新城疫病毒M蛋白与宿主蛋白相互作用的研究进展

doi:10.11843/j.issn.0366-6964.2022.01.004

Abstract

Abstract: Newcastle disease virus (NDV) is a kind of single-stranded negative-sense non-segmented RNA virus, which contains the genome size of about 15.2 kb in length that encodes six structural proteins and two non-structural proteins. Since the NDV genome is smaller, it cannot encode all the proteins needed for viral replication, thus host proteins must be employed to complete the life cycle of NDV. The NDV M protein is a non-glycosylated membrane-associated protein, which plays essential roles in inhibiting host cell gene transcription, regulating the replication and transcription of the NDV genome, and promoting the assembly and budding of progeny virions. At present, great research progresses have been made in the relationship between M protein and NDV virulence and replication, and the formation and utilization of M protein-based virus-like particles. However, there has little progress about the roles of NDV M protein interaction with host proteins in regulating NDV replication. Due to the crucial roles of M protein in NDV replication, this summary mainly reviews the structural characteristics and intracellular localization characteristics of M protein, and also the functional study on the interactions between M protein and host proteins, which will provide theoretical references for better understanding and studying the role of M protein in the replication and pathogenicity of NDV.

Key words: Newcastle disease virus, M protein, host protein, protein-protein interaction, virus replication

CLC Number:

DUAN Zhiqiang, XIE Lingling, CHEN Jiaqi, TANG Hong, WANG Yanbi, ZHAO Caiqin, ZHAO Jiafu. Research Progress on the Interactions of Newcastle Disease Virus M Protein with Host Proteins[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(1): 32-42.

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Research Progress on the Interactions of Newcastle Disease Virus M Protein with Host Proteins

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