非洲猪瘟病毒结构蛋白与宿主蛋白相互作用研究进展

doi:10.11843/j.issn.0366-6964.2025.01.009

Abstract

Abstract:

African swine fever (ASF) is a highly contagious disease characterized by severe bleeding in both domestic pigs and various wild boars caused by infection with the African swine fever virus (ASFV). The global pig breeding industry has suffered significant economic losses due to the high morbidity and mortality rates associated with ASF. ASFV contains over 150 different proteins, with its structural proteins playing a crucial role in facilitating the virus's attachment to and entry into host cells, as well as in the replication, assembly, and release of new viral particles. Research has demonstrated that these viral structural proteins can enhance virus invasion and replication, impact viral virulence, and counteract the host immune response through interactions with host proteins. This review summarizes the interactions between ASFV structural proteins and host proteins, along with their underlying mechanisms, in order to contribute to the understanding of ASFV pathogenesis and the development of strategies for its prevention and treatment.

Key words: African swine fever virus (ASFV), structural protein, host protein, protein-protein interaction

CLC Number:

S852.659.1

ZHANG Su, SUN Lifang, LI Lanlan, WU Linjiao, CHEN Leiqing, WU Yunkun. Research Progress on the Interactions of African Swine Fever Virus Structural Proteins with Host Proteins[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(1): 95-106.

Figures/Tables 3

Fig. 1

Fig. 2

Table 1

Interaction between ASFV structural proteins and host proteins"

病毒蛋白 Viral protein	蛋白类别 Protein categories	编码基因 Coding gene	互作宿主蛋白 Interacting host proteins	互作机制 Interaction mechanism	参考文献 Reference
P30	内囊膜蛋白 Inner envelopeprotein	CP204L	hn-RNP-K、DAB2等	影响正常核质运输；吸附宿主细胞、释放成熟病毒粒子；激活MAPK通路；抑制STATI磷酸化等 Affects normal nucleoplasmic transport; adsorbs host cells, releases mature viral particles; activates MAPK pathway; inhibits STATI phosphorylation, etc.	[27, 38]
CD2V	外囊膜蛋白 Outer envelopeprotein	EP402R	AP-1、CSF2RA、HIP-55	利用网格蛋白进行迁移；影响细胞内吞或蛋白质运输；激活JAK2-STAT3通路 Migration using lattice proteins; affects endocytosis or protein transport; activates JAK2-STAT3 pathway	[23, 49, 57]
P54	内囊膜蛋白 Inner envelopeprotein	E183L	DLC8	利用微管动力蛋白运输，激活caspase-9和caspase-3，诱导细胞凋亡 Induction of apoptosis by activation of caspase-9 and caspase-3 using microtubule dynamin transport	[61]
P72	衣壳蛋白 Capsid protein	B646L	OAS1	泛素化P72蛋白；抑制avSG的产生 Ubiquitination of P72 protein; inhibition of avSG production	[65]
P17	内囊膜蛋白 Inner envelope protein	D117L	STING、TOMM70	负调控cGAS-STING信号通路；促使线粒体自噬 Negative regulation of the cGAS-STING signaling pathway; Promotes mitochondrial autophagy	[67-68]
P14.5	衣壳蛋白 Capsid protein	E120R	IRF3、Kinesin等	干扰IRF3的磷酸化和Ⅰ型干扰素的生成；介导成熟的病毒粒子离开病毒工厂进入胞浆膜 Interferes with IRF3 phosphorylation and type Ⅰ interferon production; mediates the exit of mature viral particles from the viral factory into the plasma membrane	[69-70]
P11.5	衣壳蛋白 Capsid protein	A137R	TANK结合激酶	降解TANK，阻断INF-β的产生 Degradation of TANK and blocking of INF-β production	[72]

Table 1

References 72

1	DIXON L K , CHAPMAN D A G , NETHERTON C L , et al. African swine fever virus replication and genomics[J]. Virus Res, 2013, 173 (1): 3- 14. doi: 10.1016/j.virusres.2012.10.020
2	PENRITH M L , VOSLOO W , JORI F , et al. African swine fever virus eradication in Africa[J]. Virus Res, 2013, 173 (1): 228- 246. doi: 10.1016/j.virusres.2012.10.011
3	LIU Y J , ZHANG X H , QI W B , et al. Prevention and control strategies of african swine fever and progress on pig farm repopulation in China[J]. Viruses, 2021, 13 (12): 2552. doi: 10.3390/v13122552
4	张依玲, 易文毅, 肖静, 等. 非洲猪瘟的流行现状及防控措施[J]. 猪业科学, 2023, 40 (12): 90- 92. doi: 10.3969/j.issn.1673-5358.2023.12.031
	ZHANG Y L , YI W Y , XIAO J , et al. Epidemiology of African swine fever and preventive and control measures[J]. Swine Industry Science, 2023, 40 (12): 90- 92. doi: 10.3969/j.issn.1673-5358.2023.12.031
5	ZHOU X T , LI N , LUO Y Z , et al. Emergence of African swine fever in China, 2018[J]. Transbound Emerg Dis, 2018, 65 (6): 1482- 1484. doi: 10.1111/tbed.12989
6	GALINDO I , CUESTA-GEIJO M A , HLAVOVA K , et al. African swine fever virus infects macrophages, the natural host cells, via clathrin- and cholesterol-dependent endocytosis[J]. Virus Res, 2015, 200, 45- 55. doi: 10.1016/j.virusres.2015.01.022
7	ALEJO A , MATAMOROS T , GUERRA M , et al. A proteomic atlas of the African swine fever virus particle[J]. J Virol, 2018, 92 (23): e01293- 18.
8	朱利敏, 邹兴启, 赵启祖. 非洲猪瘟病毒多样性[J]. 病毒学报, 2021, 37 (3): 719- 725.
	ZHU L M , ZOU X Q , ZHAO Q Z . Diversity of African swine fever virus[J]. Chinese Journal of Virology, 2021, 37 (3): 719- 725.
9	JANCOVICH J K , CHAPMAN D , HANSEN D T , et al. Immunization of pigs by DNA prime and recombinant vaccinia virus boost to identify and rank African swine fever virus immunogenic and protective proteins[J]. J Virol, 2018, 92 (8): e02219- 17.
10	SÁNCHEZ E G , QUINTAS A , NOGAL M , et al. African swine fever virus controls the host transcription and cellular machinery of protein synthesis[J]. Virus Res, 2013, 173 (1): 58- 75. doi: 10.1016/j.virusres.2012.10.025
11	ALCARAZ C , DE DIEGO M , PASTOR M J , et al. Comparison of a radioimmunoprecipitation assay to immunoblotting and ELISA for detection of antibody to African swine fever virus[J]. J Vet Diagn Invest, 1990, 2 (3): 191- 196. doi: 10.1177/104063879000200307
12	OH T , DO D T , LAI D C , et al. Chronological expression and distribution of African swine fever virus p30 and p72 proteins in experimentally infected pigs[J]. Sci Rep, 2022, 12 (1): 4151. doi: 10.1038/s41598-022-08142-y
13	齐艳丽, 刘桃雪, 于海深, 等. 非洲猪瘟病毒p54蛋白单克隆抗体制备及其抗原表位鉴定[J]. 畜牧兽医学报, 2023, 54 (1): 281- 292.
	QI Y L , LIU T X , YU H S , et al. Preparation of the monoclonal antibody against the African swine fever virus p54 protein and identification of the antigenic epitope[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54 (1): 281- 292.
14	ALONSO C , MISKIN J , HERNAÁEZ B , et al. African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein[J]. J Virol, 2001, 75 (20): 9819- 9827. doi: 10.1128/JVI.75.20.9819-9827.2001
15	矫健, 李建达, 韩先杰, 等. 非洲猪瘟病毒p22蛋白单克隆抗体的制备及鉴定[J]. 山东农业科学, 2023, 55 (10): 140- 145.
	JIAO J , LI J D , HAN X J , et al. Preparation and identification of monoclonal antibody against p22 protein of African swine fever virus[J]. Shandong Agricultural Sciences, 2023, 55 (10): 140- 145.
16	VUONO E A , RAMIREZ-MEDINA E , PRUITT S , et al. Evaluation of the function of the ASFV KP177R gene, encoding for structural protein p22, in the process of virus replication and in swine virulence[J]. Viruses, 2021, 13 (6): 986. doi: 10.3390/v13060986
17	范婷婷. 非洲猪瘟病毒结构蛋白的免疫原性探索[D]. 北京: 中国农业科学院, 2021.
	FAN T T. Exploration of the immunogenicity of structural proteins of African swine fever virus[D]. Beijing: Chinese Academy of Agricultural Sciences, 2021. (in Chinese)
18	XIA N W , WANG H , LIU X L , et al. African swine fever virus structural protein p17 inhibits cell proliferation through ER stress—ROS mediated cell cycle arrest[J]. Viruses, 2020, 13 (1): 21. doi: 10.3390/v13010021
19	LIU H L , WANG A P , YANG W R , et al. Expression of extracellular domain of ASFV CD2v protein in mammalian cells and identification of B cell epitopes[J]. Virus Res, 2023, 323, 199000. doi: 10.1016/j.virusres.2022.199000
20	KARGER A , PÉREZ-NÚÑEZ D , URQUIZA J , et al. An update on African swine fever virology[J]. Viruses, 2019, 11 (9): 864. doi: 10.3390/v11090864
21	张敏. 非洲猪瘟病毒CD2v蛋白影响猪肺泡巨噬细胞功能的研究[D]. 哈尔滨: 东北农业大学, 2022.
	ZHANG M. Effects of African swine fever virus CD2v protein on porcine alveolar macrophages function[D]. Harbin: Northeast Agricultural University, 2022. (in Chinese)
22	田盼盼, 秦晓东, 宋金星, 等. 非洲猪瘟病毒CD2v蛋白的生物信息学分析及多表位疫苗的设计[J]. 中国兽医杂志, 2021, 57 (9): 1- 5.
	TIAN P P , QIN X D , SONG J X , et al. Bioinformatics analysis of African swine fever virus CD2v protein for design of a Multiepitope vaccine[J]. Chinese Journal of Veterinary Medicine, 2021, 57 (9): 1- 5.
23	PÉREZ-NÚÑEZ D , GARCÍA-URDIALES E , MARTÍNEZ-BONET M , et al. CD2v interacts with adaptor protein AP-1 during African swine fever infection[J]. PLoS One, 2015, 10 (4): e0123714. doi: 10.1371/journal.pone.0123714
24	王彩霞, 冯春燕, 肖颖, 等. 基于非洲猪瘟病毒p72蛋白的阻断ELISA检测方法的建立及初步应用[J]. 中国兽医科学, 2021, 51 (11): 1341- 1347.
	WANG C X , FENG C Y , XIAO Y , et al. Establishment and preliminary application of a blocking ELISA based on p72 protein of African swine fever virus[J]. Chinese Veterinary Science, 2021, 51 (11): 1341- 1347.
25	HAKIZIMANA J N , NYABONGO L , NTIRANDEKURA J B , et al. Genetic analysis of African swine fever virus from the 2018 outbreak in south-eastern burundi[J]. Front Vet Sci, 2020, 7, 578474. doi: 10.3389/fvets.2020.578474
26	LIU Q , MA B T , QIAN N C , et al. Structure of the African swine fever virus major capsid protein p72[J]. Cell Res, 2019, 29 (11): 953- 955. doi: 10.1038/s41422-019-0232-x
27	CHEN X N , CHEN X J , LIANG Y F , et al. Interaction network of African swine fever virus structural protein p30 with host proteins[J]. Front Microbiol, 2022, 13, 971888. doi: 10.3389/fmicb.2022.971888
28	WANG N , ZHAO D M , WANG J L , et al. Architecture of African swine fever virus and implications for viral assembly[J]. Science, 2019, 366 (6465): 640- 644. doi: 10.1126/science.aaz1439
29	ZHANG Y , MAO D L , ROSWIT W T , et al. PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection[J]. Nat Immunol, 2015, 16 (12): 1215- 1227. doi: 10.1038/ni.3279
30	IWATA H , GOETTSCH C , SHARMA A , et al. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation[J]. Nat Commun, 2016, 7 (1): 12849. doi: 10.1038/ncomms12849
31	BOLZE A , MAHLAOUI N , BYUN M , et al. Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia[J]. Science, 2013, 340 (6135): 976- 978. doi: 10.1126/science.1234864
32	WU Y H , TAN X D , LIU P , et al. ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways[J]. Exp Cell Res, 2019, 379 (1): 30- 47. doi: 10.1016/j.yexcr.2019.03.022
33	ORIHUELA C J , MAHDAVI J , THORNTON J , et al. Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models[J]. J Clin Invest, 2009, 119 (6): 1638- 1646. doi: 10.1172/JCI36759
34	ZHU Z X , LI W W , ZHANG X L , et al. Foot-and-mouth disease virus capsid protein VP1 interacts with host ribosomal protein SA To maintain activation of the MAPK signal pathway and promote virus replication[J]. J Virol, 2020, 94 (3): e01350- 19.
35	BACKE P H , MESSIAS A C , RAVELLI R B G , et al. X-Ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids[J]. Structure, 2005, 13 (7): 1055- 1067. doi: 10.1016/j.str.2005.04.008
36	BOMSZTYK K , DENISENKO O , OSTROWSKI J . hnRNP K: one protein multiple processes[J]. BioEssays, 2004, 26 (6): 629- 638. doi: 10.1002/bies.20048
37	FORD L P , WRIGHT W E , SHAY J W . A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation[J]. Oncogene, 2002, 21 (4): 580- 583. doi: 10.1038/sj.onc.1205086
38	HERNAEZ B , ESCRIBANO J M , ALONSO C . African swine fever virus protein p30 interaction with heterogeneous nuclear ribonucleoprotein K (hnRNP-K) during infection[J]. FEBS Lett, 2008, 582 (23-24): 3275- 3280. doi: 10.1016/j.febslet.2008.08.031
39	DEJGAARD K , LEFFERS H . Characterisation of the nucleic-acid-binding activity of KH domains different properties of different domains[J]. Eur J Biochem, 1996, 241 (2): 425- 431. doi: 10.1111/j.1432-1033.1996.00425.x
40	ALFONSO P , RIVERA J , HERNÁEZ B , et al. Identification of cellular proteins modified in response to African swine fever virus infection by proteomics[J]. Proteomics, 2004, 4 (7): 2037- 2046. doi: 10.1002/pmic.200300742
41	NAKATSU F , OHNO H . Adaptor protein complexes as the key regulators of protein sorting in the post-golgi network[J]. Cell Struct Funct, 2003, 28 (5): 419- 429. doi: 10.1247/csf.28.419
42	LAGUETTE N , BRÉGNARD C , BENICHOU S , et al. Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins[J]. Mol Aspects Med, 2010, 31 (5): 418- 433. doi: 10.1016/j.mam.2010.05.003
43	MADRID R , JANVIER K , HITCHIN D , et al. Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity[J]. J Biol Chem, 2005, 280 (6): 5032- 5044. doi: 10.1074/jbc.M401202200
44	MORI Y , KOIKE M , MORIISHI E , et al. Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway[J]. Traffic, 2008, 9 (10): 1728- 1742. doi: 10.1111/j.1600-0854.2008.00796.x
45	NETHERTON C L , MCCROSSAN M C , DENYER M , et al. African swine fever virus causes microtubule-dependent dispersal of the trans-golgi network and slows delivery of membrane protein to the PlasmaMembrane[J]. J Virol, 2006, 80 (22): 11385- 11392. doi: 10.1128/JVI.00439-06
46	COSKUN M , SALEM M , PEDERSEN J , et al. Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease[J]. Pharmacol Res, 2013, 76, 1- 8. doi: 10.1016/j.phrs.2013.06.007
47	ZAIM Ö , DOǦANLAR O , BANU DOǦANLAR Z , et al. Novel synthesis naringenin-benzyl piperazine derivatives prevent glioblastoma invasion by inhibiting the hypoxia-induced IL6/JAK2/STAT3 axis and activating caspase-dependent apoptosis[J]. Bioorg Chem, 2022, 129, 106209. doi: 10.1016/j.bioorg.2022.106209
48	LI X M , SUN J , PRINZ R A , et al. Inhibition of porcine epidemic diarrhea virus (PEDV) replication by A77 1726 through targeting JAK and Src tyrosine kinases[J]. Virology, 2020, 551, 75- 83. doi: 10.1016/j.virol.2020.06.009
49	GAO Q , YANG Y L , LUO Y Z , et al. African swine fever virus envelope glycoprotein CD2v interacts with host CSF2RA to regulate the JAK2-STAT3 pathway and inhibit apoptosis to facilitate virus replication[J]. J Virol, 2023, 97 (4): e0188922. doi: 10.1128/jvi.01889-22
50	LIU J , XU XU X N , FENG X Q , et al. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251[J]. J Exp Clin Cancer Res, 2011, 30 (1): 80. doi: 10.1186/1756-9966-30-80
51	FAZI B , COPE M J T V , DOUANGAMATH A , et al. Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1:structural and functional analysis[J]. J Biol Chem, 2002, 277 (7): 5290- 5298. doi: 10.1074/jbc.M109848200
52	GLYVUK N , TSYTSYURA Y , THIEL C , et al. Disturbance of synaptic vesicle recycling resulting from deletion of a mammalian actin-binding protein, mAbp1[J]. Neurophysiology, 2007, 39 (4-5): 341- 342. doi: 10.1007/s11062-007-0051-4
53	FUCINI R V , CHEN J L , SHARMA C , et al. Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1[J]. Mol Biol Cell, 2002, 13 (2): 621- 631. doi: 10.1091/mbc.01-11-0547
54	YAMAZAKI H , TAKAHASHI H , AOKI T , et al. Molecular cloning and dendritic localization of rat SH3P7[J]. Eur J Neurosci, 2001, 14 (6): 998- 1008. doi: 10.1046/j.0953-816x.2001.01727.x
55	ROSENDALE M , VAN T , GRILLO-BOSCH D , et al. Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis[J]. Nat Commun, 2019, 10 (1): 4462. doi: 10.1038/s41467-019-12434-9
56	YAMADA E , BASTIE C C . Disruption of Fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase[J]. PLoS One, 2014, 9 (2): e89604. doi: 10.1371/journal.pone.0089604
57	KAY-JACKSON P C , GOATLEY L C , COX L , et al. The CD2v protein of African swine fever virus interacts with the actin-binding adaptor protein SH3P7[J]. J Gen Virol, 2004, 85 (1): 119- 130. doi: 10.1099/vir.0.19435-0
58	PFISTER K K , SHAH P R , HUMMERICH H , et al. Genetic analysis of the cytoplasmic dynein subunit families[J]. PLoS Genet, 2006, 2 (1): e1. doi: 10.1371/journal.pgen.0020001
59	MALLIK R , PETROV D , LEX S A , et al. Building complexity: an in vitro study of cytoplasmic dynein with in vivo implications[J]. Curr Biol, 2005, 15 (23): 2075- 2085. doi: 10.1016/j.cub.2005.10.039
60	ZAVALA-VARGAS D I , VISOSO-CARBAJAL G , CEDILLO-BARRÓN L , et al. Interaction of the Zika virus with the cytoplasmic dynein-1[J]. Virol J, 2023, 20 (1): 43. doi: 10.1186/s12985-023-01992-6
61	HERNÁEZ B , DIÍAZ-GIL G , GARCIÍA-GALLO M , et al. The African swine fever virus dynein-binding protein p54 induces infected cell apoptosis[J]. FEBS Lett, 2004, 569 (1-3): 224- 228. doi: 10.1016/j.febslet.2004.06.001
62	ZHU X J , FAN B C , ZHOU J M , et al. A high-throughput method to analyze the interaction proteins with p22 protein of African swine fever virus in vitro[J]. Front Vet Sci, 2021, 8, 719859. doi: 10.3389/fvets.2021.719859
63	FISH I , BOISSINOT S . Functional evolution of the OAS1 viral sensor: insights from old world primates[J]. Infect Genet Evol, 2016, 44, 341- 350. doi: 10.1016/j.meegid.2016.07.005
64	HUANG Y Z , ZHENG Y X , ZHOU Y , et al. OAS1, OAS2, and OAS3 contribute to epidermal keratinocyte proliferation by regulating cell cycle and augmenting IFN-1-induced jak1-signal transducer and activator of transcription 1 phosphorylation in psoriasis[J]. J Invest Dermatol, 2022, 142 (10): 2635- 2645. doi: 10.1016/j.jid.2022.02.018
65	SUN H L , WU M L , ZHANG Z H , et al. OAS1 suppresses African swine fever virus replication by recruiting TRIM21 to degrade viral major capsid protein[J]. J Virol, 2023, 97 (10): e0121723. doi: 10.1128/jvi.01217-23
66	GAO L , LIU R , YANG F C , et al. Duck enteritis virus inhibits the cGAS-STING DNA-sensing pathway to evade the innate immune response[J]. J Virol, 2022, 96 (24): e0157822. doi: 10.1128/jvi.01578-22
67	ZHENG W L , XIA N W , ZHANG J J , et al. African swine fever virus structural protein p17 inhibits cGAS-STING signaling pathway through interacting with STING[J]. Front Immunol, 2022, 13, 941579. doi: 10.3389/fimmu.2022.941579
68	HU B L , ZHONG G F , DING S X , et al. African swine fever virus protein p17 promotes mitophagy by facilitating the interaction of SQSTM1 with TOMM70[J]. Virulence, 2023, 14 (1): 2232707. doi: 10.1080/21505594.2023.2232707
69	LIU H S , ZHU Z X , FENG T , et al. African swine fever virus E120R protein inhibits interferon beta production by interacting with IRF3 to block its activation[J]. J Virol, 2021, 95 (18): e0082421. doi: 10.1128/JVI.00824-21
70	崔帅, 王洋, 郭晓宇, 等. 利用酵母双杂交技术筛选和鉴定非洲猪瘟病毒E120R蛋白的互作宿主蛋白[J]. 中国畜牧兽医, 2022, 49 (11): 4139- 4149.
	CUI S , WANG Y , GUO X Y , et al. Screening and identification of the host proteins interacting with African swine fever virus E120R protein using yeast two-hybrid[J]. China Animal Husbandry & Veterinary Medicine, 2022, 49 (11): 4139- 4149.
71	JOUVENET N , MONAGHAN P , WAY M , et al. Transport of African swine fever virus from assembly sites to the plasma membrane is dependent on microtubules and conventional kinesin[J]. J Virol, 2004, 78 (15): 7990- 8001. doi: 10.1128/JVI.78.15.7990-8001.2004
72	SUN M W , YU S X , GE H L , et al. The A137R protein of African swine fever virus inhibits type Ⅰ interferon production via the autophagy-mediated lysosomal degradation of TBK1[J]. J Virol, 2022, 96 (9): e0195721. doi: 10.1128/jvi.01957-21

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Research Progress on the Interactions of African Swine Fever Virus Structural Proteins with Host Proteins

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