Wnt/β-连环蛋白信号通路在哺乳动物毛囊发育中的调控作用

doi:10.11843/j.issn.0366-6964.2019.11.002

Abstract

Abstract: Hair follicles are important accessory structures on mammalian skin and are the most important organs for controlling hair growth. Development of hair follicle mainly includes hair follicle morphogenesis and hair follicle regeneration.The Wnt/β-catenin signaling pathway plays an important role in the development of hair follicle and has received extensive attention from scholars and research institutions. In this paper, regulating mechanisms and intranuclear activation of Wnt/β-catenin were reviewed. Regulating mechanisms of Wnt/β-catenin on hair follicle morphogenesis and hair follicle regeneration, regulatory roles of osteoblast inhibitory factor (Dkk) and a large number of nutrients on development of hair follicle in mammals were also summarized. The current review will provide references for the regulation of mammalian hair follicle development by Wnt/β-catenin signaling pathway.

CLC Number:

S852.21

LI Fan, CHEN Xiaoyang, YANG Guoyu, LI Fuchang. The Regulatory Role of Wnt/β-catenin Signaling Pathway in the Development of Mammalian Hair Follicles[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(11): 2186-2194.

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The Regulatory Role of Wnt/β-catenin Signaling Pathway in the Development of Mammalian Hair Follicles

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