表观遗传学在羊遗传育种中的研究进展

doi:10.11843/j.issn.0366-6964.2025.08.001

Abstract

Abstract:

The skin, wool, milk and meat of sheep and goats can be processed for people to produce livestock products with important economic benefits and loved by the people, prompting the demand for sheep and goats continue to increase. Sheep and goats farming occupies an important position in China′s animal husbandry industry. Maintaining the superior performance of the breed, phenotypic breeding and genotypic breeding provide effective and accurate data support for scientific selection and breeding, and through the traditional and emerging technology means of breeding to improve the production performance of the breed, thus improving the production traits of sheep and goats to increase their economic benefits. Epigenetics is a sub-discipline of genetics and an emerging field of study, which is the regulation and genetic expression of genes without altering the DNA sequence. The application of high throughput sequencing technology for genetic breeding of sheep and goats continues to be enhanced at the DNA methylation, chromatin accessibility, histone modification and 3D genomic levels. It plays an important role in the study of complex economic traits in sheep and goats such as growth traits, fleece traits, reproductive traits, lipid metabolism, as well as immunity and disease, identifying relevant candidate genes, regulatory elements and their loci of action. This review summarizes the latest research status and future directions in the field of sheep and goats genetic breeding from an epigenetic perspective.

Key words: epigenetics, sheep and goats, genetic breeding

CLC Number:

LIU Can, SU Yixin, JING Xianjin, LI Wenze, YANG Lepu, WANG Ruijun, ZHANG Yanjun, WANG Zhiying, LÜ Qi, SU Rui. Research Progress of Epigenetics in Sheep and Goats Genetic Breeding[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(8): 3561-3577.

Figures/Tables 4

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研究内容 Research content	高通量检测技术 High throughput detection technology
DNA甲基化DNA methylation	WGBS、BS-Seq、RRBS、MeDIP-seq等
RNA修饰RNA modification	MeRIP-seq/m6A-seq、m6Aseq 2、msC-seq、m7G-seq、m6A-REF-seq、m6A-LAIC-seq、DART-Seq等
染色质可及性Chromatin accessibility	DNase-seq、MNase-seq、FAIRE-seq、ATAC-seq、scATAC-seq等
组蛋白修饰Histone modification	ChIP-seq、CUT&Tag、CUT&Run、DAP-seq、HiChIP等
三维基因组3D genomics	Hi-C、scHi-C、Micro-C等

物种 Species	品种 Breed	性状 Trait	调控机制 Regulation mechanism	非编码RNA ncRNA	基因 Gene	参考文献 Reference
山羊 Goat	陕北白绒山羊	绒毛性状	DNA甲基化	lnc_000374、lnc_002056	HOXC13、SOX9、SOX21、JUNB、LHX2、VDR、GATA3	[40]
	安淮山羊	脂质代谢	DNA甲基化	XLOC_960044、XLOC_767346	CACNA1E	[47]
	简州大耳羊	生长性状	RNA修饰	miR-503-5p	Ythdf2	[56]
	简州大耳羊	生长性状	RNA修饰	miR-874-3p、miR-874-3p、circRNA_0873、circRNA_0873、circRNA_1161	LAMA5、EBF3、HDAC11、CCND2	[60]
	绒山羊	绒毛性状	RNA修饰	circPAPPA	PAPPA	[63]
	内蒙古绒山羊	绒毛性状	RNA修饰	circRNA_2130、circRNA_0013、circRNA_1203、circRNA_1462、circRNA_1242、circRNA_2308、circRNA_2654、circRNA_1442	ANGEL2、APP、GKAP1、HNRNPC、PTBP3、NUCB1、SNRK、ZNF609	[65]
	辽宁绒山羊	绒毛性状	RNA修饰	circHECA	HECA	[66]
	辽宁绒山羊	绒毛性状	RNA修饰	circERCC6	ERCC6	[67]
	辽宁绒山羊	绒毛性状	RNA修饰	circRNA-ZNF638	ZNF638	[68]
	黑山羊	繁殖性状	RNA修饰	circRNA4464、circRNA1212、circRNA1213、circRNA1149、circRNA4524等	—	[74]
绵羊 Sheep	湖羊	生长性状	DNA甲基化	lncRNA	GTL2	[35]
绵羊 Sheep	小尾寒羊	绒毛性状	RNA修饰	lncRNA: MSTRG.46299-PSEN2、ENSOARG00020016306-CCND3、ENSOARG00020002712-COL2A1、ENSOARG00020008516-ERCC3	PSEN2、CCND3、COL2A1、ERCC3	[61]

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Research Progress of Epigenetics in Sheep and Goats Genetic Breeding

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