痒螨病皮肤损伤机制研究进展

doi:10.11843/j.issn.0366-6964.2025.07.010

Abstract

Abstract:

Psoroptic mange, a prevalent ecto-parasitic disease affecting domestic and wild animals globally, is primarily characterized by skin lesions. Understanding the characteristics and mechanisms underlying these skin lesions is crucial for developing novel measures against psoroptic mange. This paper systematically reviews the pathological manifestations of skin lesions in psoroptic mange, focusing on the perturbations in the skin's physical and immune barriers during disease progression. Potential factors contributing to these alterationss are discussed, including the mechanical activity of Psoroptes mites and their excretory-secretory proteins (PsoES) which can impair the skin 's physical barrier. Additionally, allergenic and other bioactive molecules within the PsoES can infiltrate the weakened physical barrier, disrupting the immune barrier and thereby accelerating the onset and and progression of skin damage. The objective of this review is to provide insights and directional guidance for the development of novel anti-mite therapeutics, ultimately aiming to provide new perfectives on the prevention and control of psoropic mange.

Key words: psoroptic mange, skin lesion, causative factors of skin lesion

CLC Number:

S855.9

FAN Jie, GU Xiaobin. Advances in Research on Skin Lesion of Psoroptic Mange[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(7): 3142-3151.

Figures/Tables 3

References 66

1	KIRKWOOD A C . History, biology and control of sheep scab[J]. Parasitol Today, 1986, 2 (11): 302- 307.
2	MAZET J A K , BOYCE W M , MELLIES J , et al. Exposure to Psoroptes sp. mites is common among bighorn sheep (Ovis canadensis) populations in California[J]. J Wildlife Dis, 1992, 28 (4): 542- 547.
3	SINCLAIR A N , FILAN S J . Lipid ingestion from sheep epidermis by Psoroptes ovis (Acari: Psoroptidae)[J]. Vet Parasitol, 1989, 31, 149- 164.
4	孔繁瑶. 家畜寄生虫病学[M]. 北京: 中国农业大学出版社, 1997: 264.
	KON F Y . Veterinary parasitology[M]. Beijing: China Agricultural University Press, 1997: 264.
5	陈志蓉. 绵羊痒螨的生物学特性及其危害与防制研究[D]. 杨凌: 西北农林科技大学, 2008.
	CHEN Z R. Study on the biological characteristics, harmfulness and control methods of psoroptes ovis. [D]. Yangling: Northwest Agriculture and Forestry University, 2008. (in Chinese)
6	SIEGFRIED E , OCHS H , DEPLAZES P . Clinical development and serological antibody responses in sheep and rabbits experimentally infested with Psoroptes ovis and Psoroptes cuniculi[J]. Vet Parasitol, 2004, 124 (1-2): 109- 124.
7	CHEN Z , CLAEREBOUT E , CHIERS K , et al. Dermal immune responses against Psoroptes ovis in two cattle breeds and effects of anti-inflammatory dexamethasone treatment on the development of psoroptic mange[J]. Vet Res, 2021, 52, 1- 11.
8	ZHANG C , GU X , CHEN Y , et al. Molecular characterization of four novel serpins in Psoroptes ovis var. cuniculi and their implications in the host-parasite interaction[J]. Int J Biol Macromol, 2021, 182, 1399- 1408.
9	MITCHELL S , CARSON A . Sheep scab-the importance of accurate diagnosis[J]. Vet Rec, 2019, 185 (4): 105.
10	SARRE C. Psoroptes ovis mange in Belgian Blue cattle: How to approach a multifactorial problem?[D]. Ghent University, 2015.
11	VAN DEN BROEK A H M , ELSE R W , HUNTLEY J F , et al. Early innate and longer-term adaptive cutaneous immune inflammatory responses during primary infestation with the sheep scab mite, Psoroptes ovis[J]. J Comp Pathol, 2004, 131 (4): 318- 329.
12	LIM K M . Skin epidermis and barrier function[J]. Int J Mol Sci, 2021, 22 (6): 3035.
13	LEFÈVRE-UTILE A , BRAUN C , HAFTEK M , et al. Five functional aspects of the epidermal barrier[J]. Int J Mol Sci, 2021, 22 (21): 11676.
14	GU X , GE Y , WANG Y , et al. Macrophage migration inhibitory factor in Psoroptes ovis: molecular characterization and potential role in eosinophil accumulation of skin in rabbit and its implication in the host-parasite interaction[J]. Int J Mol Sci, 2023, 24 (6): 5985.
15	STOECKLI M R , MCNEILLY T N , FREW D , et al. The effect of Psoroptes ovis infestation on ovine epidermal barrier function[J]. Vet Res, 2013, 44, 1- 11.
16	ZHANG L . Keratins in skin epidermal development and diseases[M]. Keratin. IntechOpen, 2018.
17	PONDELJAK N , LUGOVIĆ-MIHIĆ L , TOMIĆ L , et al. Key factors in the complex and coordinated network of skin keratinization: their significance and involvement in common skin conditions[J]. Int J Mol Sci, 2023, 25 (1): 236.
18	FERNANDES M T P , DOS SANTOS J F , FREITAS B L , et al. Reporter system controlled by the involucrin promoter as a tool to follow epidermal differentiation[J]. Biochimie, 2022, 201, 33- 42.
19	KIM Y , LIM K M . Skin barrier dysfunction and filaggrin[J]. Arch Pharm Res, 2021, 44 (1): 36- 48.
20	AL-KHAFAJI Z , BRITO S , BIN B H . Zinc and zinc transporters in dermatology[J]. Int J Mol Sci, 2022, 23 (24): 16165.
21	WANG S , SONG R , WANG Z , et al. S100A8/A9 in Inflammation[J]. Front Immunol, 2018, 9, 1298.
22	XIA P , JI X , YAN L , et al. Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity[J]. Immunology, 2024, 171 (3): 365- 376.
23	NAGATA M , NAKAGOME K , SOMA T . Mechanisms of eosinophilic inflammation[J]. Asia Pacific Allergy, 2020, 10 (2): e14.
24	YOUNG J D E , PETERSON C G B , VENGE P , et al. Mechanism of membrane damage mediated by human eosinophil cationic protein[J]. Nature, 1986, 321 (6070): 613- 616.
25	NETTIS E , PANNOFINO A , D'APRILE C , et al. Clinical and aetiological aspects in urticaria and angio-oedema[J]. Br J Dermatol, 2003, 148 (3): 501- 506.
26	HENDERSON W R . The role of leukotrienes in inflammation[J]. An Int Med, 1994, 121 (9): 684- 697.
27	BRANCO A C C C , YOSHIKAWA F S Y , PIETROBON A J , et al. Role of histamine in modulating the immune response and inflammation[J]. Mediators inflamm, 2018, 2018 (1): 9524075.
28	MATHIESON B R F , LEHANE M J . Ultrastructure of the alimentary canal of the sheep scab mite, Psoroptes ovis (Acari: Psoroptidae)[J]. Vet Parasitol, 2002, 104 (2): 151- 166.
29	DEN BROEK V , HUNTLEY , MACHELL , et al. Cutaneous and systemic responses during primary and challenge infestations of sheep with the sheep scab mite, Psoroptes ovis[J]. Parasite Immunol, 2000, 22 (8): 407- 414.
30	YOSHIDA K , ITO M , SATO N , et al. Extracellular ATP augments antigen-induced murine mast cell degranulation and allergic responses via P2X4 receptor activation[J]. J Immunol, 2020, 204 (12): 3077- 3085.
31	NUMATA T , HARADA K , NAKAE S . Roles of mast cells in cutaneous diseases[J]. Front Immunol, 2022, 13, 923495.
32	LEHMAN H K , SEGAL B H . The role of neutrophils in host defense and disease[J]. J Allerg Clin Immunol, 2020, 145 (6): 1535- 1544.
33	VAN DER BROEK A H M , HUNTLEY J F , MACKELLAR A , et al. Characterization of lesional infiltrates of dendritic cells and T cell subtypes during primary infestation of sheep whit Psoroptes ovis, the sheep scab mite[J]. Vet Immunol Immunophatol, 2005, 105, 141- 150.
34	SARRE C , GONZÁLEZ-HERNÁNDEZ A , VAN COPPERNOLLE S , et al. Comparative immune responses against Psoroptes ovis in two cattle breeds with different susceptibility to mange[J]. Vet Res, 2015, 46, 1- 10.
35	SHAMJI M H , VALENTA R , JARDETZKY T , et al. The role of allergen-specific IgE, IgG and IgA in allergic disease[J]. Allergy, 2021, 76 (12): 3627- 3641.
36	SCHNELL A , LITTMAN D R , KUCHROO V K . TH17 cell heterogeneity and its role in tissue inflammation[J]. Nat Immunol, 2023, 24 (1): 19- 29.
37	NAKAYAMA T , HIRAHARA K , ONODERA A , et al. Th2 cells in health and disease[J]. Ann Rev Immunol, 2017, 35, 53- 84.
38	BURGESS S T G , FREW D , NUNN F , et al. Transcriptomic analysis of the temporal host response to skin infestation with the ectoparasitic mite Psoroptes ovis[J]. BMC Genom, 2010, 11, 1- 28.
39	HIRANO T . IL-6 in inflammation, autoimmunity and cancer[J]. Int Immunol, 2021, 33 (3): 127- 148.
40	HAMILTON J A . GM-CSF in inflammation[J]. J Exp Med, 2020, 217 (1): e20190945.
41	HAJISHENGALLIS G , REIS E S , MASTELLOS D C , et al. Novel mechanisms and functions of complement[J]. Nat Immunol, 2017, 18 (12): 1288- 1298.
42	MAPSTONE S C , BEASLEY A , WALL R . Structure and function of the gnathosoma of the mange mite, Psoroptes ovis[J]. Med Vet Entomol, 2002, 16 (4): 378- 385.
43	WALL R , SHEARER D . Veterinary ectoparasites: biology, pathology and control[M]. John Wiley & Sons, 2008.
44	BERRIATUA E , FRENCH N P , BROSTER C E , et al. Effect of infestation with Psoroptes ovis on the nocturnal rubbing and lying behaviour of housed sheep[J]. App Anim Behav Sci, 2001, 71 (1): 43- 55.
45	WIMALASENA N K , MILNER G , SILVA R , et al. Dissecting the precise nature of itch-evoked scratching[J]. Neuron, 2021, 109 (19): 3075- 3087. e2.
46	VAN DEN BROEK A H M , HUNTLEY J F , HALLIWELL R E W , et al. Cutaneous hypersensitivity reactions to Psoroptes ovis and Der p 1 in sheep previously infested with P. ovis—the sheep scab mite[J]. Vet Immunol Immunopathol, 2003, 91 (2): 105- 117.
47	MATTHES H F , HARRISON G B L , SHAW R J , et al. Cross-reacting antibodies to Sarcoptes suis, Chorioptes bovis and Notoedres cati and anti-P. ovis IgE in sera from sheep infested naturally with Psoroptes ovis[J]. Int J Parasitol, 1996, 26 (4): 437- 444.
48	KENYON F , WELSH M , PARKINSON J , et al. Expressed sequence tag survey of gene expression in the scab mite Psoroptes ovis-allergens, proteases and free-radical scavengers[J]. Parasitology, 2003, 126 (5): 451- 460.
49	HE M L , XU J , HE R , et al. Preliminary analysis of Psoroptes ovis transcriptome in different developmental stages[J]. Parasite Vector, 2016, 9, 1- 12.
50	BURGESS S T G , MARR E J , BARTLEY K , et al. A genomic analysis and transcriptomic atlas of gene expression in Psoroptes ovis reveals feeding-and stage-specific patterns of allergen expression[J]. BMC Genom, 2019, 20, 1- 23.
51	NISBET A J , MACKELLAR A , MCLEAN K , et al. Eukaryotic expression of recombinant Pso o 1, an allergen from Psoroptes ovis, and its localization in the mite[J]. Parasitology, 2007, 134 (1): 83- 89.
52	LEE A J , HUNTLEY J , VAN DEN BROEK A , et al. Expression and characterisation of a Psoroptes ovis glutathione S-transferase[J]. Vet Parasitol, 2002, 105 (1): 49- 63.
53	黄翠锐, 郝桂英, 周宇, 等. 绵羊痒螨重组精氨酸激酶诱导兔皮肤嗜酸性粒细胞的聚集[J]. 畜牧兽医学报, 2023, 54 (5): 2186- 2194. doi: 10.11843/j.issn.0366-6964.2023.05.038
	HUANG C R , HAO G Y , ZHOU Y , et al. Recombinant arginine kinase of Psoroptes ovis induces cutaneous eosinophil recruitment in rabbit[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54 (5): 2186- 2194. doi: 10.11843/j.issn.0366-6964.2023.05.038
54	LEE A J , MACHELL J , VAN DEN BROEK A H M , et al. Identification of an antigen from the sheep scab mite, Psoroptes ovis, homologous with house dust mite group I allergens[J]. Parasite Immunol, 2002, 24 (8): 413- 422.
55	MCNAIR C M , BILLINGSLEY P F , NISBET A J , et al. Feeding-associated gene expression in sheep scab mites (Psoroptes ovis)[J]. Vet Res, 2010, 41 (2): 16.
56	KENYON F , KNOX D . The proteinases of Psoroptes ovis, the sheep scab mite—their diversity and substrate specificity[J]. Vet Parasitol, 2002, 105 (4): 317- 325.
57	NISBET A J , BILLINGSLEY P F . Hydrolytic enzymes of Psoroptes cuniculi (Delafond)[J]. Insect biochemistry and molecular biology, 1999, 29 (1): 25- 32.
58	郑友乐, 陈宇航, 谢跃, 等. 绵羊痒螨巨噬细胞迁移抑制因子重组蛋白对兔外周血单个核细胞Th1/Th2型和Th17/Treg型特征因子表达的影响[J]. 畜牧兽医学报, 2020, 51 (3): 594- 601. doi: 10.11843/j.issn.0366-6964.2020.03.019
	ZHENG Y L , CHEN Y H , XIE Y , et al. The effects of recombinant macrophage migration inhibitory factor of Psoroptes ovis on the characteristic molecules of Th1/Th2 and Th17/Treg Type immune responses in rabbits peripheral blood mononuclear cells in vitro[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51 (3): 594- 601. doi: 10.11843/j.issn.0366-6964.2020.03.019
59	黄翠锐. 绵羊痒螨重组原肌球蛋白对角质形成细胞生物学功能的影响及其致敏性评价[D]. 成都: 四川农业大学, 2023.
	HUANG C R. Effect of recombinant tropomyosin of Psoroptes ovis on the biological function in keractinocyte andevaluation of its allergenicity[D]. Chengdu: Sichuan Agricultural University, 2023. (in Chinese)
60	田焱. 绵羊痒螨重组丝氨酸蛋白酶抑制剂的抗炎活性研究[D]. 成都: 四川农业大学, 2024.
	TIAN Y. Anti-inflammation activity study on recombinant serpins of Psoroptes ovis[D]. Chengdu: Sichuan Agricultural University, 2024. (in Chinese)
61	DAMEN M , WIRTZ L , SOROKA E , et al. High proliferation and delamination during skin epidermal stratification[J]. Nat Commun, 2021, 12 (1): 3227.
62	COCKBURN K , ANNUSVER K , GONZALEZ D G , et al. Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer[J]. Nat Cell Biol, 2022, 24 (12): 1692- 1700.
63	CHEN Y Y , LEE Y H , WANG B J , et al. Skin damage induced by zinc oxide nanoparticles combined with UVB is mediated by activating cell pyroptosis via the NLRP3 inflammasome-autophagy-exosomal pathway[J]. Particle Fibre Toxicol, 2022, 19, 1- 22.
64	VAN DEN BROEK A H , HUNTLEY J F . Sheep scab: the disease, pathogenesis and control[J]. J Comp Pathol, 2003, 128 (2-3): 79- 91.
65	VAN LOO G , BERTRAND M J M . Death by TNF: a road to inflammation[J]. Nat Rev Immunol, 2023, 23 (5): 289- 303.
66	JOSHI V , DIMRI U , GOPALAKRISHNAN A , et al. Porcine scabies induces marked apoptosis, increased pro-inflammatory cytokines IL-1, TNF-α and shedding of ICAM-1[J]. Parasite Immunol, 2021, 43 (12): e12878.

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Advances in Research on Skin Lesion of Psoroptic Mange

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