多杀性巴氏杆菌的摄铁机制研究进展

doi:10.11843/j.issn.0366-6964.2024.11.007

Abstract

Abstract:

Pasteurella multocida (P. multocida) can infect a wide range of animals, causing hemorrhagic septicemia or infectious pneumonia. Iron is an essential nutrient for growth, colonization, and proliferation of P. multocida during infection of the host, and competition for iron ions in the host is a critical link in the pathogenesis of this pathogen. In recent years, a series of significant research advances have progressed in the iron uptake system of P. multocida, as well as its occurrence and regulatory mechanisms. The mechanisms of iron uptake by transferrin, heme receptors and siderophore, and the mechanism of expression and regulation of the P. multocida iron uptake system are all described in this paper. Aiming to provide systematic theoretical knowledge for the study of the molecular pathogenesis of the P. multocida iron uptake system and to spark new ideas for the investigation and development of molecular target drugs and subunit vaccines of P. multocida.

Key words: Pasteurella multocida, iron uptake mechanism, siderophore, ExbB-ExbD-TonB, Fur

CLC Number:

Xiangxiang SHEN, Lijun GUAN, Junfeng ZHANG, Yun XUE, Lifang SI, Zhanqin ZHAO. Research Progress on Iron Uptake Mechanism of Pasteurella multocida[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(11): 4852-4862.

Figures/Tables 4

References 97

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Research Progress on Iron Uptake Mechanism of Pasteurella multocida

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