牦牛基因组拷贝数变异研究进展

doi:10.11843/j.issn.0366-6964.2024.03.008

Abstract

Abstract: Copy number variation (CNV) is an important component of genomic structural variation (SV). Compared with SNP (single nucleotide polymorphism), CNV shows more complex genetic variation, which is of great significance in the study of genetic mechanism of important economic traits, disease inducements, and evolution of species. As a unique bovine species in the Qinghai-Tibet Plateau (QTP), with the rapid development of high-throughput sequencing technology and the continuous upgrading of yak reference genomes, the study of CNV at the whole genome level in yak has made important progress in recent years. Here, on the basis of describing the formation principle, function mechanism and detection method of genomic CNV, the current research status of genomic CNV in yak in recent 10 years were reviewed, and some existing problems and shortcomings were analyzed and explored. Furthermore, the future development and application trends were prospected, in order to provide reference for further yak genome research and accelerating molecular breeding process of yak genetic resources.

Key words: Bos grunniens, genome, copy number variation (CNV)

CLC Number:

S823.85

XU Donghui, XU Yuhui, LI Ruizhe, CHENG Haijian, MA Zhijie. Research Progress of Genome Copy Number Variations in Yak[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(3): 933-943.

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Research Progress of Genome Copy Number Variations in Yak

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