甲型疱疹病毒亚科的疱疹病毒囊膜糖蛋白gC对病毒感染复制的影响

doi:10.11843/j.issn.0366-6964.2022.09.005

Abstract

Abstract: Alpha herpesvirus has a wide range of hosts, and can infect mammals, amphibians and poultry. It mainly invades the skin, mucous membrane and nerve tissue of the host and latently infects the nerve tissue of the host. Once infected, it is difficult to be eradicated. gC is one of the envelope glycoproteins of alpha herpesvirus, which plays an important role in the process of viral infection and replication. gC binds to receptors on the cell to help the virus adsorb to the surface of the host, mediates the invasion of the virus into epithelial cells at low pH, and affects the replication of the viral genome. In addition, gC helps the virus evade the neutralization of complement and antibodies, and promotes the absorption and invasion of the virus. In this review, the related functions of gC affecting viral infection and replication were reviewed to provide reference for the study of gC and the life cycle of the alpha herpesvirus, as well as the research of gC subunit vaccine and mRNA vaccine.

Key words: alpha herpesvirus, gC, adsorption, horizontal transmission, immune evasion

CLC Number:

S852.659.1

FENG Xin, WANG Mingshu, CHENG Anchun. The Role of Alpha Herpesvirus Envelope Glycoprotein C on Virus Infection and Replication[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(9): 2867-2876.

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The Role of Alpha Herpesvirus Envelope Glycoprotein C on Virus Infection and Replication

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