn.1007-5038.2013.11.020
	JANG Y , SHENG P F , ZHANG X Y , et al. Study on antimicrobial resistance to Escherichia coli isolated from three different poultries[J]. Progress in Veterinary Medicine, 2013, 34 (11): 85- 88. doi: 10.3969/j.issn.1007-5038.2013.11.020
8	贡嘎, 王刚, 拉珍, 等. 西藏牦牛大肠杆菌对常用抗菌药物的耐药性分析[J]. 中国兽医杂志, 2014, 50 (8): 80- 82. doi: 10.3969/j.issn.0529-6005.2014.08.030
	GONG G , WANG G , LA Z , et al. Study on antiblotic resistance of yak E. coli[J]. Chinese Journal of Veterinary Medicine, 2014, 50 (8): 80- 82. doi: 10.3969/j.issn.0529-6005.2014.08.030
9	植婵萍, 郭小婷, 姚旭, 等. 有机农场鸡、猪源大肠杆菌耐药性研究[J]. 中国畜牧兽医, 2015, 42 (12): 3351- 3357.
	ZHL C P , GUO X T , YAO X , et al. Study on drug resistance of Escherichia coli lsolated from chicken and swine in organic farm[J]. China Animal Husbandry & Veterinary Medicine, 2015, 42 (12): 3351- 3357.
10	LU X Y , ZHANG P , DU P C , et al. Prevalence and genomic characteristics of mcr-positive Escherichia coli strains isolated from humans, pigs, and foods in China[J]. Microbiol Spectr, 2023, 11 (3): e0456922. doi: 10.1128/spectrum.04569-22
11	ZOU M , MA P P , LIU W S , et al. Prevalence and antibiotic resistance characteristics of extraintestinal pathogenic Escherichia coli among healthy chickens from farms and live poultry markets in China[J]. Animals (Basel), 2021, 11 (4): 1112.
12	高海慧, 王建东, 高小斐, 等. 奶牛犊牛腹泻源大肠埃希氏菌耐药情况及LEE相关基因的检测[J]. 动物医学进展, 2021, 42 (6): 19- 23. doi: 10.3969/j.issn.1007-5038.2021.06.004
	GAO H H , WANG J D , GAO X F , et al. Drug resistance of Escherichia coli in calves with dairy cows and detection of LEE-related genes[J]. Progress in Veterinary Medicine, 2021, 42 (6): 19- 23. doi: 10.3969/j.issn.1007-5038.2021.06.004
13	PENG Z , HU Z Z , LI Z G , et al. Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China[J]. Nat Commun, 2022, 13 (1): 1116. doi: 10.1038/s41467-022-28750-6
14	ZHANG X P , LI X X , WANG W H , et al. Diverse gene cassette arrays prevail in commensal Escherichia coli from intensive farming swine in four provinces of China[J]. Front Microbiol, 2020, 11, 565349. doi: 10.3389/fmicb.2020.565349
15	MA J G , ZHOU W , WU J , et al. Large-scale studies on antimicrobial resistance and molecular characterization of Escherichia coli from food animals in developed areas of Eastern China[J]. Microbiol Spectr, 2022, 10 (4): e0201522. doi: 10.1128/spectrum.02015-22
16	ZHANG S Q , SHU Y X , WANG Y W , et al. High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China[J]. Poult Sci, 2023, 102 (10): 102956. doi: 10.1016/j.psj.2023.102956
17	ZHANG P , SHEN Z Q , ZHANG C P , et al. Surveillance of antimicrobial resistance among Escherichia coli from chicken and swine, China, 2008-2015[J]. Vet Microbiol, 2017, 203, 49- 55. doi: 10.1016/j.vetmic.2017.02.008
18	DU Z , WANG M Y , CUI G Y , et al. The prevalence of amphenicol resistance in Escherichia coli isolated from pigs in mainland China from 2000 to 2018: A systematic review and meta-analysis[J]. PLoS One, 2020, 15 (2): e0228388. doi: 10.1371/journal.pone.0228388
19	秦春芝, 徐怀英, 黄迪海, 等. 山东省禽源致病性大肠杆菌流行病学监测及耐药模式分析[J]. 中国动物检疫, 2021, 38 (8): 16-21, 62. doi: 10.3969/j.issn.1005-944X.2021.08.005
	QIN C Z , XU H Y , HUANG D H , et al. Epidemiological surveillance of Avian pathogenic Escherichia coli in Shandong province and it's antimicrobial resistance analysis[J]. China Animal Health Inspection, 2021, 38 (8): 16-21, 62. doi: 10.3969/j.issn.1005-944X.2021.08.005
20	HARADA K , ASAI T , KOJIMA A , et al. Role of coresistance in the development of resistance to chloramphenicol in Escherichia coli isolated from sick cattle and pigs[J]. Am J Vet Res, 2006, 67 (2): 230- 235. doi: 10.2460/ajvr.67.2.230
21	SCHWARZ S , KEHRENBERG C , DOUBLET B , et al. Molecular basis of bacterial resistance to chloramphenicol and florfenicol[J]. FEMS Microbiol Rev, 2004, 28 (5): 519- 542. doi: 10.1016/j.femsre.2004.04.001
22	LIU H , WANG Y , WU C , et al. A novel phenicol exporter gene, fexB, found in enterococci of animal origin[J]. J Antimicrob Chemother, 2012, 67 (2): 322- 325. doi: 10.1093/jac/dkr481
23	LONG K S , POEHLSGAARD J , KEHRENBERG C , et al. The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics[J]. Antimicrob Agents Chemother, 2006, 50 (7): 2500- 2505. doi: 10.1128/AAC.00131-06
24	WANG Y , XU C Y , ZHANG R , et al. Changes in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: an epidemiological comparative study[J]. Lancet Infect Dis, 2020, 20 (10): 1161- 1171. doi: 10.1016/S1473-3099(20)30149-3
25	杨润时. 动物源肠杆菌中碳青霉烯耐药基因bla_NDM的流行分布及分子传播机制研究[D]. 广州: 华南农业大学, 2019.
	YANG R S. Dissemination and molecular transmission mechanism of carbapenem resistance gene bla_NDM in Enterobacteriaceae from animal origin[D]. Guangzhou: South China Agricultural University, 2019. (in Chinese)
26	LIU H , PAN S L , CHENG Y H , et al. Distribution and associations for antimicrobial resistance and antibiotic resistance genes of Escherichia coli from musk deer (Moschus berezovskii) in Sichuan, China[J]. PLoS One, 2023, 18 (11): e0289028. doi: 10.1371/journal.pone.0289028
27	YUAN Y , HU Y , ZHANG X L , et al. Characteristics of MDR E. coli strains isolated from Pet Dogs with clinic diarrhea: A pool of antibiotic resistance genes and virulence-associated genes[J]. PLoS One, 2024, 19 (2): e0298053. doi: 10.1371/journal.pone.0298053
28	李孟. 河南省猪源大肠杆菌耐药性调查及部分耐药基因分布特征研究[D]. 郑州: 河南农业大学, 2019.
	LI M. Drug resistance and distribution characteristics of some drug-resistant genes in Escherichia coli isolated from pigs in Henan province[D]. Zhengzhou: Henan Agricultural University, 2019. (in Chinese)
29	PENG J J , BALASUBRAMANIAN B , MING Y Y , et al. Identification of antimicrobial resistance genes and drug resistance analysis of Escherichia coli in the animal farm environment[J]. J Infect Public Health, 2021, 14 (12): 1788- 1795. doi: 10.1016/j.jiph.2021.10.025
30	LAI J , WU C M , WU C B , et al. Serotype distribution and antibiotic resistance of Salmonella in food-producing animals in Shandong province of China, 2009 and 2012[J]. Int J Food Microbiol, 2014, 180, 30- 38. doi: 10.1016/j.ijfoodmicro.2014.03.030
31	CAO T T , DENG G H , FANG L X , et al. Characterization of quinolone resistance in Salmonella enterica from farm animals in China[J]. J Food Prot, 2017, 80 (10): 1742- 1748. doi: 10.4315/0362-028X.JFP-17-068
32	ZHAO X N , HU M , ZHANG Q , et al. Characterization of integrons and antimicrobial resistance in Salmonella from broilers in Shandong, China[J]. Poult Sci, 2020, 99 (12): 7046- 7054. doi: 10.1016/j.psj.2020.09.071
33	王喜, 李珂, 李廷翠, 等. 75株蛋鸡源沙门菌的MLST分型与耐药性分析[J]. 畜牧兽医学报, 2022, 53 (5): 1626- 1631. doi: 10.11843/j.issn.0366-6964.2022.05.030
	WANG X , LI K , LI T C , et al. MLST typing and antimicrobial resistance analysis of 75 Salmonella strains isolated from laying hens[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 53 (5): 1626- 1631. doi: 10.11843/j.issn.0366-6964.2022.05.030
34	杨胜男, 王娟, 郑增忍, 等. 动物源空肠弯曲杆菌的分离及耐药性试验[J]. 动物医学进展, 2013, 34 (8): 116- 119. doi: 10.3969/j.issn.1007-5038.2013.08.024
	YANG S N , WANG J , ZHEN Z R , et al. Isolation and drug-resistence test of Campylobacter jejuni from anima source[J]. Progress in Veterinary Medicine, 2013, 34 (8): 116- 119. doi: 10.3969/j.issn.1007-5038.2013.08.024
35	张小燕, 周倩, 唐梦君, 等. 江苏地区鸡源弯曲杆菌分离鉴定及耐药性研究[J]. 中国家禽, 2017, 39 (18): 23- 27.
	ZHANG X Y , ZHOU Q , TANG M J , et al. Isolation, identification and antimicrobial susceptibility profiles of Campylobacter isolates from chickens in Jiangsu Province[J]. China Poultry, 2017, 39 (18): 23- 27.
36	唐梦君, 周倩, 张小燕, 等. 江苏部分地区鸡源与猪源弯曲菌耐药性分析与毒力基因检测[J]. 畜牧兽医学报, 2020, 51 (9): 2284- 2292.
	TANG M J , ZHOU Q , ZHANG X Y , et al. Antimicrobial resistance and virulence gene detection of Campylobacter strains isolated from chickens and pigs in Jiangsu Province[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51 (09): 2284- 2292.
37	YANG H L , LI Y B , ZHANG Y , et al. Prevalence, drug resistance spectrum and virulence gene analysis of Campylobacter jejuni in broiler farms in central Shanxi, China[J]. Poult Sci, 2023, 102 (3): 102419. doi: 10.1016/j.psj.2022.102419
38	YANG L , SHEN Y B , JIANG J Y , et al. Distinct increase in antimicrobial resistance genes among Escherichia coli during 50 years of antimicrobial use in livestock production in China[J]. Nat Food, 2022, 3 (3): 197- 205. doi: 10.1038/s43016-022-00470-6
39	SHI X M , LI Y M , YANG Y Y , et al. High prevalence and persistence of carbapenem and colistin resistance in livestock farm environments in China[J]. J Hazard Mater, 2021, 406, 124298. doi: 10.1016/j.jhazmat.2020.124298
40	LIU Z H , WANG K , ZHANG Y R , et al. High prevalence and diversity characteristics of bla_NDM, mcr, and bla_ESBLs harboring multidrug-resistant Escherichia coli from chicken, pig, and cattle in China[J]. Front Cell Infect Microbiol, 2021, 11, 755545.
41	ZHANG H N , ZHAI Z Z , LI Q , et al. Characterization of extended-spectrum β-lactamase-producing Escherichia coli isolates from pigs and farm workers[J]. J Food Prot, 2016, 79 (9): 1630- 1634. doi: 10.4315/0362-028X.JFP-16-093
42	杨守深, 曾雪花, 林敏, 等. 猪源大肠杆菌耐药性及超广谱β-内酰胺酶流行性分析[J]. 中国人兽共患病学报, 2019, 35 (1): 45- 50.
	YANG S S , ZENG X H , LIN M , et al. Antimicrobial resistance analysis and extended-spectrum-β-lactamaeses genes detection in Escherichia coli isolated from swine[J]. Chinese Journal of Zoonoses, 2019, 35 (1): 45- 50.
43	LIU X Q , LIU H X , WANG L , et al. Molecular characterization of extended-spectrum β-lactamase-producing multidrug resistant Escherichia coli from swine in Northwest China[J]. Front Microbiol, 2018, 9, 1756. doi: 10.3389/fmicb.2018.01756
44	WANG Y N , ZHOU J H , LI X R , et al. Genetic diversity, antimicrobial resistance and extended-spectrum β-lactamase type of Escherichia coli isolates from chicken, dog, pig and yak in Gansu and Qinghai Provinces, China[J]. J Glob Antimicrob Resist, 2020, 22, 726- 732. doi: 10.1016/j.jgar.2020.06.028
45	XIAO N , LI Y J , LIN H G , et al. Characterization of rxtended-dpectrum β-lactamase-producing Escherichia coli in animal farms in Hunan Province, China[J]. Microorganisms, 2024, 12 (4): 653. doi: 10.3390/microorganisms12040653
46	WU C M , WANG Y C , SHI X M , et al. Rapid rise of the ESBL and mcr-1 genes in Escherichia coli of chicken origin in China, 2008-2014[J]. Emerg Microbes Infect, 2018, 7 (1): 30.
47	LI S , ZHAO M M , LIU J H , et al. Prevalence and antibiotic resistance profiles of extended-spectrum β-lactamase-producing Escherichia coli isolated from healthy broilers in Shandong Province, China[J]. J Food Prot, 2016, 79 (7): 1169- 1173. doi: 10.4315/0362-028X.JFP-16-025
48	马馨, 刘一飞, 王志宇, 等. 鸡源大肠杆菌分离鉴定及ESBLs与AmpC酶基因型检测及耐药性分析[J]. 中国畜牧兽医, 2019, 46 (9): 2715- 2725.
	MA X , LIU Y F , WANG Z Y , et al. Isolation, identification, detection of ESBLs and AmpC enzyme genotypes and drug resistance analysis of Escherichia coli from chicken[J]. China Animal Husbandry & Veterinary Medicine, 2019, 46 (9): 2715- 2725.
49	宋祥彬, 赵晓雨, 李传溥, 等. 山东省禽源产超广谱β-内酰胺酶大肠杆菌的分子流行病学分析[J]. 中国畜牧兽医, 2024, 51 (1): 407- 416.
	SONG X B , ZHAO X Y , LI C P , et al. Molecular epidemiological analysis of Avian extended spectrum β-lactamases producing Escherichia coli in Shandong Province[J]. China Animal Husbandry & Veterinary Medicine, 2024, 51 (1): 407- 416.
50	LIU G , ALI T , GAO J , et al. Co-occurrence of plasmid-mediated colistin resistance (mcr-1) and extended-spectrum β-lactamase encoding genes in Escherichia coli from bovine mastitic milk in China[J]. Microb Drug Resist, 2020, 26 (6): 685- 696. doi: 10.1089/mdr.2019.0333
51	ZHAO X L , ZHAO H Y , ZHOU Z L , et al. Characterization of extended-spectrum β-lactamase-producing Escherichia coli isolates that cause diarrhea in sheep in Northwest China[J]. Microbiol Spectr, 2022, 10 (4): e0159522. doi: 10.1128/spectrum.01595-22
52	LIU X Q , LIU H X , LI Y Q , et al. High Prevalence of β-lactamase and plasmid-mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant Escherichia coli from dogs in Shaanxi, China[J]. Front Microbiol, 2016, 7, 1843.
53	杨守深, 王佳慧, 林敏, 等. 宠物源大肠杆菌产ESBLs流行性调查与耐药机制研究[J]. 中国人兽共患病学报, 2019, 35 (12): 1110- 1116.
	YANG S S , WANG J H , LIN M , et al. Prevalence and drug-resistance mechanism of ESBLs in Escherichia coli isolates of pet origins[J]. .Chinese Journal of Zoonoses, 2019, 35 (12): 1110- 1116.
54	CHEN Y Y , LIU Z H , ZHANG Y R , et al. Increasing prevalence of ESBL-producing multidrug resistance Escherichia coli from diseased pets in Beijing, China from 2012 to 2017[J]. Front Microbiol, 2019, 10, 2852. doi: 10.3389/fmicb.2019.02852
55	LIU Y Y , WANG Y , WALSH T R , et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study[J]. Lancet Infect Dis, 2016, 16 (2): 161- 168. doi: 10.1016/S1473-3099(15)00424-7
56	SHEN Z Q , WANG Y , SHEN Y B , et al. Early emergence of mcr-1 in Escherichia coli from food-producing animals[J]. Lancet Infect Dis, 2016, 16 (3): 293. doi: 10.1016/S1473-3099(16)00061-X
57	LIU B T , SONG F J , ZOU M , et al. High incidence of Escherichia coli strains coharboring mcr-1 and bla_NDM from chickens[J]. Antimicrob Agents Chemother, 2017, 61 (3): e02347- 16.
58	CHEN L , ZHANG J L , WANG J W , et al. Newly identified colistin resistance genes, mcr-4 and mcr-5, from upper and lower alimentary tract of pigs and poultry in China[J]. PLoS One, 2018, 13 (3): e0193957. doi: 10.1371/journal.pone.0193957
59	ZHANG J L , CHEN L , WANG J J , et al. Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry[J]. Sci Rep, 2018, 8 (1): 3705. doi: 10.1038/s41598-018-22084-4
60	YI L X , WANG J , GAO Y L , et al. mcr-1-Harboring Salmonella enterica serovar typhimurium sequence type 34 in pigs, China[J]. Emerg Infect Dis, 2017, 23 (2): 291- 295. doi: 10.3201/eid2302.161543
61	CHENG P , YANG Y Q , CAO S , et al. Prevalence and characteristic of swine-origin mcr-1-positive Escherichia coli in Northeastern China[J]. Front Microbiol, 2021, 12, 712707. doi: 10.3389/fmicb.2021.712707
62	TU Z F , GU J , ZHANG H Y , et al. Withdrawal of colistin reduces incidence of mcr-1-harboring IncX4-type plasmids but has limited effects on unrelated antibiotic resistance[J]. Pathogens, 2021, 10 (8): 1019. doi: 10.3390/pathogens10081019
63	SHEN C , ZHONG L L , YANG Y , et al. Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing-based molecular epidemiological study[J]. Lancet Microbe, 2020, 1 (1): e34- e43. doi: 10.1016/S2666-5247(20)30005-7
64	YUAN J Z , WANG X Y , SHI D L , et al. Extensive antimicrobial resistance and plasmid-carrying resistance genes in mcr-1-positive E. coli sampled in swine, in Guangxi, South China[J]. BMC Vet Res, 2021, 17 (2): 86.
65	LI Z G , JIA C Y , HU Z Z , et al. Antimicrobial resistance and genomic characteristics of Escherichia coli strains isolated from the poultry industry in Henan province, China[J]. Microorganisms, 2024, 12 (3): 575. doi: 10.3390/microorganisms12030575
66	MEI C Y , JIANG Y , MA Q C , et al. Low prevalence of mcr-1 in Escherichia coli from food-producing animals and food products in China[J]. BMC Vet Res, 2024, 20 (1): 40. doi: 10.1186/s12917-024-03891-6
67	CHEN X , ZHAO X F , CHE J , et al. Detection and dissemination of the colistin resistance gene, mcr-1, from isolates and faecal samples in China[J]. J Med Microbiol, 2017, 66 (2): 119- 125. doi: 10.1099/jmm.0.000425
68	WANG J , HUANG X Y , XIA Y B , et al. Clonal spread of Escherichia coli ST93 carrying mcr-1-harboring IncN1-IncHI2/ST3 plasmid amongcompanion animals, China[J]. Front Microbiol, 2018, 9, 2989. doi: 10.3389/fmicb.2018.02989
69	YIN Y , QIU L H , WANG G Z , et al. Emergence and transmission of plasmid-mediated mobile colistin resistance gene mcr-10 in humans and companion animals[J]. Microbiol Spectr, 2022, 10 (5): e0209722.. doi: 10.1128/spectrum.02097-22
70	LIU J H , LIU Y Y , SHEN Y B , et al. Plasmid-mediated colistin-resistance genes: mcr[J]. Trends Microbiol, 2024, 32 (4): 365- 378. doi: 10.1016/j.tim.2023.10.006
71	PENG Z , LI X S , HU Z Z , et al. Characteristics of carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-1 and MCR-1 from pig farms in China[J]. Microorganisms, 2019, 7 (11): 482. doi: 10.3390/microorganisms7110482
72	宋倩华. 鸡源产NDM型碳青霉烯酶大肠杆菌的分子特征研究[D]. 广州: 华南农业大学, 2018.
	SONG Q H. Characterization of NDM-producing Escherichia coli in a chicken farm[D]. Guangzhou: South China Agricultural University, 2018. (in Chinese)
73	GUO C H , CHU M J , LIU T , et al. High prevalence and transmission of bla_NDM-positive Escherichia coli between farmed ducks and slaughtered meats: An increasing threat to food safety[J]. Int J Food Microbiol, 2024, 424, 110850. doi: 10.1016/j.ijfoodmicro.2024.110850
74	KONG L H , LEI C W , MA S Z , et al. Various sequence types of Escherichia coli isolates coharboring bla_NDM-5 and mcr-1 genes from a commercial swine farm in China[J]. Antimicrob Agents Chemother, 2017, 61 (3): e02167- 16.
75	吕小月. 中国六市宠物源产碳青霉烯酶大肠杆菌的耐药性初步研究[D]. 广州: 华南农业大学, 2017.
	LV X Y. Emergence of carbapenemase-producing E. coli isolated from companion animals in China[D]. Guangzhou: South China Agricultural University, 2017. (in Chinese)
76	MITTAL R P , RANA A , JAITAK V . Essential oils: An impending substitute of synthetic antimicrobial agents to overcome antimicrobial resistance[J]. Curr Drug Targets, 2019, 20 (6): 605- 624. doi: 10.2174/1389450119666181031122917
77	牛艺儒, 刘雁军, 宋燕. 鱼腥草对仔猪副伤寒沙门氏菌耐药质粒消除作用的研究[J]. 饲料广角, 2010 (15): 37-38, 50. doi: 10.3969/j.issn.1002-8358.2010.15.012
	NIU Y R , LIU Y J , SONG Y . Effect of Houttuynia tuyniae on the elimination of drug-resistant plasmid of Salmonella paratyphi in piglets[J]. Feed China, 2010 (15): 37-38, 50. doi: 10.3969/j.issn.1002-8358.2010.15.012
78	刘超怡, 徐海瑛, 李小妞, 等. 艾叶提取物对禽源大肠杆菌耐药性消除作用的研究[J]. 畜牧与兽医, 2020, 52 (6): 137- 141.
	LIU C Y , XU H Y , LI X N , et al. Elimination effect of Artemisia argyi extract on drug resistance of avian Escherichia coli[J]. Animal Husbandry & Veterinary Medicine, 2020, 52 (6): 137- 141.
79	王永芬, 席磊, 边传周, 等. 猪致病性大肠杆菌耐药质粒检测及其中药消除作用研究[J]. 中国预防兽医学报, 2011, 33 (12): 932- 935. doi: 10.3969/j.issn.1008-0589.2011.12.05
	WANG Y F , XI L , BIAN C Z , et al. Drug resistance plasmid detection in pathogenic swine Escherichia coli and elimination with traditional Chinese herbs[J]. Chinese Journal of Preventive Veterinary Medicine, 2011, 33 (12): 932- 935. doi: 10.3969/j.issn.1008-0589.2011.12.05
80	李栋. 禽源大肠杆菌质粒介导氟喹诺酮类耐药基因的检测及中药消除耐药性研究[D]. 扬州: 扬州大学, 2015.
	LI D. Study on the detection of plasmid-mediated fluoroquinolone resistance genes in avian Escherichia coli isolates and the drug-resistance eliminating effect of traditional Chinese medicine[D]. Yangzhou: Yangzhou University, 2015. (in Chinese)
81	张石磊, 翟向和, 王春光, 等. 小檗碱对禽源大肠杆菌抑菌作用及耐药消除作用的转录组学分析[J]. 中国畜牧兽医, 2017, 44 (5): 1518- 1525.
	ZHANG S L , ZHAI X H , WANG C G , et al. Study on antimicrobial effect of berberine sulfate on Avian Escherichia coli and elimination of levofloxacin resistance based on transcriptome sequencing[J]. China Animal Husbandry & Veterinary Medicine, 2017, 44 (5): 1518- 1525.
82	左丽, 旷年玲, 王芝超, 等. 小檗碱消除ESBLs大肠杆菌耐药性的研究[J]. 黑龙江畜牧兽医, 2024 (1): 54- 58.
	ZUO L , KUANG N L , WANG Z C , et al. A study on the elimination of drug resistance of ESBLs E.coli by berberine[J]. Heilongjiang Animal Science and Veterinary Medicine, 2024 (1): 54- 58.
83	姚姗姗, 张石磊, 梁存军, 等. 基于转录组学技术分析绿原酸对鸡源大肠杆菌抑菌及耐药消除的作用机制[J]. 中国畜牧兽医, 2020, 47 (12): 4156- 4165.
	YAO S S , ZHANG S L , LIANG C J , et al. Analysis of bacteriostatic and drug resistance elimination mechanisms of chicken-derived Escherichia coli by chlorogenic acid based on transcriptome technology[J]. China Animal Husbandry & Veterinary Medicine, 2020, 47 (12): 4156- 4165.
84	宁官保, 牛艺儒, 张鼎, 等. 鸡源大肠杆菌耐药性分析及中药对大肠杆菌耐药性消除作用的研究[J]. 畜牧兽医学报, 2015, 46 (6): 1018- 1025.
	NING G B , NIU Y R , ZHANG D , et al. Drug resistance analysis of Escherichia coli isolated from chicken and study on elimination of drug resistance by traditional Chinese medicine[J]. Acta Veterinaria et Zootechnica Sinica, 2015, 46 (6): 1018- 1025.
85	李志君, 鲁孟佳, 张雯, 等. 中药复方对猪源多重耐药大肠埃希氏菌的耐药性消除研究[J]. 动物医学进展, 2022, 43 (2): 76- 80. doi: 10.3969/j.issn.1007-5038.2022.02.014
	LI Z J , LU M J , ZHANG W , et al. Drug resistance elimination effect of traditional Chinese medicine compounds on multi-drug resistant Escherichia coli derived from swine[J]. Progress in Veterinary Medicine, 2022, 43 (2): 76- 80. doi: 10.3969/j.issn.1007-5038.2022.02.014
86	肖潇, 李英伦, 杨锐. 复方蒲公英对金黄色葡萄球菌耐药质粒的体外消除试验[J]. 中国兽医科学, 2010, 40 (3): 307- 311.
	XIAO X , LI Y L , YANG R . Elimination test in vitro of complex prescription dandelion's injection on antibiotic-resistant plasmid of Staphylococcus aureus[J]. Chinese Veterinary Science, 2010, 40 (3): 307- 311.
87	王婷婷, 邓旭明, 邱家章. MCR-1抑制剂与粘菌素联合治疗MCR-1阳性克雷伯菌肺炎的作用[C]//中国畜牧兽医学会兽医药理毒理学分会. 中国畜牧兽医学会兽医药理毒理学分会第十五次学术讨论会论文集. 吉林大学动物医学学院, 2019: 86.
	WANG T T, DENG J M, QIU J Z. Effect of MCR-1 inhibitor and colistin in the treatment of MCR-1 positive Klebsiella pneumonia [C]//Chinese Society of Animal Husbandry and Veterinary Medicine Veterinary Toxicology Branch. Proceedings of the 15th Symposium of Veterinary Pharmacology and Toxicology Branch of Chinese Society of Animal Husbandry and Veterinary Medicine. College of Veterinary Medicine, Jilin University, 2019: 86. (in Chinese)
88	贾泽, 王春光, 张石磊, 等. 赤芍水提物及芍药苷对大肠杆菌抗菌增敏活性的影响[J]. 中国兽医学报, 2019, 39 (10): 2026- 2032.
	JIA Z , WANG C G , ZHANG S L , et al. Antibacterial and sensitizing activity of Paeonia lactiflora aqueous extract and paeoniflorin to Escherichia coli[J]. Chinese Journal of Veterinary Science, 2019, 39 (10): 2026- 2032.
89	刘超怡, 王宇泊, 赵一霖, 等. 黄藤素与6种抗生素联用对禽源耐药金黄色葡萄球菌的体外抗菌作用[J]. 中国兽医杂志, 2021, 57 (10): 34- 37. doi: 10.3969/j.issn.0529-6005.2021.10.zgsyzz202110008
	LIU C Y , WANG Y B , ZHAO Y L , et al. In vitro antibacterial effect of Fibriuretinin combined with six antibiotics against multidrug resistant Staphylococcus aureus[J]. Chinese Journal of Veterinary Medicine, 2021, 57 (10): 34- 37. doi: 10.3969/j.issn.0529-6005.2021.10.zgsyzz202110008
90	卢娜, 邓旭明, 邱家章. 丹皮酚恢复多粘菌素B对产MCR-1细菌的抗菌活性[C]//中国畜牧兽医学会兽医药理毒理学分会. 中国畜牧兽医学会兽医药理毒理学分会第十五次学术讨论会论文集. 吉林大学动物医学学院, 2019: 91-92.
	LU N, DENG X M, QIU J Z. Paeonol restores the antibacterial activity of polymyxin B against MCR-1 producing bacteria [C]//Chinese Society of Animal Husbandry and Veterinary Medicine Branch of Veterinary Pharmacology and Toxicology. Proceedings of the 15th Symposium of Veterinary Pharmacology and Toxicology Branch of Chinese Society of Animal Husbandry and Veterinary Medicine. College of Veterinary Medicine, Jilin University, 2019: 91-92. (in Chinese)
91	WANG M Z , MA B , NI Y F , et al. Restoration of the antibiotic susceptibility of methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamases Escherichia coli through combination with chelerythrine[J]. Microb Drug Resist, 2021, 27 (3): 337- 341. doi: 10.1089/mdr.2020.0044
92	BUSH K , BRADFORD P A . Interplay between β-lactamases and new β-lactamase inhibitors[J]. Nat Rev Microbiol, 2019, 17 (5): 295- 306. doi: 10.1038/s41579-019-0159-8
93	SHRIVASTAV A , SHARMA R K , SHRIVASTAVA N , et al. Study of inhibitory potential and percent inhibition of oil of Syzygium aromaticum and leaves of Ocimum sanctum on ESBL enzyme from Escherichia coli in broilers of Jabalpur[J]. Indian J Pharmacol, 2019, 51 (5): 337- 342. doi: 10.4103/ijp.IJP_87_17
94	曹敏. 天然β-内酰胺酶抑制剂的筛选研究[D]. 贵阳: 贵州大学, 2016.
	CAO M. Screening study of natural β-lactamase inhibitors [D]. Guiyang: Guizhou University, 2016. (in Chinese)
95	WANG Y L , SUN X D , KONG F R , et al. Specific NDM-1 inhibitor of isoliquiritin enhances the activity of meropenem against NDM-1-positive Enterobacteriaceae in vitro[J]. Int J Environ Res Public Health, 2020, 17 (6): 2162. doi: 10.3390/ijerph17062162
96	DHARA L , TRIPATHI A . Cinnamaldehyde: a compound with antimicrobial and synergistic activity against ESBL-producing quinolone-resistant pathogenic Enterobacteriaceae[J]. Eur J Clin Microbiol Infect Dis, 2020, 39 (1): 65- 73. doi: 10.1007/s10096-019-03692-y
97	PAL A , TRIPATHI A . Demonstration of bactericidal and synergistic activity of quercetin with meropenem among pathogenic carbapenem resistant Escherichia coli and Klebsiella pneumoniae[J]. Microb Pathog, 2020, 143, 104120. doi: 10.1016/j.micpath.2020.104120
98	SUN T , LI X D , HONG J , et al. Inhibitory effect of two traditional Chinese medicine monomers, berberine and matrine, on the quorum sensing system of antimicrobial-resistant Escherichia coli[J]. Front Microbiol, 2019, 10, 2584. doi: 10.3389/fmicb.2019.02584
99	JIN L M , SHEN H , CHE X Y , et al. Anti-bacterial mechanism of baicalin-tobramycin combination on carbapenem-resistant Pseudomonas aeruginosa[J]. World J Clin Cases, 2023, 11 (17): 4026- 4034. doi: 10.12998/wjcc.v11.i17.4026
100	PENG L Y , YUAN M , WU Z M , et al. Anti-bacterial activity of baicalin against APEC through inhibition of quorum sensing and inflammatory responses[J]. Sci Rep, 2019, 9 (1): 4063. doi: 10.1038/s41598-019-40684-6
101	ZHANG N , LIU W G , QIAN K J . In-vitro antibacterial effect of tea polyphenols combined with common antibiotics on multidrug-resistant Klebsiella pneumoniae[J]. Minerva Med, 2020, 111 (6): 536- 543.
102	孙仲琳, 崔锦, 王锐, 等. 细菌耐药的外排机制及其抑制剂[J]. 复旦学报(自然科学版), 2019, 58 (2): 135- 143.
	SUN Z L , CUI J , WANG Y , et al. The efflux mechanism of bacterial drug resistance and inhibitors[J]. Journal of Fudan University (Natural Science), 2019, 58 (2): 135- 143.
103	YAMASAKI S , NIKAIDO E , NAKASHIMA R , et al. The crystal structure of multidrug-resistance regulator RamR with multiple drugs[J]. Nat Commun, 2013, 4, 2078. doi: 10.1038/ncomms3078
104	LI X B , SONG Y Q , WANG L N , et al. A potential combination therapy of berberine hydrochloride with antibiotics against multidrug-resistant Acinetobacter baumannii[J]. Front Cell Infect Microbiol, 2021, 11, 660431. doi: 10.3389/fcimb.2021.660431
105	SURIYANARAYANAN B , SAROJINI SANTHOSH R . Docking analysis insights quercetin can be a non-antibiotic adjuvant by inhibiting Mmr drug efflux pump in Mycobacterium sp. and its homologue EmrE in Escherichia coli[J]. J Biomol Struct Dyn, 2015, 33 (8): 1819- 1834. doi: 10.1080/07391102.2014.974211
106	李悦怡, 李贤煜, 杨伟峰, 等. 痰热清注射液与抗生素对多重耐药铜绿假单胞菌外排泵的作用[J]. 中国实验方剂学杂志, 2020, 26 (14): 92- 98.
	LI Y Y , LI X Y , YANG W F , et al. Effect of tanreging injection and antibiotics on multi-drug resistant Pseudomonas aeruginosa efflux pump[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2020, 26 (14): 92- 98.
107	张鹏, 王春光, 张子闯, 等. 甘草酸对多重耐药大肠杆菌的抗菌增敏作用[J]. 畜牧兽医学报, 2021, 52 (5): 1386- 1395.
	ZHANG P , WANG C G , ZHANG Z C , et al. Antibacterial and sensitizing effects of glycyrrhizic acid on multidrug resistant Escherichia coli[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52 (5): 1386- 1395.
108	朱利霞, 王洪彬, 史秋梅, 等. 中草药对细菌耐药质粒的消除作用研究[J]. 中国兽药杂志, 2018, 52 (11): 72- 79.
	ZHU L X , WANG H B , SHI Q M , et al. Study on elimination of bacterial drug resistant plasmids by Chinese herbs[J]. Chinese Journal of Veterinary Drug, 2018, 52 (11): 72- 79.
109	刘洋. 消除鸡源大肠杆菌β-内酰胺类药物耐药中药筛选[D]. 邯郸: 河北工程大学, 2020.
	LIU Y. Traditional Chinese herbs screening for eliminating drugs resistance of beta-lactam type of Escherichia coli from chickens[D]. Handan: Hebei University of Engineering, 2020. (in Chinese)
110	郑乐怡. 大叶桉挥发油对耐甲氧西林金黄色葡萄球菌体外抑制及质粒消除作用[J]. 广东医学院学报, 2016, 34 (2): 149- 151. doi: 10.3969/j.issn.1005-4057.2016.02.011
	ZHENG L Y . In vitro inhibition and plasmid elimination of Eucalyptus robusta-derived volatile oil in methicillin resistant Staphylococcus aureus[J]. Journal of Guangdong Medical University, 2016, 34 (2): 149- 151. doi: 10.3969/j.issn.1005-4057.2016.02.011
111	TRABELSI A , EL KAIBI M A , ABBASSI A , et al. Phytochemical study and antibacterial and antibiotic modulation activity of Punica granatum (Pomegranate) leaves[J]. Scientifica (Cairo), 2020, 2020, 8271203.

年份 Year	区域 Region	来源 Provenance	类别 Category								多重耐药率 Multidrug resistance rate	参考文献 References
年份 Year	区域 Region	来源 Provenance	β-内酰胺类 β-Lactams	喹诺酮类 Quinolones	氨基糖苷类 Aminoglycosides	大环内酯类 Macrolides	四环素类 Tetracyclines	酰胺醇类 Amphenicols	多肽类 Polypeptides	磺胺类 Sulfonamides	多重耐药率 Multidrug resistance rate	参考文献 References
2012	辽宁	禽	27.2~91.1	34.4~37.8	19.5~75.2	—	72.5	42.1~48	13.6	76.2	18.87	[7]
2013	西藏	牛	100	90.9~100	90.9	—	81.8	—	—	—	100	[8]
2014	广东	猪、鸡	30.5	11	6.8	—	78.8	17.8	—	48.3	52.5	[9]
2016	河北、河南、四川	猪	94.4	59.3	68.5	61.1	100	61.1	100	85.2	97	[10]
2015—2017	山东、安徽、山西	鸡	87.1	77.1	60.7	—	89.3	69.1	17	—	—	[11]
2018—2019	宁夏	牛	＞90	75.8	＞70	69.35	100	98.39	—	95.16	—	[12]
2018—2019	河南、湖北等31省	猪	43.56	81.56	—	—	96.26	82.04	3.79	80.38	90.54	[13]
2019	安徽、河北、山西、陕西	猪	16.7	46.6	68.2	48.5	73.5	56.1	—	71.6	78.7	[14]
2020	浙江	猪、鸡	78.27	27.79	68.92	—	92.92	83.11	1.36	93.05	88.68	[15]
2020	四川	鹿	24.2	15.92	6.37	—	24.89	10.19	—	85.99	24.2	[26]
2021—2022	四川、重庆、安徽	鸭	72.1	59.2	62.7	15.9	88.1	72.1	2.5	88.1	88.1	[16]
2021—2022	四川	犬	76.3	25.93	33.33	—	64.44	30.37	—	59.26	54.81	[27]

[1]	WU Junjie, Lü Shiming, LONG Xiaoxia, WANG Zhong, WANG Liqi. Research Progress on the Antibacterial Effects and Mechanisms of Traditional Chinese Medicine and Active Ingredients against Drug-resistant Bacteria [J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(4): 1632-1647.
[2]	QIU Qian, SANG Rui, WANG Wei, LIU Xinman, YU Minghong, LIU Xiaotong, YU Tian, ZHANG Xuemei. Study on the Activity of Huning Powder against Chicken Lung-derived E. coli and the in vitro Effects of Anti-inflammation and Anti-oxidation [J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(4): 1969-1980.
[3]	LI Pengxu, LI Shijing, SUN Jun, XIANG Wei, ZHAO Miaomiao, HOU Tianmu, LI Huaming, GUANG Min, CHEN Ruige, XU Mengran, WU Xiaomin, JIANG Hexiang, LEI Liancheng, ZHANG Fuxian. Molecular Subtyping and Identification of Streptococcus suis Meningitidis Type 2 and Its Biological Characteristics [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 1192-1207.
[4]	PAN Binglin, WANG Sinan, YAO Guozhong, ZHAI Ruidong, SONG Houhui, CHENG Changyong, LEI Lei. Disinfectant Susceptibility Analysis of tet(X4)-Containing Porcine Escherichia coli [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(12): 5880-5885.
[5]	GUO Dawei, HOU Silu, CHI Yujia, YU Feike, YU Xiaohan, DENG Qian, XIAO Chuanming, LIU Xiaoye, DONG Hong. Clinical Research of Qiying Decoction and Zigan Decoction on Promoting Reproductive Performance of Sows and Growth Performance of Weaned Piglets [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1994-2004.
[6]	YU Yun, XIANG Yong, LI Qingbo, LIU Peng, LI Lizhen, LIAO Ming, CAO Weisheng. Isolation, Identification and Drug Resistance Analysis of Pseudomonas aeruginosa from Dead Embryos and Environment Samples of Hatchery in Breeding Chicken Farms [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(2): 548-555.
[7]	LI Huaming, XIANG Wei, LU Wenbing, LIU Feng, LEI Liancheng, ZHANG Fuxian. Pathogenicity and Drug Sensitivity Analysis of a Porcine Klebsiella pneumoniae Type ST-35 [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(12): 4356-4366.
[8]	ZHANG Haixia, ZHANG Zhenbiao, DAI Hegen, SONG Yu, LI Lei, XIA Zhaofei. Analysis of Epidemiological Characteristics of Clinical Staphylococcus pseudintermedius Isolated from Dogs [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(9): 2561-2568.
[9]	ZHANG Jing, CAI Ping, HE Yizhuo, CHEN Weitao, HUANG Yuchen, JIANG Hongxia. Prevalence of Antimicrobial Resistance and Virulence Factors in Enterococci from Poultry Farms in Guangdong Province [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(9): 2650-2659.
[10]	WANG Zilin, TANG Ziheng, LIN Zening, LIU Wenzi, LIU Rong, ZHANG Jiahui, SHEN Xiangguang. Effect of Traditional Chinese Medicine Compound Synephrine on the Detection of β-agonists Using Colloidal Gold Immunochromatographic Assay [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(12): 3675-3680.
[11]	ZHANG Hang, YANG Feng, LI Xinpu, WANG Xurong, LUO Jinyin, LI Hongsheng. Study on Relationship between Antimicrobial Resistance and Efflux Pump Related Genes of Methicillin-Resistant Staphylococcus aureus in Dairy Cow [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(11): 2326-2332.
[12]	ZHANG Juan, WANG Jun-wu, HAN Ye-chen, YUN Shi-yu, WU Hai-ping, ZHAO Dong-dong, WEN Shuang, WANG Zhuo, CHENG Jia, SU Xiao-fei, ZHU Yu-bo, SUN Yao-gui, WANG Wen-kui, LI Hong-quan, DUAN Zhi-bian. The Effect of the Compound Traditional Chinese Medicine on Endothelium Derived Multiplication Factor in Lung of Broilers with Ascites Syndrome [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(1): 174-184.
[13]	HAN Ye-chen, ZHANG Juan, WANG Jun-wu, YUN Shi-yu, WU Hai-ping, WEN Shuang, ZHAO Dong-dong, WANG Zhuo, SU Xiao-fei, ZHU Yu-bo, CHENG Jia, SUN Yao-gui, WANG Wen-kui, LI Hong-quan, DUAN Zhi-bian. The Effect of the Compound Recipe of the Traditional Chinese Medicine on Collagen in Liver of Broilers with Ascites Syndrome [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(11): 2310-2317.
[14]	ZHANG Jin-bao，MA Chun-fang，YU Ting，LI Xiao-na，WEI Xiao-ping，WANG Gui-qin. Detection of Virulence Genes and Antimicrobial Resistance Analysis of Escherichia coli Isolated from Dairy Cow Mastitis in Ningxia [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(1): 177-182.
[15]	WANG Xiao，YU Ying. Infectious Status of Mastitis in Dairy Cattle Induced by Staphylococcus aureus and Its Advances on Epidemiological Patterns and Antimicrobial Resistance in Northern China [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(9): 1477-1488.

Research Progress on Antimicrobial Resistance of Animal-derived Bacteria and Elimination of Antimicrobial Resistance by Traditional Chinese Medicine

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 3

References 111

Related Articles 15

Recommended Articles

Metrics

Comments