Acta Veterinaria et Zootechnica Sinica ›› 2021, Vol. 52 ›› Issue (8): 2317-2325.doi: 10.11843/j.issn.0366-6964.2021.08.025
• CLINICAL VETERINARY MEDICINE • Previous Articles Next Articles
HE Shangwen1, WANG Yueming1, ZHANG Hui1, HOU Silu1, LIU Xiaoye2*, DONG Hong1*
Received:
2020-12-09
Online:
2021-08-23
Published:
2021-08-21
CLC Number:
HE Shangwen, WANG Yueming, ZHANG Hui, HOU Silu, LIU Xiaoye, DONG Hong. Pulsatilla Decoction Alleviates LPS-induced Inflammation of Microvascular Endothelial Cells by Inhibiting the TLR4-ERK1/2 Signaling Pathway[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(8): 2317-2325.
[1] | 金燊懿, 毕凌, 焦丽静, 等. 白头翁汤化学成分及药理作用研究进展[J]. 上海中医药杂志, 2019, 53(3):109-111.JIN S Y, BI L, JIAO L J, et al. Research progress in chemical constituents and pharmacological effects of Pulsatilla decoction[J]. Shanghai Journal of Traditional Chinese Medicine, 2019, 53(3):109-111.(in Chinese) |
[2] | 邹志强, 刘晏灼, 于如娟, 等. 白头翁汤药理作用研究进展[J]. 山东畜牧兽医, 2020, 41(1):63-65.ZOU Z Q, LIU Y Z, YU R J, et al. Research progress on pharmacological action of Pulsatilla decoction[J]. Shandong Journal of Animal Science and Veterinary Medicine, 2020, 41(1):63-65.(in Chinese) |
[3] | 王丽, 陶兴宝, 欧阳净, 等. 白头翁汤对痢疾杆菌的体外抑菌作用研究[J]. 中医药信息, 2020, 37(5):49-53.WANG L, TAO X B, OUYANG J, et al. Bacteriostasis in vitro effect of baitouweng decoction on shigella dysenteriae[J]. Information on Traditional Chinese Medicine, 2020, 37(5):49-53.(in Chinese) |
[4] | LIU X Y, HE S W, LI Q Y, et al. Comparison of the gut microbiota between Pulsatilla decoction and levofloxacin hydrochloride therapy on Escherichia coli infection[J]. Front Cell Infect Microbiol, 2020, 10:319. |
[5] | 张晓音, 吴旻, 李雨萌, 等. 脂多糖的效应及其机理研究进展[J]. 动物医学进展, 2015, 36(12):133-136.ZHANG X Y, WU M, LI Y M, et al. Progress on Effects and mechanisms of lipopolysaccharides[J]. Progress in Veterinary Medicine, 2015, 36(12):133-136.(in Chinese) |
[6] | YUAN H X, FENG X E, LIU E L, et al. 5, 2'-dibromo-2, 4', 5'-trihydroxydiphenylmethanone attenuates LPS-induced inflammation and ROS production in EA. hy926 cells via HMBOX1 induction[J]. J Cell Mol Med, 2019, 23(1):453-463. |
[7] | ZHONG M, ZHANG X, SHI X M, et al. Halofuginone inhibits LPS-induced attachment of monocytes to HUVECs[J]. Int Immunopharmacol, 2020, 87:106753. |
[8] | SIVAK K V, STOSMAN K I, RASSOKHA T A, et al. The effect of TLR4 blockade on some indicators of systemic inflammatory response to Proteus mirabilis LPS in rats[J]. Bull Exp Biol Med, 2020, 169(6):795-797. |
[9] | PARK B S, LEE J O. Recognition of lipopolysaccharide pattern by TLR4 complexes[J]. Exp Mol Med, 2013, 45(12):e66. |
[10] | 胡屹屹, 穆祥, 胡元亮. 白头翁汤及其主要成分对LPS诱导内皮细胞分泌NO、E-selectin和IL-8的影响[J]. 畜牧兽医学报, 2012, 43(1):145-151.HU Y Y, MU X, HU Y L. Effects of pulsatillae decoction and its main ingredients on LPS-induced NO, E-selectin and IL-8 secretion of endothelial cells[J]. Acta Veterinaria et Zootechnica Sinica, 2012, 43(1):145-151.(in Chinese) |
[11] | 胡屹屹, 穆祥, 胡元亮. 白头翁汤对内毒素诱导血管内皮细胞基因表达谱的影响[J]. 畜牧兽医学报, 2013, 44(10):1675-1684.HU Y Y, MU X, HU Y L. Effects of pulsatillae decoction on gene expression of LPS-induced endothelial cell[J]. Acta Veterinaria et Zootechnica Sinica, 2013, 44(10):1675-1684.(in Chinese) |
[12] | 刘晓晔, 张涛, 董虹, 等. 白头翁汤对大鼠跨内皮迁移的中性粒细胞溶菌酶的影响[J]. 畜牧兽医学报, 2014, 45(1):142-146.LIU X Y, ZHANG T, DONG H, et al. Effects of Pulsatilla decoction on the lysozyme of transendothelial migration of polymorph nuclear neutrophils in rat[J]. Acta Veterinaria et Zootechnica Sinica, 2014, 45(1):142-146.(in Chinese) |
[13] | 王明明, 杨舒, 董虹, 等. 白头翁汤通过保护微血管内皮细胞的完整性及PMNs迁移杀菌功能的影响[J]. 畜牧兽医学报, 2016, 47(4):836-843.WANG M M, YANG S, DONG H, et al. Pulsatillae decoction improves the bactericidal capacity of neutrophils by protection of integrity of microvascular endothelial cells[J]. Acta Veterinaria et Zootechnica Sinica, 2016, 47(4):836-843.(in Chinese) |
[14] | 中国兽药典委员会. 中华人民共和国兽药典-二部[M]. 北京:化学工业出版社, 2010:590-591.Committee of Chinese Veterinary Pharmacopoeia. Veterinary pharmacopoeia of the people's republic of China (Volume Ⅱ)[M]. Beijing:Chemical Industry Press, 2010:590-591.(in Chinese) |
[15] | 武果桃, 牛国庆. MVECs抗炎症感染作用及应用前景[J]. 养猪, 2019(2):94-96.WU G T, NIU G Q. The regulation role in anti inflammation of microvascular endothelial cells[J]. Swine Production, 2019(2):94-96.(in Chinese) |
[16] | LEGROS N, POHLENTZ G, STEIL D, et al. Shiga toxin-glycosphingolipid interaction:status quo of research with focus on primary human brain and kidney endothelial cells[J]. Int J Med Microbiol, 2018, 308(8):1073-1084. |
[17] | HUANG J, KELLY C P, BAKIRTZI K, et al. Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis[J]. Nat Microbiol, 2019, 4(2):269-279. |
[18] | KONRAD F M, WITTE E, VOLLMER I, et al. Adenosine receptor A2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium[J]. Am J Physiol Lung Cell MolPhysiol, 2012, 303(5):L425-L438. |
[19] | 陈燕燕, 欧希龙. 中性粒细胞影响炎症反应的受控因素及与机体损伤关系[J]. 东南大学学报:医学版, 2013, 32(4):511-514.CHEN Y Y, OU X L. The controlled factors of neutrophils affecting inflammatory response and their relationship with body injury[J]. Journal of Southeast University:Medical Science Edition, 2013, 32(4):511-514.(in Chinese) |
[20] | MALDONADO R F, SÁ-CORREIA I, VALVANO M A. Lipopolysaccharide modification in Gram-negative bacteria during chronic infection[J]. FEMS Microbiol Rev, 2016, 40(4):480-493. |
[21] | 尤青海, 王巾枚, 孙耕耘, 等. PI3K/Akt信号通路参与LPS诱导大鼠肺微血管内皮细胞表达RACK1及rac1[J]. 安徽医科大学学报, 2020, 55(1):41-45.YOU Q H, WANG J M, SUN G Y, et al. The PI3K/Akt signaling pathway involved in the expression of RACK1 and rac1 in the rat pulmonary microvascular endothelial cells induced by lipopolysaccharide[J]. Acta Universitatis Medicinalis Anhui, 2020, 55(1):41-45.(in Chinese) |
[22] | 刘焕龙, 陈天鹏, 苏素文, 等. Apelin-13对脂多糖诱导大鼠肺微血管内皮细胞炎性因子表达的影响及机制研究[J]. 中国临床药理学杂志, 2020, 36(2):142-145.LIU H L, CHEN T P, SU S W, et al. Effects of Apelin-13 on the level of inflammatory factors induced by LPS in rat PMVECs and the mechanisms[J]. The Chinese Journal of Clinical Pharmacology, 2020, 36(2):142-145.(in Chinese) |
[23] | 秦劭晨, 王爱梅, 张晋岳, 等. 槲皮素对脂多糖诱导人脑微血管内皮细胞的作用机制[J]. 湖南师范大学自然科学学报, 2019, 42(6):38-45.QIN S C, WANG A M, ZHANG J Y, et al. Effect of quercetinon human brain microvascular endothelial cells induced by lipopolysaccharide[J]. Journal of Natural Science of Hunan Normal University, 2019, 42(6):38-45.(in Chinese) |
[24] | 康春燕, 李婷, 邹琳. 等. 红景天苷抑制模拟微重力诱导的肺微血管内皮细胞凋亡[J]. 南方医科大学学报, 2011, 31(4):649-652.KANG C Y, LI T, ZOU L, et al. Salidroside inhibits clinorotation-induced apoptosis in pulmonary microvascular endothelial cells[J]. Journal of Southern Medical University, 2011, 31(4):649-652. (in Chinese) |
[25] | HU G, WANG J J, HONG D, et al. Effects of aqueous extracts of Taraxacum Officinale on expression of tumor necrosis factor-alpha and intracellular adhesion molecule 1 in LPS-stimulated RMMVECs[J]. BMC Complement Altern Med, 2017, 17(1):38. |
[26] | 节阳华, 杨晓蓓, 陈卫东. 白头翁汤对结直肠癌小鼠炎性微环境的影响[J]. 广州中医药大学学报, 2020, 37(12):2406-2412.JIE Y H, YANG X B, CHEN W D. Effects of baitouweng decoction on inflammatory microenvironment in mice with colorectal cancer[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2020, 37(12):2406-2412. (in Chinese) |
[27] | 李盼盼, 李东阳, 李毅. 白头翁汤治疗溃疡性结肠炎作用机制研究进展[J]. 现代中医药, 2019, 39(6):130-133.LI P P, LI D Y, LI Y. Research progress of baitouweng decoction on the treatment of ulcerative colitis[J]. Modern Traditional Chinese Medicine, 2019, 39(6):130-133.(in Chinese) |
[28] | CIESIELSKA A, MATYJEK M, KWIATKOWSKA K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling[J]. Cell Mol Life Sci, 2021, 78(4):1233-1261. |
[29] | 严宁, 杨春霞, 马娟, 等. β-谷甾醇对大鼠心肌缺血再灌注损伤和ERK1/2信号通路的影响[J]. 心血管病学进展, 2020, 41(3):321-325.YAN N, YANG C X, MA J, et al. Effects of β-sitosterolon myocardial ischemia-reperfusion injury and ERK1/2 signaling pathway in rats[J]. Advances in Cardiovascular Diseases, 2020, 41(3):321-325.(in Chinese) |
[30] | 田华, 黄毓娟. 蒲公英多糖对幽门螺杆菌相关性胃炎大鼠胃黏膜炎性反应及MAPK/ERK通路的影响[J]. 现代中西医结合杂志, 2019, 28(35):3877-3880.TIAN H, HUANG Y J. Effect of dandelion polysaccharide on gastric mucosal inflammatory response and MAPK/ERK pathway in rats with Helicobacter pylori-associated gastritis[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2019, 28(35):3877-3880.(in Chinese) |
[31] | 廖媛, 池晓玲, 杨以琳, 等. 脂必泰对非酒精性脂肪肝病大鼠肝组织ERK和TLR4表达的影响[J]. 中药药理与临床, 2019, 35(6):130-134.LIAO Y, CHI X L, YANG Y L, et al. Effects of zhibitai on the expressions of ERK and TLRs in liver tissues of NAFLD rats[J]. Pharmacology and Clinics of Chinese Materia Medica, 2019, 35(6):130-134.(in Chinese) |
[32] | LI Y P, YANG Q. Effect of PD98059 on chemotherapy in patients with colorectal cancer through ERK1/2 pathway[J]. J Buon, 2019, 24(5):1837-1844. |
[33] | HOU L, HOU X F, WANG L J, et al. PD98059 impairs the cisplatin-resistance of ovarian cancer cells by suppressing ERK pathway and epithelial mesenchymal transition process[J]. Cancer Biomark, 2017, 21(1):187-194. |
[34] | 杨扬, 夏冬琴, 王维. 抑制剂PD98059阻断MAPK/ERK信号通路对结直肠癌细胞增殖抑制和凋亡促进作用的研究[J]. 结直肠肛门外科, 2019, 25(6):657-661, 667.YANG Y, XIA D Q, WANG W. Effects of inhibitor PD98059 blocking MAPK/ERK pathway on inhibiting proliferation and promoting apoptosis of colorectal cancer cells[J]. Journal of Colorectal & Anal Surgery, 2019, 25(6):657-661, 667.(in Chinese) |
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