中药组方优化试验设计方法概述

doi:10.11843/j.issn.0366-6964.2021.03.001

Abstract

Abstract: The study of optimization of prescription is an important link in the research of Chinese medicine prescription and a key step in the industrialization and promotion of Chinese medicine. This article introduces the concept of formulating traditional Chinese medicine, the principle, purpose, significance and guiding ideology of formulating formulas, and summarizes the methods used in formulating formulas in recent years are mainly divided into two categories, compared the experimental designs based on modern mathematical models (orthogonal design, homogeneous design, baseline proportional design, Plackett-Burman design, central composite design, Box-Behnken, Doehlert design), and analyzed the advantages and disadvantages in experimental arrangements, data analysis and fitting models, the scope of application and practicability in the field of formulation optimization, and put forward the prospect of future method design.

Key words: Chinese medicine, prescription optimization, experimental design, mathematical model

CLC Number:

S853.1

WANG Yushan, LIN Degui, LIN Jiahao. Summary of Experimental Design Methods for Optimization of Complex Prescription of Chinese Medicine[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(3): 565-575.

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Summary of Experimental Design Methods for Optimization of Complex Prescription of Chinese Medicine

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[1]	LI Pengxu, LI Shijing, SUN Jun, XIANG Wei, ZHAO Miaomiao, HOU Tianmu, LI Huaming, GUANG Min, CHEN Ruige, XU Mengran, WU Xiaomin, JIANG Hexiang, LEI Liancheng, ZHANG Fuxian. Molecular Subtyping and Identification of Streptococcus suis Meningitidis Type 2 and Its Biological Characteristics [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 1192-1207.
[2]	WANG He, GUO Zhiting, LI Jianxi, ZHANG Jingyan, WANG Lei, ZHANG Kang, SUN Jiwen, SHANG Xiaofen, MA Yonghua. Effect of Radix dichroa Powder on the Control of Eimeria tenella Infection in Chick at Different Developmental Stages [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 1278-1289.
[3]	WEI Miaoyi, WU Shihai, YANG Fulin, YU Chenyun, SUN Zhigang, LIU Xinyuan, XU Yuanyuan, LIANG Bingbing, LI Fuhuang, SUN Hong, LIU Xiaoye, DONG Hong. Clinical Efficacy of Herbal Gentian Combat Trichomonas pigeon [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(2): 785-796.
[4]	GUO Dawei, HOU Silu, CHI Yujia, YU Feike, YU Xiaohan, DENG Qian, XIAO Chuanming, LIU Xiaoye, DONG Hong. Clinical Research of Qiying Decoction and Zigan Decoction on Promoting Reproductive Performance of Sows and Growth Performance of Weaned Piglets [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1994-2004.
[5]	LI Huaming, XIANG Wei, LU Wenbing, LIU Feng, LEI Liancheng, ZHANG Fuxian. Pathogenicity and Drug Sensitivity Analysis of a Porcine Klebsiella pneumoniae Type ST-35 [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(12): 4356-4366.
[6]	WANG Zilin, TANG Ziheng, LIN Zening, LIU Wenzi, LIU Rong, ZHANG Jiahui, SHEN Xiangguang. Effect of Traditional Chinese Medicine Compound Synephrine on the Detection of β-agonists Using Colloidal Gold Immunochromatographic Assay [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(12): 3675-3680.
[7]	ZHANG Xin-yu, LIU Bo, LUO Jun-rong, XU Yang, SHANG Han-le, YANG Shi-tang, SONG Xiao-zhen. Effects of Chinese Medicine Prescriptions on Production Performance, Physiological and Biochemical Indexes of Beef Cattle under Heat Stress [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(3): 620-628.
[8]	DU Yi-nan, XIN Xian-meng, ZHAO Jian-shuai, ZHANG Jin, HUANG Shuang, GUO Ya-ru, ZHANG Ying-li, XU Yong-ping. The Study of Mathematic Model of Progesterone on the Regulation of Duodenal Myoelectric Activity of Female Rabbit [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(12): 2715-2722.
[9]	DU Yi-nan, GUO Ya-ru, ZHAO Jian-shuai, ZHANG Jin, XIN Xian-meng, MA Yi-jia, HE Xue-min, XU Yong-ping. The Effect of Estrogen on the Regulation of Duodenal Myoelectric Activity of Female Rabbit [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(10): 2268-2275.
[10]	ZHANG Juan, WANG Jun-wu, HAN Ye-chen, YUN Shi-yu, WU Hai-ping, ZHAO Dong-dong, WEN Shuang, WANG Zhuo, CHENG Jia, SU Xiao-fei, ZHU Yu-bo, SUN Yao-gui, WANG Wen-kui, LI Hong-quan, DUAN Zhi-bian. The Effect of the Compound Traditional Chinese Medicine on Endothelium Derived Multiplication Factor in Lung of Broilers with Ascites Syndrome [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(1): 174-184.
[11]	HAN Ye-chen, ZHANG Juan, WANG Jun-wu, YUN Shi-yu, WU Hai-ping, WEN Shuang, ZHAO Dong-dong, WANG Zhuo, SU Xiao-fei, ZHU Yu-bo, CHENG Jia, SUN Yao-gui, WANG Wen-kui, LI Hong-quan, DUAN Zhi-bian. The Effect of the Compound Recipe of the Traditional Chinese Medicine on Collagen in Liver of Broilers with Ascites Syndrome [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(11): 2310-2317.
[12]	HAN Ye-chen，SU Xiao-fei，WANG Jun-wu，ZHANG Juan，ZHU Yu-bo，CHENG Jia，YUN Shi-yu，SUN Yao-gui，WANG Wen-kui，LI Hong-quan，DUAN Zhi-bian. The Effect and Mechanism of the Compound Recipe of the Traditional Chinese Medicine on NO，ET-1 in Lung of Broiler with Ascites Syndrome [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(6): 1055-1062.
[13]	NING Guan-bao，NIU Yi-ru，ZHANG Ding，LI Hong-quan，MA Hai-li，GAO Rong-kun，HAO Wei-fang，GAO Wen-wei，ZHAO Yu-jun，GAO Shi-min，LI Gui-lan，LI Jian-hui，YAN Fang，TIAN Wen-xia. Studies on the Drug Resistance of Chicken Isolated Escherichia coli and Role of Traditional Chinese Medicines in the Drug Resistance Elimination [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(6): 1018-1025.
[14]	DONG Shu-wei，ZHANG Shi-dong，WANG Dong-sheng，WANG Hui，MIAO Xiao-lou，YAN Zuo-ting，YANG Zhi-qiang. Efficacy of Chinese Medicine on Endometritis in Cow：a Systematic Review and Meta-analysis [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(11): 2085-2096.
[15]	LIU Xiao-xi，LIU Ming-jiang，YIN Peng，HE Sha-sha，CHONG Xin-lu，LIU Feng-hua，XU Jian-qin. A Review on the Traditional Chinese Veterinary Medicine Network Pharmacology [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(6): 856-862.