食物摄入与下丘脑能量平衡

doi:10.11843/j.issn.0366-6964.2021.07.003

Abstract

Abstract: Energy balance refers to the process of balance between energy intake and energy expenditure, and only when the body is in energy balance can it keep normal life activities. There are numbers of feeding related nucleus in the hypothalamus, which form a complex and sophisticated neural network, and hypothalamus acts as the key junction of neural and endocrine regulation on energy balance. This review will discuss the function of hypothalamus in food intake and energy balance from the nucleus, neuropeptide, neural projection and peripheral hormones that affect the energy balance of hypothalamus.

Key words: energy balance, hypothalamus, neuropeptide, peripheral hormones

CLC Number:

S852.21

MA Tianying, LI Yilin, DONG Xinyue, SI Rongrong, BAI Xue, WANG Zixu, CHEN Yaoxing, CAO Jing. Food Intake and Hypothalamic Energy Balance[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(7): 1789-1799.

References 34

[1]	PERBONI S, VIGNONI M, INUI A. Chapter 154:NPY[M]//KASTIN A J. Handbook of Biologically Active Peptides. 2th ed. Salt Lake City:Academic Press, 2013:1143-1148.
[2]	WEN S, WANG C X, GONG M, et al. An overview of energy and metabolic regulation[J]. Sci China Life Sci, 2019, 62(6):771-790.
[3]	YOUSEFVAND S, HAMIDI F. The role of ventromedial hypothalamus receptors in the central regulation of food intake[J]. Int J Pept Res Ther, 2021, 27(1):689-702.
[4]	WATERSON M J, HORVATH T L. Neuronal regulation of energy homeostasis:beyond the hypothalamus and feeding[J]. Cell Metab, 2015, 22(6):962-970.
[5]	LOH K, HERZOG H, SHI Y C. Regulation of energy homeostasis by the NPY system[J]. Trends Endocrinol Metab, 2015, 26(3):125-135.
[6]	WANG P T Q, LOH K H, WU M, et al. A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue[J]. Nature, 2020, 583(7818):839-844.
[7]	BI S, KIM Y J, ZHENG F P. Dorsomedial hypothalamic NPY and energy balance control[J]. Neuropeptides, 2012, 46(6):309-314.
[8]	POOLE E I, RUST V A, CROSBY K M. Nitric oxide acts in the rat dorsomedial hypothalamus to increase high fat food intake and glutamate transmission[J]. Neuroscience, 2020, 440:277-289.
[9]	DAVIS J F, BENOIT S C. Chapter 156:Orexin[M]//KASTIN A J. Handbook of Biologically Active Peptides. 2th ed. Salt Lake City:Academic Press, 2013:1154-1159.
[10]	MUL J D, ADAN R A H. Chapter 153:Melanocortins[M]//KASTIN A J. Handbook of Biologically Active Peptides. 2th ed. Salt Lake City:Academic Press, 2013:1135-1142.
[11]	GANTZ I, FONG T M. The melanocortin system[J]. Am J Physiol Endocrinol Metab, 2003, 284(3):E468-E474.
[12]	INHOFF T, STENGEL A, PETER L, et al. Novel insight in distribution of nesfatin-1 and phospho-mTOR in the arcuate nucleus of the hypothalamus of rats[J]. Peptides, 2010, 31(2):257-262.
[13]	KIM J D, LEYVA S, DIANO S. Hormonal regulation of the hypothalamic melanocortin system[J]. Front Physiol, 2014, 5:480.
[14]	黄梅凤, 胡芳. 下丘脑黑皮质素系统对机体能量代谢的调控[J]. 临床与病理杂志, 2016, 36(6):852-858.HUANG M F, HU F. Hypothalamic melanocortin system in the control of energy metabolism[J]. J Clin Pathol Res, 2016, 36(6):852-858. (in Chinese)
[15]	李鹏. 室旁核黑皮质素-3/4受体调控交感神经活动和脂肪传入反射[D]. 南京:南京医科大学, 2013.LI P. Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic activity and adipose afferent reflex[D]. Nanjing:Nanjing Medical University, 2013. (in Chinese)
[16]	JUNG H, HAN M J, JANG B, et al. The oligomerization mediated by the alanine 397 residue in the transmembrane domain is crucial to sydecan-3 functions[J]. Cell Signal, 2020, 69:109544.
[17]	LIEU L, CHAU D, AFRIN S, et al. Effects of metabolic state on the regulation of melanocortin circuits[J]. Physiol Behav, 2020, 224:113039.
[18]	王梦远, 王俊博, 唐致恒, 等. AgRP/NPY神经元代谢调控功能研究进展[J]. 生理科学进展, 2019, 50(1):67-75.WANG M Y, WANG J B, TANG Z H, et al. Metabolic regulatory function of AgRP/NPY neurons[J]. Progress in Physiological Sciences, 2019, 50(1):67-75. (in Chinese)
[19]	孙旸, 王鹏源, 刘霞. 摄食的神经及内分泌调节[J]. 药学实践杂志, 2016, 34(6):501-506, 521.SUN Y, WANG P Y, LIU X. Neuronal and endocrine regulation of food intake[J]. Journal of Pharmaceutical Practice, 2016, 34(6):501-506, 521. (in Chinese)
[20]	乔富强, 姚华, 董宽虎. 瘦素的生物学功能及其应用前景[J]. 四川畜牧兽医, 2003, 30(10):33-34.QIAO F Q, YAO H, DONG K H. The biological function and application foreground of leptin[J]. Sichuan Animal & Veterinary Sciences, 2003, 30(10):33-34. (in Chinese)
[21]	MYERS JR M G, GREENWALD-YARNELL M. Chapter 152:leptin[M]//KASTIN A J. Handbook of Biologically Active Peptides. 2nd ed. Salt Lake City:Academic Press, 2013:1129-1134.
[22]	WASIM M, AWAN F R, NAJAM S S, et al. Role of leptin deficiency, inefficiency, and leptin receptors in obesity[J]. Biochem Genet, 2016, 54(5):565-572.
[23]	高海明. 瘦素与胰岛素抵抗关系及运动[J]. 体育科技文献通报, 2010, 18(4):129-131.GAO H M. Relationship between leptin and insulin resistance and its adaptation to exercises[J]. Bulletin of Sport Science & Technology, 2010, 18(4):129-131. (in Chinese)
[24]	宋岳强, 左正宏, 王诚, 等. 瘦素在禽类中的研究进展[J]. 动物学杂志, 2007, 42(5):163-168.SONG Y Q, ZUO Z H, WANG C, et al. Research progress on leptin in avian[J]. Chinese Journal of Zoology, 2007, 42(5):163-168. (in Chinese)
[25]	GRAYSON B E, WOODS S C. Chapter 151-insulin[M]//KASTIN A J. Handbook of Biologically Active Peptides. 2th ed. Salt Lake City:Academic Press, 2013:1123-1128.
[26]	MARGETIC S, GAZZOLA C, PEGG G G, et al. Leptin:a review of its peripheral actions and interactions[J]. Int J Obes Relat Metab Disord, 2002, 26(11):1407-1433.
[27]	郭展宏, 臧璞, 邵加庆. 胃饥饿素与糖脂代谢、能量平衡及肥胖的关系[J]. 中国糖尿病杂志, 2019, 27(4):316-320.GUO Z H, ZANG P, SHAO J Q. Ghrelin with glucose, lipid metabolism, energy balance and obesity[J]. Chinese Journal of Diabetes, 2019, 27(4):316-320. (in Chinese)
[28]	孙晓宇, 郭汝涛, 张洪涛, 等. 胃肠激素与肥胖关系的研究进展[J]. 现代生物医学进展, 2015, 15(14):2786-2789.SUN X Y, GUO R T, ZHANG H T, et al. Research on correlations of gastrointestinal hormones and calorigenic nutrients for obesity[J]. Progress in Modern Biomedicine, 2015, 15(14):2786-2789. (in Chinese)
[29]	RAGHAY K, AKKI R, BENSAID D, et al. Ghrelin as an anti-inflammatory and protective agent in ischemia/reperfusion injury[J]. Peptides, 2020, 124:170226.
[30]	CANPOLAT S, AYDIN M, YASAR A, et al. Effects of pinealectomy and exogenous melatonin on immunohistochemical ghrelin staining of arcuate nucleus and serum ghrelin leves in the rat[J]. Neurosci Lett, 2006, 410(2):132-136.
[31]	AL-MASSADI O, HEPPNER K M, NOGUEIRAS R, et al. Chapter 148:Ghrelin[M]//KASTIN A J. Handbook of Biologically Active Peptides. 2nd ed. Salt Lake City:Academic Press, 2013:1104-1110.
[32]	TIMPER K, BRVNING J C. Hypothalamic circuits regulating appetite and energy homeostasis:pathways to obesity[J]. Dis Model Mech, 2017, 10(6):679-689.
[33]	YOUSEFVAND S, HAMIDI F. Role of paraventricular nucleus in regulation of feeding behaviour and the design of intranuclear neuronal pathway communications[J]. Int J Pept Res Ther, 2020, 26(3):1231-1242.
[34]	ALONGE K M, D'ALESSIO D A, SCHWARTZ M W, et al. Brain control of blood glucose levels:implications for the pathogenesis of type 2 diabetes[J]. Diabetologia, 2021, 64(1):5-14.

Food Intake and Hypothalamic Energy Balance

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 34

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	CAO Jianhua, YANG Baigao, ZHANG Peipei, FENG Xiaoyi, ZHANG Hang, YU Zhou, NIU Yifan, HAO Haisheng, DU Weihua, ZHU Huabin, YANG Ling, ZHAO Xueming. Mechanisms of Negative Energy Balance Affects Follicular Development in Dairy Cattle [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 22-30.
[2]	YANG Chengying, WANG Kai, HUANG Ziqing, LIN Hailan, WANG Naixiu, LI Yuhang, LIU Yanqing, LIU Yuxuan, ZHU Yan, HE Daoling, CHEN Hongyue, GAN Ling. Study on the Inhibitory Effect of Chito-oligosaccharide on Oxidative Stress inHippocampus of Piglets and Its Mechanism [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 744-756.
[3]	LIU Jie, CONG Wei, ZHAO Mindie, ZHAO Ruqian. Expression of GR and FKBP5 in Hippocampus and Hypothalamus of Arbor Acres and Rugao Yellow Broiler Chickens and Its Relationship with Stress Sensitivity [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4766-4776.
[4]	FENG Xiaoyi, HAO Haisheng, DU Weihua, ZHU Huabin, CUI Kai, ZHAO Xueming. Progress in Mechanism of Reduced Fertility in Dairy Cows due to Negative Energy Balance [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4050-4060.
[5]	YANG Chengying, LIN Hailan, HUANG Ziqing, WANG Naixiu, WANG Kai, GAN Ling. Effects and Mechanisms of Exogenous Neuropeptide CART on Oxidative Stress in Hippocampal Neurons [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(4): 1231-1240.
[6]	QIU Kai,CHANG Xinyu,CHE Yanzhuo,WANG Jing,ZHANG Haijun,QI Guanghai,WU Shugeng. Research Advances on Low-Protein Diets of Laying Hens [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(10): 3305-3315.
[7]	AN Xiuxiu, LIU Lin, XU Yuwei, WU Yalin, LUO Mengyun, WEI Xueliang. Effect of 1.8 GHz Microwave on the Structure of Hypothalamus in Mice [J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(3): 612-619.
[8]	YANG Yue, GUO Zeming, HAN Haoshu, LI Weitian, GAO Ting, WANG Xintong, CHEN Yaoxing. Effect of Acute Sleep Deprivation on Melatonin Level of Plasma and Clock Gene Expression of Hypothalamus in Mice [J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(10): 2609-2612.
[9]	SHI Huibin, WANG Yuqin, ZHANG Xiaohui, WU Zhibo, YANG Fang. Selection of Related Signaling Pathways and Candidate Genes Related to Hypothalamus Tissue Reproduction in Goats Based on Transcriptome Sequencing Data [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(7): 1380-1395.
[10]	WANG Wenli, ZHANG Yuxian, YUAN Zhanhang, WANG Zixu, DONG Yulan, CHEN Yaoxing. Effect of Photoperiods on Distribution and Expression of Melatonin Receptors in Hypothalamus-Pituitary-Ovary Axis in Female Rabbits [J]. Acta Veterinaria et Zootechnica Sinica, 2019, 50(12): 2518-2528.
[11]	LIU Xue-lian, ZHANG Pan-pan, TIAN Fang-yuan, LI Zhun, LI Zhuan-jian, HAN Rui-li, SUN Gui-rong, JIANG Rui-rui, LIU Xiao-jun, KANG Xiang-tao, TIAN Ya-dong. Research of Visfatin Regulating Chicks Feed Intake Based on GC-MS Metabolomics [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(7): 1251-1259.
[12]	SHEN Xiang-hua, PAN Deng, FAN Kui-kui, LI Qiang, LI Ting, DU Chen-guang. Ghrelin Mediate Female Mice Food Intake via Affecting on Estrogen Receptor-alpha Neuron in Arcuate Nucleus [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(12): 2399-2406.
[13]	HAN Wei，SHENG Zhong-wei, ZHU Yun-fen， LI Guo-hui，WANG Hong-zhi， ZHANG Hui-yong，YIN Jian-mei，SU Yi-jun，WANG Ke-hua，ZOU Jian-min. Analysis of Hypothalamic microRNA Expression Profile during Chicken Puberty Onset [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(1): 23-30.
[14]	HAN Wei，SU Yi-jun，ZHU Yun-fen，LI Guo-hui，ZHANG Hui-yong，YIN Jian-mei，WANG Ke-hua，ZOU Jian-min. Analysis on Changes of Hypothalamic c-Myc/LIN28B/let-7a Pathway Transcription during Puberty Onset in Wenchang Chicken [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(4): 709-715.
[15]	TAO Jin-zhong，GUO Yan-sheng. Study on the Plasma Metabolism Using ¹H-NMR in Postpartum Cows [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(1): 198-206.